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Cited by 87Attention Deficit Hyperactivity DisorderSleep and related disordersCircadian rhythm and melatonin

Effects of Methylphenidate on Sleep in Children With Attention-Deficit Hyperactivity Disorder: An Activity Monitor Study

Tirosh, Emanuel·1993·American Journal of Diseases of Children
DOI 10.1001/archpedi.1993.02160360055018
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Abstract

OBJECTIVE: To assess the effects of methylphenidate hydrochloride on sleep patterns in children diagnosed as having attention-deficit hyperactivity disorder (ADHD). DESIGN: A double-blind, controlled drug-placebo cross-over design. SETTING: Home. SUBJECTS: Ten children (aged 6 years 9 months to 12 years & months) diagnosed as having ADHD were consecutively recruited and compared with age- and sex-matched normal controls. TREATMENT: Methylphenidate hydrochloride (0.3 to 0.4 mg/kg) or placebo was administered at 7:30 AM. MEASUREMENTS AND RESULTS: Each child underwent activity monitoring at home during 6 days of no treatment (baseline) followed by placebo and methylphenidate treatment. The results of the three trial stages, as well as those of the 20 age- and sex-matched normal controls, were compared. A shorter total sleep duration was evident during the methylphenidate treatment compared with that of baseline and placebo treatment. The amount of quiet sleep was lower (however, not significantly) among the study group compared with controls, whereas no such difference was noted during methylphenidate treatment. Night-to-night sleep pattern stability was found. No other differences were found either between children with ADHD and controls or between on and off stages of methylphenidate treatment. CONCLUSIONS: These results support the notion that ADHD is a centrally generated disorder attributable to hypoarousal, which subsequently stimulates motor overactivity. Methylphenidate does not appear to affect sleep patterns adversely and possibly normalizes them in patients with ADHD.

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Crossref · 10.1001/archpedi.1993.02160360055018

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  • A smaller, non-actigraphic study suggested that methylphenidate does not appear to affect sleep patterns adversely and possibly normalizes them in patients with ADHD.

    “However, a smaller, non-actigraphic study suggested that methylphenidate does not appear to affect sleep patterns adversely and possibly normalizes them in patients with ADHD [142].”

    From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [142]

  • Among individual sleep parameters, difficulty falling asleep continues to differ significantly between children with or without medication after the severity of ADHD symptoms has been controlled for.

    “Among individual sleep parameters, difficulty falling asleep continues to differ significantly between children with or without medication after the severity of ADHD symptoms has been controlled for [142].”

    From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [142]

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Authors
Tirosh, E.
Affiliations
Bnai Zion Medical Center (IL)
Corresponding author
Tirosh, Emanuel
ORCID
Tirosh, Emanuel
Venue
American Journal of Diseases of Children
Publisher
American Medical Association (AMA)
Published
1993-12-01
Volume
147
Issue
12
Pages
1313
ISSN
0002-922X (ISSN-L)
DOI
10.1001/archpedi.1993.02160360055018
OpenAlex
W1966096074
Cited by
87
References
25
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 5 · 2013: 1 · 2012: 2
FWCI
1.30
Type
journal article
Language
en
Open access
closed
Locations
  • American journal of diseases of children (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
methylphenidate, attention deficit hyperactivity disorder, sleep patterns, sleep duration, quiet sleep, hypoarousal, children
MeSH terms
Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Child, Double-Blind Method, Female, Humans, Male, Methylphenidate, Sleep, Polysomnography

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