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Cited by 283Retinal Diseases and TreatmentsFatty Acid Research and HealthNutritional Studies and Diet

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

The Relationship of Dietary Lipid Intake and Age-Related Macular Degeneration in a Case-Control Study: AREDS Report No. 20

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Age-Related Eye Disease Study Research Group·2007·Archives of Ophthalmology
DOI 10.1001/archopht.125.5.671
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Abstract

OBJECTIVE: To evaluate the association of lipid intake with baseline severity of age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS). METHODS: Age-Related Eye Disease Study participants aged 60 to 80 years at enrollment (N = 4519) provided estimates of habitual nutrient intake through a self-administered semiquantitative food frequency questionnaire. Stereoscopic color fundus photographs were used to categorize participants into 4 AMD severity groups and a control group (participants with <15 small drusen). RESULTS: Dietary total omega-3 long-chain polyunsaturated fatty acid (LCPUFA) intake was inversely associated with neovascular (NV) AMD (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.41-0.90), as was docosahexaenoic acid, a retinal omega-3 LCPUFA (OR, 0.54; 95% CI, 0.36-0.80), comparing highest vs lowest quintile of intake, after adjustment for total energy intake and covariates. Higher fish consumption, both total and broiled/baked, was also inversely associated with NV AMD (OR, 0.61; 95% CI, 0.37-1.00 and OR, 0.65; 95% CI, 0.45-0.93, respectively). Dietary arachidonic acid was directly associated with NV AMD prevalence (OR, 1.54; 95% CI, 1.04-2.29). No statistically significant relationships existed for the other lipids or AMD groups. CONCLUSION: Higher intake of omega-3 LCPUFAs and fish was associated with decreased likelihood of having NV AMD.

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Research works printed but not linked: 11

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  3. The Age-Related Eye Disease Study Research Group. A randomized, placebo- controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No. 8. Arch Ophthalmol. 2001;119:1417-1436.
  4. The Age-Related Eye Disease Study Research Group. Risk factors associated with age-related macular degeneration: a case-control study in the Age-Related Eye Disease Study. Age-Related Eye Disease Study report number 3. Ophthalmology. 2000;107:2224-2232.
  5. The Age-Related Eye Disease Study Research Group. The Age-Related Eye Dis- ease Study system for classifying age-related macular degeneration from ste- reoscopic color fundus photographs: the Age-Related Eye Disease Study report number 6. Am J Ophthalmol. 2001;132:668-681.
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Metadata

Authors
Age-Related Eye Disease Study Research Group
Affiliations
Emmes (United States) (US)
Corresponding author
Age-Related Eye Disease Study Research Group
Venue
Archives of Ophthalmology
Publisher
American Medical Association (AMA)
Published
2007-05-01
Volume
125
Issue
5
Pages
671
ISSN
0003-9950 (ISSN-L)
DOI
10.1001/archopht.125.5.671
OpenAlex
W1534606983
Cited by
283
References
47
Citations by year
2025: 12 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 20 · 2020: 14 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 15 · 2015: 7 · 2014: 16 · 2013: 20 · 2012: 22
FWCI
22.78
Type
journal article
Language
en
Open access
Locations
  • Archives of Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (Z99 EY999999)
  • National Eye Institute (ZIAEY000489)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
age-related macular degeneration, neovascular AMD, dietary fat intake, n-3 long-chain polyunsaturated fatty acids, docosahexaenoic acid, fish consumption, arachidonic acid, drusen, dietary fat
MeSH terms
Aged, Aged, 80 and over, Energy Intake, Diet, Dietary Fats, Unsaturated, Feeding Behavior, Female, Humans, Macular Degeneration, Male, Middle Aged, Surveys and Questionnaires, Models, Statistical, Fatty Acids, Omega-3, Odds Ratio, Case-Control Studies

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