CoChat
Sign Up
Cited by 229Retinal Diseases and TreatmentsRetinal and Macular SurgeryOcular Diseases and Behçet’s Syndrome

Argon Laser Photocoagulation for Neovascular Maculopathy: Three-Year Results From Randomized Clinical Trials

·1986·Archives of Ophthalmology
DOI 10.1001/archopht.1986.01050170084028
Open this paper in CoChat — free account

Abstract

• The Macular Photocoagulation Study randomized controlled clinical trials designed to determine whether argon laser photocoagulation is effective for preventing or delaying severe visual loss in eyes with an extrafoveal choroidal neovascular membrane secondary to senile macular degeneration (Senile Macular Degeneration Study [SMDS]), ocular histoplasmosis (Ocular Histoplasmosis Study [OHS]), or idiopathic neovascularization (Idiopathic Neovascularization Study [INVS]). Eligible patients were assigned randomly to a "treatment" group or to a "no treatment" group until recruitment was terminated in 1982 (SMDS) and 1983 (OHS and INVS) because of demonstrated short-term treatment benefit. As of Aug 31, 1985, three or more years of scheduled follow-up examinations had been completed for 208 (88%) of 236 eyes in the SMDS, 203 (77%) of 262 eyes in the OHS, and 51 (76%) of 67 eyes in the INVS. The relative risk of experiencing severe loss of vision after three years in eyes initially assigned to the no treatment group in comparison with eyes assigned to the argon laser photocoagulation group was 1.4 in the SMDS (95% confidence interval [CI]: 1.1 to 1.9), 5.5 in the OHS (95% CI: 3.9 to 10.8), and 2.3 in the INVS (95% CI: 0.8 to 6.5). The beneficial effects of argon laser treatment have persisted in all three studies in spite of the fact that some eyes in the "no treatment" groups were treated later in their clinical course as a result of the evidence of early benefit. Follow-up of all patients continues so that treatment effectiveness over a five-year period can be assessed.

Integrity signals

Registry

Crossref · 10.1001/archopht.1986.01050170084028

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The Macular Photocoagulation Study showed a reduction in vision loss associated with thermal laser photocoagulation, provided the neovascular lesion had well-demarcated (classic) boundaries.

    “In the 1980s, the Macular Photo-coagulation Study159,160 showed a reduction in vision loss associated with thermal laser photocoagulation, provided the neovascular lesion had well-demarcated (classic) boundaries.”

    From Age-related macular degeneration (2008) · cites this paper as [159]

Cited by

Sorted by citations

Related

Venue
Archives of Ophthalmology
Publisher
American Medical Association (AMA)
Published
1986-05-01
Volume
104
Issue
5
Pages
694
ISSN
0003-9950 (ISSN-L)
DOI
10.1001/archopht.1986.01050170084028
OpenAlex
W4243337108
Cited by
227
References
0
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 14
FWCI
9.32
Type
journal article
Language
en
Open access
closed
Locations
Archives of Ophthalmology (publishedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
argon laser photocoagulation, choroidal neovascularization, senile macular degeneration, ocular histoplasmosis, macular photocoagulation, blindness prevention, long-term treatment effectiveness

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review