Actigraphic Monitoring During Sleep of Children With ADHD on Methylphenidate and Placebo
Abstract
Objective Sleep disturbances appear as a comorbid condition in children with attention-deficit/hyperactivity disorder. The aim of this study was to investigate the relationship of activity levels during sleep and therapeutic response to methylphenidate (MPH).Method Nightly sleep actigraphic recordings during a double-blind, placebo-controlled, crossover clinical study (1-week of 0.5 mg/kg MPH; 1-week of placebo) were obtained on 44 children, 6 to 12 years old, diagnosed with attention-deficit/hyperactivity disorder (DSM-IV).Results Significant (p <.005) differences between the conditions were found in several software-computed parameters: sleep onset latency (MPH, 39.3 minutes; placebo, 28.2 minutes), sleep efficiency (MPH, 78.0%; placebo, 80.4%), total sleep time (MPH, 7 hours; 57 minutes; placebo, 8 hours, 16 minutes). No significant differences on any of these measures were found among the 26 subjects who showed a moderate or large global improvement on MPH over placebo compared with 18 subjects who showed mild or no clinical improvement.Conclusions MPH, given twice daily, induces a slight but significant sleep disturbance. Motor activity levels during sleep did not differentiate children who responded to MPH from those who did not respond. This suggests that responders to MPH treatment do not experience greater sleep disturbances than nonresponders, at least at the dose studied.
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In a placebo-controlled cross-over actigraphic monitoring study of 44 children, sleep latency was similar in children with ADHD on methylphenidate versus placebo, but total sleep duration was shorter with methylphenidate than placebo.
“In a placebo-controlled cross-over actigraphic monitoring study of 44 children, sleep latency was similar in children with ADHD on methylphenidate versus placebo, but total sleep duration was shorter with methylphenidate than placebo [125].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [125]
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- Authors
- SCHWARTZ, G., AMOR, L. B., GRIZENKO, N., LAGEIX, P., BARON, C., BOIVIN, D. B., & JOOBER, R.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Corresponding author
- JOOBER, RIDHA
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 43
- Issue
- 10
- Pages
- 1276-1282
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2090634557
- Cited by
- 70
- References
- 41
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 5 · 2012: 6
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- attention deficit hyperactivity disorder, methylphenidate, sleep disorders, actigraphy, sleep latency, sleep efficiency, total sleep time, treatment response, children
- MeSH terms
- Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Data Collection, Double-Blind Method, Female, Humans, Male, Methylphenidate, Movement, Placebos, Sleep Wake Disorders, Cross-Over Studies
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