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Ganglionic Acetylcholine Receptor Autoantibody: Oncological, Neurological, and Serological Accompaniments
Open accessAbstract
OBJECTIVE: To describe the clinical utility of the nicotinic ganglionic acetylcholine receptor (alpha3-AChR) autoantibody as a marker of neurological autoimmunity and cancer. DESIGN: Case-control study. SETTING: Mayo Clinic, Rochester, Minnesota. PATIENTS: A total of 15,000 patients seen at Mayo Clinic (2005-2007) and evaluated on a service basis for paraneoplastic neurological autoimmunity for whom clinical information was obtained retrospectively by medical record review as well as 457 neurologically asymptomatic patients or control subjects of whom 173 were healthy, 245 had lung cancer, and 39 had systemic lupus erythematosus or Sjögren syndrome. OUTCOME MEASURES: Neurological, oncological, and serological associations of alpha3-AChR autoantibody seropositivity. RESULTS: Of 15,000 patients tested on a service basis, 1% were seropositive (median, 0.12 nmol/L; range, 0.03-18.8 nmol/L; normal, < or =0.02 nmol/L), 55% were male, and the median age was 65 years. Cancer was found (new or by history) in 24 of 78 patients evaluated for cancer while at Mayo Clinic (30%); 43% had adenocarcinoma (more patients had breast cancer than prostate, lung, and gastrointestinal cancers; each of the latter groups had about the same number of patients). Of 12 patients with high antibody values (> or =1.00 nmol/L), 83% had pandysautonomia. Of 85 patients with medium antibody values (0.10-0.99 nmol/L), neurological presentations were more diverse and included peripheral neuropathies (36%), dysautonomia (20%, usually limited), and encephalopathy (13%). Of 58 patients with low antibody values (0.03-0.09 nmol/L), 54% had a nonautoimmune neurological disorder or no neurological disorder. Of 245 control patients with lung cancer, 7.8% were seropositive. Only 1 of 212 control patients without cancer (0.5%) was seropositive (P < .001). CONCLUSION: The detection of alpha3-AChR autoantibody aids the diagnosis of neurological autoimmunity and cancer.
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“Seropositivity for antiganglionic acetylcholine receptor antibodies is the serological hallmark of autoimmune autonomic ganglionopathy.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [434]
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Metadata
- Authors
- McKeon, A., Lennon, V. A., Lachance, D. H., Fealey, R. D., & Pittock, S. J.
- Affiliations
- Mayo Clinic (US)
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2009-06-01
- Volume
- 66
- Issue
- 6
- Pages
- 735-41
- ISSN
- 0003-9942 (ISSN-L)
- PMC
- PMC3764484
- OpenAlex
- W2166446573
- Cited by
- 168
- References
- 20
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 9 · 2023: 6 · 2022: 9 · 2021: 12 · 2020: 9 · 2019: 10 · 2018: 14 · 2017: 9 · 2016: 8 · 2015: 8 · 2014: 8 · 2013: 15 · 2012: 14
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071209, P01DK068055, R01-DK71209-4, P01-DK-68055)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Clinical Neurology › Myasthenia Gravis and Thymoma
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- immunoglobulins, nicotinic acetylcholine receptors, lung cancer, breast cancer, prostate cancer, autonomic dysfunction, peripheral neuropathy, encephalopathy, autoimmune neurological disorders, cancer screening biomarkers, systemic lupus erythematosus, Sjögren's syndrome
- MeSH terms
- Adenocarcinoma, Aged, Autoantibodies, Autonomic Nervous System Diseases, Encephalitis, Female, Ganglia, Autonomic, Humans, Male, Middle Aged, Neoplasms, Peripheral Nervous System Diseases, Predictive Value of Tests, Receptors, Nicotinic, Retrospective Studies, Biomarkers, Paraneoplastic Syndromes, Nervous System, Primary Dysautonomias
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