Precocious Puberty Following Severe Head Trauma
Abstract
True precocious puberty is frequently secondary to intrinsic central nervous system pathology, but is rare following external head trauma. We describe two children who developed precocious puberty within three months of severe exogenous head trauma. Infusion of luteinizing hormone releasing factor induced a prompt rise in circulating gonadotropin concentrations and established that their sexual precocity was the result of premature activation of the hypothalamic-pituitary axis. While the precise mechanism by which exogenous head trauma causes precocious puberty remains unknown, the clinical features of these children's disorders are consistent with the hypothesis that extra-hypothalamic areas restrain pituitary gonadotropin secretion before puberty and that damage to these areas can result in precocious puberty.
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In 26 children tested after TBI, stimulated cortisol levels were lower than in healthy controls using insulin tolerance testing.
“In 26 children tested after TBI, stimulated cortisol levels were lower than in healthy controls, using insulin tolerance testing [36].”
From Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury (2015) · cites this paper as [36]
Case reports have documented pituitary dysfunction including precocious puberty in children after TBI.
“Case reports have documented pituitary dysfunction including precocious puberty in children [36].”
From Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury (2015) · cites this paper as [36]
Cites
Variations in pattern of pubertal changes in girls
Marshall, W. A., & Tanner, J. M. (1969) · Archives of Disease in Childhood · doi:10.1136/adc.44.235.291 · Cited by 5,963 · see citing works
Variations in the pattern of pubertal changes in boys
Marshall, W. A., & Tanner, J. M. (1970) · Archives of Disease in Childhood · doi:10.1136/adc.45.239.13 · Cited by 5,147 · see citing works
FALL IN NOCTURNAL SERUM MELATONIN DURING PREPUBERTY AND PUBESCENCE
Waldhauser, F., Frisch, H., Waldhauser, M., Weiszenbacher, G., Zeitlhuber, U., & Wurtman, R. J. (1984) · The Lancet · doi:10.1016/s0140-6736(84)90412-4 · Cited by 303 · see citing works
Roth, J., Kelch, R. P., Kaplan, S. L., & Grumbach, M. M. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-6-926 · Cited by 253 · see citing works
Control of the Onset of Puberty.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-81-5-727_2 · Cited by 241 · see citing works
Sigurjonsdottir, T. J. (1968) · American journal of diseases of children · doi:10.1001/archpedi.1968.02100010311003 · Cited by 166 · see citing works
Melatonin, the pineal gland and human puberty
Silman, R. E., Leone, R., HOOPER, R. J. L., & Preece, M. A. (1979) · Nature · doi:10.1038/282301a0 · Cited by 163 · see citing works
Martin, J. E., Engel, J. N., & Klein, D. C. (1977) · Endocrinology · doi:10.1210/endo-100-3-675 · Cited by 95 · see citing works
Pubertal development: Normal, precocious and delayed
DUCHARME, J. R., & COLLU, R. (1982) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(82)80038-8 · Cited by 39 · see citing works
Root, A. W. (1973) · The Journal of Pediatrics · doi:10.1016/s0022-3476(73)80475-5 · Cited by 25 · see citing works
Precocious puberty and non-accidental injury.
McKiernan, J. (1978) · BMJ · doi:10.1136/bmj.2.6144.1059 · Cited by 7 · see citing works
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(1991) · PubMed · Cited by 85 · see citing works
Endocrine dysfunction following traumatic brain injury in children
Kaulfers, A.-M. D., Backeljauw, P. F., Reifschneider, K., Blum, S., Michaud, L., Weiss, M., & Rose, S. R. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.07.004 · Cited by 84 · see citing works
Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury
Reifschneider, K., Auble, B., & Rose, S. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4081536 · Cited by 66 · see citing works
“In 26 children tested after TBI, stimulated cortisol levels were lower than in healthy controls, using insulin tolerance testing [36].”
BackgroundAcerini, C. L., Tasker, R. C., Bellone, S., Bona, G., Thompson, C. J., & Savage, M. O. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02284 · Cited by 65 · see citing works
Hamartoma of the tuber cinereum: a comparison of MR and CT findings in four cases.
Burton, E. M., Ball, W. S., Crone, K. R., & Dolan, L. M. (1989) · PubMed Central · Cited by 55 · see citing works
Hurvitz, E. A., Mandac, B. R., Davidoff, G. N., Johnson, J. H., & Nelson, V. S. (1992) · PubMed · Cited by 52 · see citing works
Non-neoplastic diseases of the testis
Nistal, M., & Paniagua, R. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-01970-5.50014-2 · Cited by 50 · see citing works
Traumatic brain injury induced hypothalamic-pituitary dysfunction: a paediatric perspective
Acerini, C. L., & Tasker, R. C. (2007) · Pituitary · doi:10.1007/s11102-007-0052-8 · Cited by 46 · see citing works
Precocious puberty after traumatic brain injury
Sockalosky, J. J., Kriel, R. L., Krach, L. E., & Sheehan, M. (1987) · The Journal of Pediatrics · doi:10.1016/s0022-3476(87)80497-3 · Cited by 41 · see citing works
Neonatal encephalopathy: An indicator of early sexual maturation in girls
Robertson, C. M. T., Morrish, D. W., Wheler, G. H. T., & Grace, M. G. A. (1990) · Pediatric Neurology · doi:10.1016/0887-8994(90)90042-y · Cited by 29 · see citing works
Neurobiology of puberty and its disorders
Witchel, S. F., & Plant, T. M. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820683-6.00033-6 · Cited by 23 · see citing works
Precocious puberty in children after traumatic brain injury
Blendonohy, P. M., & Philip, P. A. (1991) · Brain Injury · doi:10.3109/02699059108998513 · Cited by 19 · see citing works
Isosexual precocity: current concepts and recent advances
Wallach, E. E., Root, A. W., & Shulman, D. I. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49388-x · Cited by 17 · see citing works
Brain Injury and Neuroendocrine Function
Eledrisi, M. S., Urban, R. J., & Lieberman, S. A. (2001) · The Endocrinologist · doi:10.1097/00019616-200107000-00005 · Cited by 9 · see citing works
A taxonomy of neurobehavioral functions applied to neuropsychological assessment after head injury
Parker, R. S. (1996) · Neuropsychology Review · doi:10.1007/bf01874895 · Cited by 7 · see citing works
Precocious puberty following head injury
Maxwell, M., Karacostas, D., Ellenbogen, R. G., Brzezinski, A., Zervas, N. T., & Black, P. M. (1990) · Journal of neurosurgery · doi:10.3171/jns.1990.73.1.0123 · Cited by 6 · see citing works
What is known about sexual health after pediatric acquired brain injury: A scoping review
Simpson, G. K., Simons, M., Bates, A., & Gan, C. (2017) · Neurorehabilitation · doi:10.3233/nre-172197 · Cited by 5 · see citing works
Nonneoplastic Diseases of the Testis
Nistal, M., Paniagua, R., & González‐Peramato, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-54941-7.00012-8 · Cited by 5 · see citing works
Endocrine Abnormalities in Children with Traumatic Brain Injury at a Tertiary Care Center
Rao, A., Laghari, A. A., Bari, I., Khalid, M. U., Kirmani, S., & Bari, M. E. (2023) · Cureus · doi:10.7759/cureus.34131 · Cited by 4 · see citing works
Nistal, M., Paniagua, R., González‐Peramato, P., & Reyes‐Múgica, M. (2014) · Pediatric and Developmental Pathology · doi:10.2350/14-05-1494-pb.1 · Cited by 4 · see citing works
Hamartoma of the Tuber Cinereum
Cattin, F. (2016) · Springer eBooks · doi:10.1007/978-3-319-29043-0_38 · Cited by 2 · see citing works
Vorzeitige Geschlechtsreife bei Mädchen
Hauffa, B. P. (1987) · Springer eBooks · doi:10.1007/978-3-642-72662-0_11 · Cited by 1 · see citing works
Managing the Menstrual Cycle in Women with Disabilities
Welner, S. L. (1999) · Sexuality and Disability · doi:10.1023/a:1022172720898 · Cited by 1 · see citing works
Endocrinal abnormalities following head injury
Gupta, D. K., & Mahapatra, A. (2004) · Indian Journal of Neurotrauma · doi:10.1016/s0973-0508(04)80002-9
Does residual virus replication during successful HAART lead to HIV-1 genetic evolution?
Aquaro, S., Svicher, V., & Perno, C. F. (2006) · PubMed
Smith, A. M., & Grayson, B. E. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.25364
Nonneoplastic diseases of the testis
Nistal, M., Paniagua, R., & González‐Peramato, P. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4327-8.00012-7
- Authors
- Shaul, P. W.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Shaul, Philip W.
- ORCID
- Shaul, Philip W.
- Venue
- Archives of Pediatrics & Adolescent Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1985-05-01
- Volume
- 139
- Issue
- 5
- Pages
- 467
- ISSN
- 1072-4710 (ISSN-L)
- OpenAlex
- W2082437564
- Cited by
- 27
- References
- 11
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Pediatrics and Adolescent Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (RR00123)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- precocious puberty, head trauma, traumatic brain injury, hypothalamic-pituitary-gonadal axis, gonadotropin secretion, children, sexual maturation
- MeSH terms
- Child, Dehydroepiandrosterone, Estradiol, Female, Craniocerebral Trauma, Humans, Gonadotropin-Releasing Hormone, Male, Pituitary Gland, Prolactin, Puberty, Precocious, Radioimmunoassay, Testosterone
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