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Cited by 153Pregnancy and Medication ImpactPrenatal Substance Exposure EffectsMaternal Mental Health During Pregnancy and Postpartum

Selective Serotonin Reuptake Inhibitor Exposure In Utero and Pregnancy Outcomes

Lund, Najaaraq, Pedersen, Lars H., Henriksen, Tine Brink·2009·Archives of Pediatrics & Adolescent Medicine
DOI 10.1001/archpediatrics.2009.164
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Abstract

OBJECTIVE: To investigate the effect of intrauterine selective serotonin reuptake inhibitor (SSRI) exposure on pregnancy outcomes. DESIGN: Prospective cohort study. SETTING: Department of Obstetrics, Aarhus University Hospital, Aarhus, Denmark. PARTICIPANTS: Pregnant women receiving prenatal care in our hospital from 1989 to 2006. MAIN EXPOSURE: Maternal SSRI use during pregnancy. OUTCOME MEASURES: Gestational age, birth weight, head circumference, 5-minute Apgar score, and admission to the neonatal intensive care unit. RESULTS: Three hundred twenty-nine pregnant women reported treatment with SSRIs, 4902 were not treated with SSRIs but had a history of psychiatric illness, and 51 770 reported no history of psychiatric illness. Gestational age was 5 days (95% confidence interval [CI], -6 to -3) shorter and the odds ratio (OR) for preterm birth was 2.0 (95% CI, 1.3-3.2) in the women exposed to SSRIs compared with women with no history of psychiatric illness. In utero-exposed newborns had increased risk of admission to the neonatal intensive care unit (OR, 2.4; 95% CI, 1.7-3.4) and of 5-minute Apgar scores of less than 8 (OR, 4.4; 95% CI, 2.6-7.6) compared with those not exposed. Head circumference and birth weight did not differ between infants in the exposed and unexposed groups. The results were similar when compared with infants of women with a psychiatric history. CONCLUSIONS: Exposure to SSRIs during pregnancy was associated with an increased risk of preterm delivery, a low 5-minute Apgar score, and neonatal intensive care unit admission, which was not explained by lower Apgar scores or gestational age. The study justifies increased awareness to the possible effects of intrauterine exposure to antidepressants.

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  • Among antidepressants, SSRIs and, possibly, serotonin and noradrenaline reuptake inhibitors have been associated with preterm labor, respiratory distress, serotonin rebound syndrome, pulmonary hypertension and feeding problems in the neonate.

    “Among AD, SSRIs and, possibly, serotonin and noradrenaline reuptake inhibitors (SNRIs) have been associated with preterm labor, respiratory distress, serotonin rebound syndrome, pulmonary hypertension and feeding problems in the neonate (557-559).”

    From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [557]

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Authors
Lund, N., Pedersen, L. H., & Henriksen, T. B.
Affiliations
Bandim Health Project (GW)
ORCID
Venue
Archives of Pediatrics & Adolescent Medicine
Publisher
American Medical Association (AMA)
Published
2009-10-05
Volume
163
Issue
10
Pages
949
ISSN
1072-4710 (ISSN-L)
DOI
10.1001/archpediatrics.2009.164
OpenAlex
W2048933622
Cited by
153
References
52
Citations by year
2025: 1 · 2024: 2 · 2023: 6 · 2022: 2 · 2020: 3 · 2019: 3 · 2018: 9 · 2017: 5 · 2016: 12 · 2015: 14 · 2014: 10 · 2013: 20 · 2012: 20
FWCI
22.08
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Pediatrics and Adolescent Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Sundhed og Sygdom, Det Frie Forskningsråd
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
selective serotonin reuptake inhibitors, prenatal antidepressant exposure, pregnancy outcomes, preterm birth, Apgar score, neonatal intensive care admission, birth weight, head circumference, gestational age, prenatal exposure
MeSH terms
Antidepressive Agents, Denmark, Depressive Disorder, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome, Prenatal Exposure Delayed Effects, Prospective Studies, Multivariate Analysis, Linear Models, Logistic Models, Selective Serotonin Reuptake Inhibitors

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