Dopamine D 3 Receptors Modulate the Ability of Win-Paired Cues to Increase Risky Choice in a Rat Gambling Task
Open accessAbstract
Similar to other addiction disorders, the cues inherent in many gambling procedures are thought to play an important role in mediating their addictive nature. Animal models of gambling-related behavior, while capturing dimensions of economic decision making, have yet to address the impact that these salient cues may have in promoting maladaptive choice. Here, we determined whether adding win-associated audiovisual cues to a rat gambling task (rGT) would influence decision making. Thirty-two male Long–Evans rats were tested on either the cued or uncued rGT. In these tasks, animals chose between four options associated with different magnitudes and frequencies of reward and punishing time-out periods. As in the Iowa Gambling Task, favoring options associated with smaller per-trial rewards but smaller losses and avoiding the tempting “high-risk, high-reward” decks maximized profits. Although the reinforcement contingencies were identical in both task versions, rats' choice of the disadvantageous risky options was significantly greater on the cued task. Furthermore, a D 3 receptor agonist increased choice of the disadvantageous options, whereas a D 3 antagonist had the opposite effects, only on the cued task. These findings are consistent with the reported role of D 3 receptors in mediating the facilitatory effects of cues in addiction. Collectively, these results indicate that the cued rGT is a valuable model with which to study the mechanism by which salient cues can invigorate maladaptive decision making, an important and understudied component of both gambling and substance use disorders. SIGNIFICANCE STATEMENT We used a rodent analog of the Iowa Gambling Task to determine whether the addition of audiovisual cues would affect choice preferences. Adding reward-concurrent cues significantly increased risky choice. This is the first clear demonstration that reward-paired cues can bias cost/benefit decision making against a subject's best interests in a manner concordant with elevated addiction susceptibility. Choice on the cued task was uniquely sensitive to modulation by D 3 receptor ligands, yet these drugs did not alter decision making on the uncued task. The relatively unprecedented sensitivity of choice on the cued task to D 3 -receptor-mediated neurotransmission data suggest that similar neurobiological processes underlie the ability of cues to both bias animals toward risky options and facilitate drug addiction.
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The introduction of salient cues to winning trials in the cued rodent gambling task results in riskier and more disadvantageous choice behavior than the uncued task.
“Similarly, the introduction of salient cues to winning trials, to what is termed the cued rGT, results in riskier and more disadvantageous choice behavior than when exposed to the uncued task (Barrus & Winstanley, 2016).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Barrus & Winstanley, 2016
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“Similarly, the introduction of salient cues to winning trials, to what is termed the cued rGT, results in riskier and more disadvantageous choice behavior than when exposed to the uncued task (Barrus & Winstanley, 2016).”
- Authors
- Barrus, M. M., & Winstanley, C. A.
- Affiliations
- University of British Columbia (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2016-01-20
- Volume
- 36
- Issue
- 3
- Pages
- 785-794
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6602008
- OpenAlex
- W2335309699
- Cited by
- 93
- References
- 58
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 8 · 2016: 11 · 2015: 1
- FWCI
- 17.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Michael Smith Health Research BC
- Canadian Institutes of Health Research
- Topics
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- dopamine D3 receptor, gambling, decision making under risk, audiovisual cues, cue reactivity, economic decision-making, D3 receptor agonists, D3 receptor antagonists, addiction, cost-benefit decision making, Iowa Gambling Task
- MeSH terms
- Animals, Choice Behavior, Cues, Gambling, Male, Risk-Taking, Dopamine Agonists, Dopamine Antagonists, Rats, Long-Evans, Receptors, Dopamine D3, Rats
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