Predicting Prediabetes and Diabetes: Can We Do It? Is It Worth It?
Open accessAbstract
Atherosclerosis begins in youth, and the extent of coronary lesions in adolescents is associated with individual and combined levels of risk factors including lipids, smoking, blood pressure, obesity, and-the focus of this editorial-hyperglycemia.1,2 These risk factors tend to track from childhood to adulthood; children with elevated risk factor levels tend to retain them as they grow, thus becoming adults at higher risk of cardiovascular disease.Of these risk factors, hyperglycemia is a special case.Hyperglycemia heralds diabetes.Diabetes is not only a risk factor for heart and stroke but, because of its myriad vascular and neurologic effects, it is also a major cause of renal disease, blindness, amputations, dental disease, pregnancy complications, peripheral neuropathy, and sexual dysfunction.3 With the obesity epidemic, type 2 diabetes is becoming more common in the pediatrician's office in the West, and probably will soon in the developing world, where rates of adult diabetes are skyrocketing.
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Coronary lesion extent in adolescents is associated with risk factors such as lipids, smoking, blood pressure, obesity, and hyperglycemia.
“the extent of coronary lesions in adolescents is associated with risk factors including lipids, smoking, blood pressure, obesity, and hyperglycemia”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [197]
Childhood metabolic syndrome rarely reverses, leading to high risk of adult cardiovascular disease.
“Reversibility of childhood metabolic syndrome is rare, thus leading to high risk of adulthood cardiovascular disease”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [197]
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Cites
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International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes
The International Expert Committee (2009) · Diabetes Care · doi:10.2337/dc09-9033 · Cited by 3,185 · see citing works
Global Prevalence of Diabetes: Estimates for the Year 2000 and Projections for 2030
Rathmann, W., & Giani, G. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2568 · Cited by 2,008 · see citing works
Greenland, P. (2007) · Statistics in Medicine · doi:10.1002/sim.2976 · Cited by 1,300 · see citing works
CORONARY DISEASE AMONG UNITED STATES SOLDIERS KILLED IN ACTION IN KOREA
Enos, W. F. (1953) · JAMA · doi:10.1001/jama.1953.03690120006002 · Cited by 890 · see citing works
SEARCH for Diabetes in Youth Study Group (2006) · Pediatrics · doi:10.1542/peds.2006-0690 · Cited by 726 · see citing works
Stockman, J. A. (2008) · Yearbook of Pediatrics · doi:10.1016/s0084-3954(08)70503-7 · Cited by 595 · see citing works
Mcgill, H., Mcmahan, C., & Gidding, S. (2008) · Circulation · doi:10.1161/circulationaha.107.717033 · Cited by 575 · see citing works
A Comparison of C/B Ratios from Studies Using Receiver Operating Characteristic Curve Analysis
Cantor, S. B., Sun, C. C., Tortolero‐Luna, G., Richards-Kortum, R. R., & Follen, M. M. (1999) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00075-x · Cited by 218 · see citing works
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Lowering the Cut Point for Impaired Fasting Glucose
Schriger, D. L., & Lorber, B. (2004) · Diabetes Care · doi:10.2337/diacare.27.2.592 · Cited by 66 · see citing works
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Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575 · see citing works
- Authors
- Gillman, M. W.
- Affiliations
- Harvard University (US)
- Corresponding author
- Gillman, Matthew W.
- ORCID
- Gillman, Matthew W.
- Venue
- Archives of Pediatrics & Adolescent Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2010-02-01
- Volume
- 164
- Issue
- 2
- Pages
- 198-9
- ISSN
- 1072-4710 (ISSN-L)
- PMC
- PMC4350017
- OpenAlex
- W1971238727
- Cited by
- 5
- References
- 12
- Citations by year
- 2012: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Pediatrics and Adolescent Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (K24HL068041)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK040561)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- prediabetes, type 2 diabetes, hyperglycemia, atherosclerosis, cardiovascular risk factors, adolescents, childhood obesity, diabetes prediction
- MeSH terms
- Blood Glucose, Cardiovascular Diseases, Humans, Hyperglycemia, Prediabetic State, Predictive Value of Tests, Risk Factors, Prevalence
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