Cited by 283Retinal Diseases and TreatmentsFatty Acid Research and HealthNutritional Studies and Diet

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The Relationship of Dietary Lipid Intake and Age-Related Macular Degeneration in a Case-Control Study: AREDS Report No. 20

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Age-Related Eye Disease Study Research Group·2007·Archives of Ophthalmology

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Abstract

OBJECTIVE: To evaluate the association of lipid intake with baseline severity of age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS). METHODS: Age-Related Eye Disease Study participants aged 60 to 80 years at enrollment (N = 4519) provided estimates of habitual nutrient intake through a self-administered semiquantitative food frequency questionnaire. Stereoscopic color fundus photographs were used to categorize participants into 4 AMD severity groups and a control group (participants with <15 small drusen). RESULTS: Dietary total omega-3 long-chain polyunsaturated fatty acid (LCPUFA) intake was inversely associated with neovascular (NV) AMD (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.41-0.90), as was docosahexaenoic acid, a retinal omega-3 LCPUFA (OR, 0.54; 95% CI, 0.36-0.80), comparing highest vs lowest quintile of intake, after adjustment for total energy intake and covariates. Higher fish consumption, both total and broiled/baked, was also inversely associated with NV AMD (OR, 0.61; 95% CI, 0.37-1.00 and OR, 0.65; 95% CI, 0.45-0.93, respectively). Dietary arachidonic acid was directly associated with NV AMD prevalence (OR, 1.54; 95% CI, 1.04-2.29). No statistically significant relationships existed for the other lipids or AMD groups. CONCLUSION: Higher intake of omega-3 LCPUFAs and fish was associated with decreased likelihood of having NV AMD.

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Authors: Age-Related Eye Disease Study Research Group
Affiliations: Emmes (United States) (US)
Corresponding author: Age-Related Eye Disease Study Research Group
Venue: Archives of Ophthalmology
Publisher: American Medical Association (AMA)
Published: 2007-05-01
Volume: 125
Issue: 5
Pages: 671
ISSN: 0003-9950 (ISSN-L)
DOI: 10.1001/archopht.125.5.671
OpenAlex: W1534606983
Cited by: 283
References: 47
Citations by year: 2025: 12 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 20 · 2020: 14 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 15 · 2015: 7 · 2014: 16 · 2013: 20 · 2012: 22
FWCI: 22.78
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Archives of Ophthalmology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (Z99 EY999999)
National Eye Institute (ZIAEY000489)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: age-related macular degeneration, neovascular AMD, dietary fat intake, n-3 long-chain polyunsaturated fatty acids, docosahexaenoic acid, fish consumption, arachidonic acid, drusen, dietary fat
MeSH terms: Aged, Aged, 80 and over, Energy Intake, Diet, Dietary Fats, Unsaturated, Feeding Behavior, Female, Humans, Macular Degeneration, Male, Middle Aged, Surveys and Questionnaires, Models, Statistical, Fatty Acids, Omega-3, Odds Ratio, Case-Control Studies

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The Relationship of Dietary Lipid Intake and Age-Related Macular Degeneration in a Case-Control Study: AREDS Report No. 20

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