The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Analysis of Topical Cyclosporine Treatment of Patients With Dry Eye Syndrome<subtitle>Effect on Conjunctival Lymphocytes</subtitle>
Open accessAbstract
OBJECTIVE: To study the effect of topical cyclosporine on lymphocyte activation within the conjunctiva of patients with moderate to severe dry eye syndrome (Sjögren and non-Sjögren). METHODS: Biopsy specimens were obtained at baseline and after 6 months of cyclosporine treatment from eyes of 32 patients with moderate to severe dry eye syndrome; 19 were cyclosporine treated (0.05% cyclosporine, n = 13; 0.1% cyclosporine, n = 6) and 13 were vehicle treated. Within this group there were 12 with Sjögren syndrome and 20 with non-Sjögren syndrome. Biopsy tissue was analyzed using immunohistochemical localization of binding of monoclonal antibodies to lymphocytic markers CD3, CD4, and CD8 as well as lymphocyte activation markers CD11a and HLA-DR. RESULTS: In cyclosporine-treated eyes, biopsy results of conjunctivae showed decreases in the number of cells positive for CD3, CD4, and CD8, while in vehicle-treated eyes, results showed increases in these markers, although these differences were not statistically significant. Following treatment with 0.05% cyclosporine, there was a significant decrease in the number of cells expressing the lymphocyte activation markers CD11a (P<.05) and HLA-DR (P<.05), indicating less activation of lymphocytes as compared with vehicle treatment. Within the Sjögren patient subgroup, those treated with 0.05% cyclosporine also showed a significant decrease in the number of cells positive for CD11a (P<.001) as well as CD3 (P<.03), indicating a reduction in number of activated lymphocytes. CONCLUSION: Treatment of dry eye syndrome with topical cyclosporine significantly reduced the numbers of activated lymphocytes within the conjunctiva. Arch Ophthalmol. 2000;118:1489-1496
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Reliability and Validity of the Ocular Surface Disease Index
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The Pathology of Dry Eye: The Interaction Between the Ocular Surface and Lacrimal Glands
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Topical cyclosporin treatment of keratoconjunctivitis sicca in secondary Sjögren's syndrome
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Simopoulos, A. P. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.07.080 · Cited by 1,143
The Pathophysiology of Dry Eye Disease
Pflugfelder, S. C., & de Paiva, C. S. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2017.07.010 · Cited by 533
Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γ
De Paiva, C. S., Villarreal, A. L., Corrales, R. M., Rahman, H. T., Chang, V. Y., Farley, W. J., Stern, M. E., Niederkorn, J. Y., Li, D.-Q., & Pflugfelder, S. C. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0069 · Cited by 320
Grimaudo, M. A., Pescina, S., Padula, C., Santi, P., Concheiro, A., Alvarez-Lorenzo, C., & Nicoli, S. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1597848 · Cited by 78
Tauber, J., Schechter, B. A., Bacharach, J., Toyos, M. M., Smyth-Medina, R., Weiss, S. L., & Luchs, J. I. (2018) · Clinical ophthalmology · doi:10.2147/opth.s175065 · Cited by 73
Metadata
- Authors
- Kunert, K. S.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 2000-11-01
- Volume
- 118
- Issue
- 11
- Pages
- 1489
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W1992063412
- Cited by
- 337
- References
- 10
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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