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Association of Dopamine Agonist Use With Impulse Control Disorders in Parkinson Disease
Open accessAbstract
OBJECTIVE: To determine the frequency and correlates of impulse control disorders (ICDs) in Parkinson disease (PD). DESIGN: An unstructured screening interview for ICDs (compulsive gambling, buying, and sexual behavior) followed by a telephone-administered structured interview for screen-positive patients. SETTING: Two university-affiliated movement disorders centers. PARTICIPANTS: A convenience sample of 272 patients with idiopathic PD who were screened for psychiatric complications. MAIN OUTCOME MEASURES: Presence of compulsive gambling, buying, or sexual behavior as assessed by the Minnesota Impulsive Disorders Interview. RESULTS: Eighteen patients (6.6%) with PD met criteria for an ICD at some point during the course of PD, including 11 (4.0%) with an active ICD. Compulsive gambling and compulsive sexual behavior were equally common. In a multivariate model, treatment with a dopamine agonist (P = .01) and a history of ICD symptoms prior to PD onset (P = .02) predicted current ICD. There were no differences between the dopamine agonists in their association with ICDs (P = .21), and daily doses of dopamine agonists were higher in patients with an ICD than in dopamine agonist-treated patients without an ICD (P < .001). CONCLUSIONS: Patients with PD treated with a dopamine agonist should be made aware of the risk of developing an ICD and monitored clinically. Because dopamine agonists are increasingly being used for other indications, future research should assess the dopamine agonist-associated risk for ICDs in other populations.
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“impulse-control disorder (ICD) development in PD patients has been associated with dopamine agonist pharmacotherapy (Weintraub et al., 2006”
From Remote delivery of psychological interventions for Parkinson's disease. (2018) · cites this paper as Weintraub et al., 2006
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Self-citationValidation of the questionnaire for impulsive‐compulsive disorders in Parkinson's disease
Weintraub, D., Hoops, S., Shea, J. A., Lyons, K. E., Pahwa, R., Driver‐Dunckley, E. D., Adler, C. H., Potenza, M. N., Miyasaki, J., Siderowf, A. D., et al. (2009) · Movement Disorders · doi:10.1002/mds.22571 · Cited by 528
“The Minnesota Impulsive Disorders Interview (MIDI),(22) which includes sections for compulsive gambling, sexual behavior, and buying, has been used in PD.(4,17) However, the MIDI does not cover compulsive eating or other compulsive behaviors, and thresholding of scores to identify cases has varied across studies.”
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“7%).(32,33) The association with any specific dopamine agonist is unclear because of the variable prescribing habits of clinics and different methods of measuring prevalence rates.”
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Brewer, J. A., & Potenza, M. N. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.043 · Cited by 540
“A recent study of 272 PD patients who were screened and assessed for ICDs found similarly strong associations across DA agonists with PG and other ICDs [61].”
Self-citationThe neurobiology of pathological gambling and drug addiction: an overview and new findings
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Cognitive-behavioral therapy for psychogenic nonepileptic seizures
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Self-citationParkinson's disease: The quintessential neuropsychiatric disorder
Weintraub, D. A., & Burn, D. J. (2011) · Movement Disorders · doi:10.1002/mds.23664 · Cited by 422
“As patients may not report such behaviors to a treating physician, either because of embarrassment and not suspecting an association with PD treatment or ambivalence regarding ceasing the behavior or treatment, ICDs remain generally underrecognized in clinical practice.(119) In a recent large multisite observational s…”
BackgroundSelf-citationMedication-Related Impulse Control and Repetitive Behaviors in Parkinson Disease
Voon, V., & Fox, S. H. (2007) · Archives of Neurology · doi:10.1001/archneur.64.8.1089 · Cited by 397
“In a separate study, pathological gambling, hypersexuality, and compulsive shopping assessed as a group were associated with a higher LED.(2) The relationship between medications and punding is less clear.”
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Weintraub, D. A., Mamikonyan, E., Papay, K., Shea, J. A., Xie, S. X., & Siderowf, A. D. (2011) · Movement Disorders · doi:10.1002/mds.24023 · Cited by 393
“Hence, there is evidence that ICDs are underrecognized in routine clinical PD care.(2) There are limited options in terms of assessment instruments for ICDs and related disorders in PD.”
BackgroundSelf-citationZeeb, F. D., Robbins, T. W., & Winstanley, C. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.62 · Cited by 403
“Such an impairment in temporal judgment would have increased the perceived duration of the punishing timeouts, thereby biasing preference toward P1. However, amphetamine has been shown to increase choice of larger, but more delayed, rewards in delay-discounting paradigms (for example, van Gaalen et al, 2006b; Wade et…”
BackgroundVoon, V., Fernagut, P., Wickens, J. R., Baunez, C., Rodríguez-Oroz, M. C., Pavon, N., Juncos, J. L., Obeso, J. A., & Bézard, E. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70287-x · Cited by 365
Dopamine Agonist Withdrawal Syndrome in Parkinson Disease
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“62 MMSE score, median (IQR) 30 (28-30) 29 (29-30) .”
Personality, Addiction, Dopamine: Insights from Parkinson's Disease
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Clinical spectrum of impulse control disorders in Parkinson’s disease
Weintraub, D., David, A. S., Evans, A. H., Grant, J. E., & Stacy, M. (2015) · Movement Disorders · doi:10.1002/mds.26016 · Cited by 311
“There is evidence that ICD behaviors in PD patients continue to be under-recognized and undermanaged in clinical practicel.(8,30,65) Ongoing under-recognition could be, in part, a result of the fact that routine screening is not common; in addition, patients may not report symptoms either because of embarrassment, lim…”
BackgroundSelf-citationReward Signals, Attempted Suicide, and Impulsivity in Late-Life Depression
Dombrovski, A. Y., Szanto, K., Clark, L., Reynolds, C. F., & Siegle, G. J. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.75 · Cited by 289
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“Here, we focused on compulsive disorders triggered in Parkinson’s disease (PD) by dopamine agonists (DA) (Dagher and Robbins, 2009; Voon et al., 2007; Weintraub et al., 2006).”
Decision-making during gambling: an integration of cognitive and psychobiological approaches
Clark, L. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0147 · Cited by 322
“The emergence of these impulse control disorders appears to be linked to treatment with dopamine agonist medications (Weintraub et al. 2006), and in particular, to two drugs, pramipexole and ropinirole, that have a relatively high affinity for the dopamine D3 receptor (Dodd et al. 2005).”
BackgroundImpulse Control and Related Disorders in Parkinson's Disease
Weintraub, D. A., & Claassen, D. O. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.04.006 · Cited by 284
Self-citationRuiz, P., Martínez‐Castrillo, J. C., Cánovas, A. A., Bárcenas, A. H., Vela, L., Alonso, P. S., Mata, M. J. D., Gonzalez, N. O., & Mahíllo, I. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-306787 · Cited by 258
Longitudinal analysis of impulse control disorders in Parkinson disease
Corvol, J.-C., Artaud, F., Cormier-Dequaire, F., Rascol, O., Durif, F., Derkinderen, P., Marques, A.-R., Bourdain, F., Brandel, J.-P., Pico, F., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005816 · Cited by 253
Pathological gambling after bilateral subthalamic nucleus stimulation in Parkinson disease
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Rogers, R. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.165 · Cited by 262
“…administration of dopamine therapiesFincluding, for example, drugs that on act upon the D2 family of receptorsFappears to induce problems with gambling and other compulsive behaviors in a minority of Parkinsonian patients (Dodd et al, 2005; Voon et al, 2006a, b; Weintraub et al, 2006) (see below).”
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Long‐term follow‐up of impulse control disorders in Parkinson's disease
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Self-citationImpulsive and compulsive behaviors in Parkinson's disease
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“In one small prospective study, the frequency of active compulsive buying has been estimated at 0.4% using the MIDI.22 Another small study using self-rated 19-item yes/no buying questionnaire20 estimated a prevalence for compulsive buying of 2.4%.21 However, a prevalence estimate of 5.7% in a large study of more than…”
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Pizzagalli, D. A., Evins, A. E., Schetter, E. C., Frank, M. J., Pajtas, P. E., Santesso, D. L., & Culhane, M. (2008) · Psychopharmacology · doi:10.1007/s00213-007-0957-y · Cited by 219
“, compulsive gambling), failing to inhibit behaviors with negative consequences (Weintraub et al. 2006).”
Gallagher, D. A., O’Sullivan, S. S., Evans, A. H., Lees, A. J., & Schrag, A. E. (2007) · Movement Disorders · doi:10.1002/mds.21611 · Cited by 224
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“…recognition of the incidence of ICD, probably related to the increased use of dopamine agonists (Grosset et al., 2006; Lu et al., 2006; Voon et al., 2006; Weintraub et al., 2006; Evans and Butzkueven, 2007; McKeon et al., 2007; Quickfall and Suchowersky, 2007; Tippmann-Peikert et al., 2007).”
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Voon, V., Reynolds, B. A., Brezing, C., Galléa, C., Skaljic, M., Ekanayake, V., Fernandez, H. H., Potenza, M. N., Dolan, R. J., & Hallett, M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1697-y · Cited by 222
“In this study, we focused on ICDs associated with DA use in Parkinson’s disease (PD; Voon et al. 2006; Weintraub et al. 2006).”
MethodSelf-citationCognitive enhancement by drugs in health and disease
Husain, M., & Mehta, M. A. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.002 · Cited by 241
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“These treatments induce a stronger preference for immediate over larger delayed rewards (Housden et al. 2010 ; Voon et al. 2010) and trigger substance abuse, gambling, hypomania and inappropriate sexual behaviors (Weintraub et al. 2006).”
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Predictors of impulsivity and reward seeking behavior with dopamine agonists
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“Some risk factors for these pathologic behaviors have been reported [11,21–23].”
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Antonini, A., TOLOSA, E. S., Mizuno, Y., Yamamoto, M., & Poewe, W. H. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70225-x · Cited by 194
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“Impulse control disorders including hypersexuality and compulsive sexual behaviour are a significant source of morbidity for patients with Parkinson's disease receiving dopamine replacement therapy (Weintraub et al., 2006; Evans et al., 2009; Voon et al., 2009).”
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Self-citationDopamine and impulse control disorders in Parkinson's disease
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Self-citationSubthalamic deep brain stimulation and impulse control in Parkinson’s disease
Hälbig, T. D., Tse, W., Frisina, P. G., Baker, B. R., Hollander, E., Shapiro, H., Tagliati, M., Koller, W. C., & Olanow, C. W. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02509.x · Cited by 187
“Impulse control disorders (ICDs) such as pathologic gambling, compulsive shopping, and hypersexuality as well as other compulsive repetitive behaviors such as punding are increasingly being recognized in patients with Parkinson s disease (PD) [1], and have been linked to the use of dopaminergic medications and in part…”
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“As in the previous reports [7,13,25,26], patients who were younger at PD onset had a higher risk of developing both ICDs and PUND in our study.”
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“These include impaired working memory, planning, attention (Aarsland et al., 2011), decreased speed of processing (Uc et al., 2005), impulse control disorders (ICDs) (Pontone et al., 2006) associated with dopamine agonists (Weintraub et al., 2006), and disordered thought (Factor et al., 2003).”
Serotonin and Parkinson's disease: On movement, mood, and madness
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The nonmotor symptoms of Parkinson's disease—An overview
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“One recent study showed that only one quarter of PD patients with active ICDs had been identified clinically as having the problem.(75)”
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“Table 1 shows the relevant demographic information for the two groups, including the average DBS stimulation parameters and levodopa equivalents (Weintraub et al., 2006) for patients with Parkinson’s disease at the time of testing.”
BackgroundProspective cohort study of impulse control disorders in Parkinson's disease
Bastiaens, J., Dorfman, B. J., Christos, P. J., & Nirenberg, M. J. (2013) · Movement Disorders · doi:10.1002/mds.25291 · Cited by 167
“Moreover, although the primary treatment for ICDs is to taper or discontinue DAA therapy, not all patients are able to tolerate this because of motor worsening or because of dopamine agonist withdrawal syndrome (DAWS), a severe nonmotor drug withdrawal syndrome that mimics that of cocaine and other psychostimulants.(1…”
BackgroundMethodNeurobiology of cue-reactivity, craving, and inhibitory control in non-substance addictive behaviors
Antons, S., Brand, M., & Potenza, M. N. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116952 · Cited by 187
Self-citationMedication-related impulse control and repetitive behaviors in Parkinson??s disease
Voon, V., Potenza, M. N., & Thomsen, T. R. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32826fbc8f · Cited by 162
Self-citationImpulsivity and compulsivity in drug‐naïve patients with Parkinson's disease
Antonini, A., Siri, C., Santangelo, G., Cilia, R., Poletti, M., Canesi, M., Caporali, A., Mancini, F., Pezzoli, G., Ceravolo, R., et al. (2011) · Movement Disorders · doi:10.1002/mds.23501 · Cited by 162
“ICDs were defined positive in the presence of problem/pathological SOGS (cut-off score >3) or answering affirmatively at the MIDI scale to one gateway question plus an affirmative answer to one or more of the remaining questions.(3,5) The BIS-11 is a commonly used scale to assess three different dimensions of impulsiv…”
BackgroundMethodInfluentialThe Neuropsychiatry of Parkinson Disease: A Perfect Storm
Weintraub, D. A., & Mamikonyan, E. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.03.002 · Cited by 172
Self-citationParkinson's disease treatment may cause impulse-control disorder via dopamine D3 receptors
Seeman, P. M. (2015) · Synapse · doi:10.1002/syn.21805 · Cited by 160
“…shopping, pathological gambling, hypersexuality, punding, compulsive medication use, and compulsive or binge eating (Bastiens et al., 2013; Bostwick et al., 2009; Joutsa et al., 2012; Molina et al., 2000; Ondo and Lai, 2008; Poletti et al., 2013; Voon and Fox, 2007; Weintraub et al., 2006, 2010).”
BackgroundDopamine Agonists and Impulse Control Disorders: A Complex Association
Grall‐Bronnec, M., Victorri‐Vigneau, C., Donnio, Y., Leboucher, J., Rousselet, M., Thiabaud, E., Zreika, N., Derkinderen, P., & Challet‐Bouju, G. (2017) · Drug Safety · doi:10.1007/s40264-017-0590-6 · Cited by 159
“A study assessing PD patients treated with low dosages of DRT did not find any significant association between drug-related factors and ICDs after multivariate analysis [86].”
BackgroundWeintraub, D. A., Sohr, M., Potenza, M. N., Siderowf, A. D., Stacy, M. A., Voon, V., Whetteckey, J., Wunderlich, G. R., & Lang, A. E. (2010) · Annals of Neurology · doi:10.1002/ana.22164 · Cited by 157
“Regarding preliminary evidence for the relationship between amantadine use and ICDs in PD, in a previous study amantadine treatment was associated with the presence of an ICD on univariate analysis, but not in a multivariable model.(19) However, the sample size in that study was nearly 10-fold lower than in this study…”
ResultSelf-citationAssociation of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease
Lee, J., Lee, E. K., Park, S. S., Lim, J., Kim, H. J., Kim, J. S., & Jeon, B. S. (2009) · Movement Disorders · doi:10.1002/mds.22678 · Cited by 155
“The similar threshold has been used in other study.(6) In the interview, current symptoms of ICRB, with their onset during the course of PD, were considered to be positive.”
MethodOlanzapine in the Treatment of Pathological Gambling
McElroy, S. L., Nelson, E. B., Welge, J. A., Kaehler, L. A., & Keck, P. E. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0314 · Cited by 157
“In addition, pathological gambling has been described in patients with Parkinson’s disease receiving dopamine agonists.(28,29) We therefore conducted a single-center, randomized, parallel-group, placebo-controlled, flexible-dose study to assess the efficacy and safety of olanzapine during a 12week course of treatment…”
BackgroundICARUS study: prevalence and clinical features of impulse control disorders in Parkinson’s disease
Antonini, A., Barone, P., Bonuccelli, U., Annoni, K., Asgharnejad, M., Stanzione, P., Avesani, M., & Palandin, F. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-315277 · Cited by 156
“Based on the literature, 9 it was calculated that an expected ICD frequency of 6.6%, with an accepted interval limit of 4.9% (corresponding to 1.7% precision) and a 95% confidence interval (CI) required a sample size of 818 patients; assuming a 18% drop-out rate, 1000 patients were to be recruited.”
BackgroundInfluentialDopamine Agonist Increases Risk Taking but Blunts Reward-Related Brain Activity
Riba, J., Krämer, U. M., Heldmann, M., Richter, S., & Münte, T. F. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002479 · Cited by 158
“Various impulse control disorders characterized by exaggerated activities with high hedonic value have been described for Parkinson patients after treatment with dopaminergic agents [3,12].”
BackgroundDecreased ventral striatal activity with impulse control disorders in Parkinson's disease
Rao, H., Mamikonyan, E., Detre, J. A., Siderowf, A. D., Stern, M. B., Potenza, M. N., & Weintraub, D. A. (2010) · Movement Disorders · doi:10.1002/mds.23147 · Cited by 148
Self-citationThe relationship between impulsivity and impulse control disorders in Parkinson's disease
Isaias, I. U., Siri, C., Cilia, R., Gaspari, D. D., Pezzoli, G., & Antonini, A. (2007) · Movement Disorders · doi:10.1002/mds.21872 · Cited by 147
“001 Education (yr) 11 (5) 12 (5) 5–17 10 (5) 5–17 0.”
Cognitive impairment in Parkinson's disease and dementia with Lewy bodies
Aarsland, D. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.09.034 · Cited by 145
Decision-making with explicit and stable rules in mild Alzheimer's disease
Delazer, M., Sinz, H., Zamarian, L., & Benke, T. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.01.006 · Cited by 143
Awareness and current knowledge of Parkinson’s disease: a neurodegenerative disorder
Khan, A. U., Akram, M., Daniyal, M., & Zainab, R. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1486837 · Cited by 151
Bancos, I., Nannenga, M. R., Bostwick, J. M., Silber, M. H., Erickson, D. Z., & Nippoldt, T. B. (2013) · Clinical Endocrinology · doi:10.1111/cen.12375 · Cited by 140
Frucht, S. J. (2004) · The Neurologist · doi:10.1097/01.nrl.0000131146.08278.a5 · Cited by 139
Targeting impulsivity in Parkinson’s disease using atomoxetine
Kehagia, A. A., Housden, C. R., Regenthal, R., Barker, R. A., Müller, U., Rowe, J. B., Sahakian, B. J., & Robbins, T. W. (2014) · Brain · doi:10.1093/brain/awu117 · Cited by 150
“…conditions treated with dopamine agonists, such as restless leg syndrome (Cornelius et al., 2010); in Parkinson’s disease, these agents increase the risk of impulse control disorder expression (Weintraub et al., 2006) but they do not unequivocally cause it (Evans et al., 2005; Voon et al., 2007).”
BackgroundFunctional Abnormalities Underlying Pathological Gambling in Parkinson Disease
Cilia, R., Siri, C., Marotta, G., Isaias, I. U., Gaspari, D. D., Canesi, M., Pezzoli, G., & Antonini, A. (2008) · Archives of Neurology · doi:10.1001/archneur.65.12.1604 · Cited by 139
Broen, M. P. G., Duits, A., Visser-Vandewalle, V. E. R. M., Temel, Y., & Winogrodzka, A. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.02.013 · Cited by 136
“Especially dopamine agonists have been implicated in the development of impulse control and related disorders [12,30,31].”
BackgroundPathological Gambling and Substance Use Disorders
Wareham, J. D., & Potenza, M. N. (2010) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952991003721118 · Cited by 135
Self-citationMultiple Modes of Impulsivity in Parkinson's Disease
Nombela, C., Rittman, T., Robbins, T. W., & Rowe, J. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085747 · Cited by 142
“[22] # ++ Lee et al.”
BackgroundÉvaluation des troubles comportementaux hyper- et hypodopaminergiques dans la maladie de Parkinson
Ardouin, C., Chéreau, I., Llorca, P., Lhommée, E., Durif, F., Pollak, P., & Krack, P. (2009) · Revue Neurologique · doi:10.1016/j.neurol.2009.06.003 · Cited by 134
Vela, L., Martínez‐Castrillo, J. C., Ruiz, P., Gasca‐Salas, C., Macías, Y. M., Pérez‐Fernández, E., Ybot-Gorrin, I., Valdés, E. L., Kurtis, M. M., Rodriguez, I. J. P., et al. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.07.003 · Cited by 132
“6% using theMinnesota Impulsive Disorders Interview (MIDI) [20].”
InfluentialA systematic review of impulse control disorders in Parkinson’s disease.
Callesen, M. B., Scheel-Krüger, J., Kringelbach, M. L., & Møller, A. (2013) · Journal of Parkinson s Disease · doi:10.3233/jpd-120165 · Cited by 130
“( 20 06 )[ 90 ] 27 2 11 (1 :1 0) PD I: PD I: 92 6 (5 35 ) PD I: 60 (9 ) PD I: 48”
Voon, V., Schoerling, A., Wenzel, S., Ekanayake, V., Reiff, J., Trenkwalder, C., & Sixel‐Döring, F. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-117 · Cited by 128
“DAs are particularly associated with pathological gambling, compulsive shopping, hypersexuality and binge eating [6-10].”
BackgroundMethodDopamine release in ventral striatum of pathological gamblers losing money
Linnet, J., Peterson, E., Doudet, D. J., Gjedde, A., & Møller, A. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01591.x · Cited by 127
Psychiatric Manifestation in Patients with Parkinson's Disease
Han, J. W., Ahn, Y. D., Kim, W.-S., Shin, C. M., Jeong, S. J., Song, Y. S., Bae, Y. J., & Kim, J.-M. (2018) · Journal of Korean Medical Science · doi:10.3346/jkms.2018.33.e300 · Cited by 127
Ceravolo, R., Frosini, D., Rossi, C. A., & Bonuccelli, U. (2009) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(09)70847-8 · Cited by 124
“Other risk factors have been described in relation to PD features such as longer duration of PD [13] as well as early disease onset [12].”
BackgroundMethodSuicidal and death ideation in Parkinson's disease
Nazem, S., Siderowf, A. D., Duda, J. E., Brown, G. K., Have, T. T., Stern, M. B., & Weintraub, D. A. (2008) · Movement Disorders · doi:10.1002/mds.22130 · Cited by 120
“As part of the screening process, patients provided the following information during a semi-structured clinical interview: age, sex, race, marital status, years of education, duration of PD, history of deep brain stimulation (DBS) surgery, current ‘‘heavy’’ alcohol use (i.e., ‡14 drinks per week39), and history of any…”
BackgroundSelf-citationNonmotor Symptoms in Parkinson’s Disease in 2012: Relevant Clinical Aspects
Bonnet, A. M., Jutras, M., Czernecki, V., Corvol, J., & Vidailhet, M. (2012) · Parkinson s Disease · doi:10.1155/2012/198316 · Cited by 119
“Apathy consists in a loss of motivation, which appears in emotional, intellectual domains and in the behavior.”
Vitale, C., Santangelo, G., Trojano, L., Verde, F., Rocco, M., Grossi, D., & Barone, P. (2011) · Movement Disorders · doi:10.1002/mds.23567 · Cited by 118
“6% for gambling, HS, and compulsive shopping in PD patients.(4) Pathological gambling is the most extensively studied ICD in PD.”
BackgroundReward networks in the brain as captured by connectivity measures
Càmara, E. (2009) · Frontiers in Neuroscience · doi:10.3389/neuro.01.034.2009 · Cited by 120
“Moreover, this network can be distorted by dopamine receptor agonists such as pramipexole1, which is widely prescribed to treat Parkinson’s disease but has been reported to cause pathological gambling as well as other impulse control disorders (Dodd et al., 2005; Weintraub et al., 2006).”
Disordered Gambling: Etiology, Trajectory, and Clinical Considerations
Shaffer, H. J., & Martin, R. J. (2011) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-040510-143928 · Cited by 124
Management of sexual dysfunction in Parkinson’s disease
Bronner, G., & Vodušek, D. B. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611411504 · Cited by 117
“Discontinuation of the use of the dopamine agonist was consistently effective in treating HS [Cannas et al. 2007; Weintraub et al. 2006; Voon et al. 2006; Dodd et al. 2005; Klos et al. 2005].”
BackgroundInfluentialLong-term use of pramipexole in the management of restless legs syndrome
Lipford, M. C., & Silber, M. H. (2012) · Sleep Medicine · doi:10.1016/j.sleep.2012.08.004 · Cited by 113
“Impulse control disorders (ICDs) were defined as symptoms of pathologic gambling, hypersexuality, compulsive shopping or compulsive eating attributed to pramipexole therapy [16,17].”
BackgroundInternational validation of a behavioral scale in Parkinson's disease without dementia
Rieu, I., Martínez‐Martín, P., Pereira, B., de Chazeron, I., Metman, L. V., Jahanshahi, M., Ardouin, C., Chéreau, I., Brefel‐Courbon, C., Ory‐Magne, F., et al. (2015) · Movement Disorders · doi:10.1002/mds.26223 · Cited by 112
“Studies particularly highlighted a link between impulse control disorders, dopamine dysregulation syndrome, dopamine agonists, and levodopa.(9,13,21,22) Apathy, depression, and anxiety can be observed at all stages of the disease but are predominant at its onset or when it is undertreated.”
BackgroundBaarendse, P. J. J., Winstanley, C. A., & Vanderschuren, L. J. M. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2857-z · Cited by 111
“For instance, DA agonist therapy has been associated with impairments in decision making in patients with Parkinson ’ s disease and restless leg syndrome (Gallagher et al. 2007; Seedat et al. 2000; Weintraub et al. 2006).”
Impulse Control and Related Disorders in Parkinson’s Disease
Weintraub, D. A., & Nirenberg, M. J. (2012) · Neurodegenerative Diseases · doi:10.1159/000341996 · Cited by 113
Self-citationReward-based decision making in pathological gambling: The roles of risk and delay
Wiehler, A., & Peters, J. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.09.008 · Cited by 111
“It is known from arkinson’s disease that pharmacological down-regulation DA neuotransmission can lead to increases in impulsive behavior and ven induce PG (Weintraub et al., 2006).”
BackgroundAssessment of psychiatric complications in Parkinson's disease: The SCOPA‐PC
Jeukens‐Visser, M., Verbaan, D., van Rooden, S. M., Stiggelbout, A. M., Marinus, J., & van Hilten, J. J. (2007) · Movement Disorders · doi:10.1002/mds.21696 · Cited by 107
Frontal-striatal abnormalities underlying behaviours in the compulsive-impulsive spectrum
den Heuvel, O. A. V., der Werf, Y. D. V., Verhoef, K. M. W., de Wit, S., Berendse, H. W., Wolters, E. C., Veltman, D. J., & Groenewegen, H. J. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.08.043 · Cited by 105
Metadata
- Authors
- Weintraub, D., Siderowf, A. D., Potenza, M. N., Goveas, J., Morales, K. H., Duda, J. E., Moberg, P. J., & Stern, M. B.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2006-07-01
- Volume
- 63
- Issue
- 7
- Pages
- 969
- ISSN
- 0003-9942 (ISSN-L)
- PMC
- PMC1761054
- OpenAlex
- W2035890213
- Cited by
- 662
- References
- 17
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 12 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 36 · 2019: 38 · 2018: 23 · 2017: 32 · 2016: 40 · 2015: 26 · 2014: 40 · 2013: 45 · 2012: 40
- FWCI
- 30.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K23MH067894)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- Parkinson's disease, impulse control disorders, dopamine agonists, gambling addiction, compulsive buying, compulsive sexual behavior, psychiatric complications, adverse drug reactions, risk factors, dose-response relationship
- MeSH terms
- Pramipexole, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Gambling, Humans, Disruptive, Impulse Control, and Conduct Disorders, Indoles, Male, Middle Aged, Parkinson Disease, Pergolide, Risk Factors, Sexual Behavior, Sexual Dysfunction, Physiological, Thiazoles, Logistic Models, Dopamine Agonists, Benzothiazoles
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