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Cited by 1,539

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Hearing Loss and Incident Dementia

Open access
Lin, Frank R., Metter, E. Jeffrey, O’Brien, Richard J., Resnick, Susan M., Zonderman, Alan B., Ferrucci, Luigi·2011·Archives of Neurology

Abstract

OBJECTIVE: To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease (AD). DESIGN: Prospective study of 639 individuals who underwent audiometric testing and were dementia free in 1990 to 1994. Hearing loss was defined by a pure-tone average of hearing thresholds at 0.5, 1, 2, and 4 kHz in the better-hearing ear (normal, <25 dB [n = 455]; mild loss, 25-40 dB [n = 125]; moderate loss, 41-70 dB [n = 53]; and severe loss, >70 dB [n = 6]). Diagnosis of incident dementia was made by consensus diagnostic conference. Cox proportional hazards models were used to model time to incident dementia according to severity of hearing loss and were adjusted for age, sex, race, education, diabetes mellitus, smoking, and hypertension. SETTING: Baltimore Longitudinal Study of Aging. PARTICIPANTS: Six hundred thirty-nine individuals aged 36 to 90 years. MAIN OUTCOME MEASURE: Incident cases of all-cause dementia and AD until May 31, 2008. RESULTS: During a median follow-up of 11.9 years, 58 cases of incident all-cause dementia were diagnosed, of which 37 cases were AD. The risk of incident all-cause dementia increased log linearly with the severity of baseline hearing loss (1.27 per 10-dB loss; 95% confidence interval, 1.06-1.50). Compared with normal hearing, the hazard ratio (95% confidence interval) for incident all-cause dementia was 1.89 (1.00-3.58) for mild hearing loss, 3.00 (1.43-6.30) for moderate hearing loss, and 4.94 (1.09-22.40) for severe hearing loss. The risk of incident AD also increased with baseline hearing loss (1.20 per 10 dB of hearing loss) but with a wider confidence interval (0.94-1.53). CONCLUSIONS: Hearing loss is independently associated with incident all-cause dementia. Whether hearing loss is a marker for early-stage dementia or is actually a modifiable risk factor for dementia deserves further study.

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Metadata

Authors
Lin, F. R., Metter, E. J., O’Brien, R. J., Resnick, S. M., Zonderman, A. B., & Ferrucci, L.
Venue
Archives of Neurology
Published
2011-02-01
Volume
68
Issue
2
Pages
214-20
ISSN
0003-9942 (ISSN-L)
OpenAlex
W2171600170
Cited by
1,539
References
47
FWCI
19.29
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Hearing Loss and Incident Dementia. https://app.cochat.ai/papers/10.1001/archneurol.2010.362
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Lin, F. R., Metter, E. J., O’Brien, R. J., Resnick, S. M., Zonderman, A. B., & Ferrucci, L. (2011). Hearing Loss and Incident Dementia. Archives of Neurology. https://doi.org/10.1001/archneurol.2010.362

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