The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Prospective Multicenter Study of Viral Etiology and Hospital Length of Stay in Children With Severe Bronchiolitis
Open accessAbstract
OBJECTIVE: To determine whether hospital length of stay(LOS) for acute bronchiolitis is influenced by the infecting pathogen. DESIGN: A prospective observational cohort study was performed during 3 consecutive years. SETTING: Sixteen US hospitals participated in the study. PARTICIPANTS: Children younger than 2 years hospitalized with bronchiolitis were included. MAIN EXPOSURE: The results of nasopharyngeal aspirate polymerase chain reaction pathogen testing served as the main exposure. MAIN OUTCOME MEASURE: Hospital LOS was determined. RESULTS: Of 2207 participants, 72.0% had respiratory syncytial virus (RSV) and 25.6% had human rhinovirus(HRV); the incidence of each of the other viruses and bacteria was 7.8% or less. Multiple pathogen infections were present in 29.8% of the children. There were 1866 children(84.5%) with RSV and/or HRV. Among these 1866 children, the median age was 4 months and 59.5% were male. The median LOS was 2 days (interquartile range,1-4 days). Compared with children who had only RSV,an LOS of 3 or more days was less likely among children with HRV alone (adjusted odds ratio [AOR], 0.36; 95%CI, 0.20-0.63; P.001) and those with HRV plus non-RSV pathogens (AOR, 0.39; 95% CI, 0.23-0.66; P.001)but more likely among children with RSV plus HRV(AOR,1.33; 95% CI, 1.02-1.73; P=.04), controlling for 15 demographic and clinical factors. CONCLUSIONS: In this multicenter study of children hospitalized with bronchiolitis, RSV was the most common virus detected, but HRV was detected in one-quarter of the children. Since 1 in 3 children had multiple virus infections and HRV was associated with LOS, these data challenge the effectiveness of current RSV-based cohorting practices, the sporadic testing for HRV in bronchiolitis research, and current thinking that the infectious etiology of severe bronchiolitis does not affect short-term outcomes.
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Cites
Bronchiolitis-Associated Hospitalizations Among US Children, 1980-1996
Shay, D. K. (1999) · JAMA · doi:10.1001/jama.282.15.1440 · Cited by 1,385
Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children
Jackson, D. J., Gangnon, R. E., Evans, M. D., Roberg, K. A., Anderson, E. L., Pappas, T. E., Printz, M. C., Lee, W.-M., Shult, P. A., Reisdorf, E., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200802-309oc · Cited by 1,317
Wark, P. A. B., Johnston, S. L., Bucchieri, F., Powell, R., Puddicombe, S., Laza-Stanca, V., Holgate, S. T., & Davies, D. E. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041901 · Cited by 1,235
The major human rhinovirus receptor is ICAM-1
Greve, J. M., Davis, G., Meyer, A. M., Forte, C. P., Yost, S. C., Marlor, C. W., Kamarck, M. E., & McClelland, A. (1989) · Cell · doi:10.1016/0092-8674(89)90688-0 · Cited by 1,148
Diagnosis and Management of Bronchiolitis
Bronchiolitis, S. O. D. A. M. O. (2006) · Pediatrics · doi:10.1542/peds.2006-2223 · Cited by 1,062
Role of deficient type III interferon-λ production in asthma exacerbations
Contoli, M., Message, S. D., Laza-Stanca, V., Edwards, M. R., Wark, P. A. B., Bartlett, N. W., Kebadze, T., Mallia, P., Stanciu, L. A., Parker, H. L., et al. (2006) · Nature Medicine · doi:10.1038/nm1462 · Cited by 1,006
Kusel, M. M. H., de Klerk, N. H., Kebadze, T., Vohma, V., Holt, P. G., Johnston, S. L., & Sly, P. D. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.669 · Cited by 748
Rhinovirus illnesses during infancy predict subsequent childhood wheezing
Lemanske, R. F., Jackson, D. J., Gangnon, R. E., Evans, M. D., Li, Z., Shult, P. A., Kirk, C. J., Reisdorf, E., Roberg, K. A., Anderson, E. L., et al. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.06.024 · Cited by 735
Semple, M. G., Cowell, A., Dove, W., Greensill, J., McNamara, P. S., Halfhide, C., Shears, P., Smyth, R. L., & Hart, C. A. (2005) · The Journal of Infectious Diseases · doi:10.1086/426457 · Cited by 430
Rhinovirus-induced wheezing in infancy—the first sign of childhood asthma?
Kotaniemi-Syrjänen, A., Vainionpää, R., Reijonen, T. M., Waris, M., Korhonen, K., & Korppi, M. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.33 · Cited by 403
Cited by
Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis
Ralston, S. L., Lieberthal, A. S., Meissner, H. C., Alverson, B. K., Baley, J. E., Gadomski, A. M., Johnson, D. W., Light, M. J., Maraqa, N. F., Mendonca, E. A., et al. (2014) · Pediatrics · doi:10.1542/peds.2014-2742 · Cited by 1,733
Miller, J. M., Binnicker, M. J., Campbell, S., Carroll, K. C., Chapin, K. C., Gilligan, P. H., Gonzalez, M. D., Jerris, R. C., Kehl, S. C., Patel, R., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy381 · Cited by 641
Florin, T. A., Plint, A. C., & Zorc, J. J. (2017) · The Lancet · doi:10.1016/s0140-6736(16)30951-5 · Cited by 452
Metadata
- Authors
- Piedra, P. A.
- Venue
- Archives of Pediatrics & Adolescent Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2012-08-01
- Volume
- 166
- Issue
- 8
- Pages
- 700
- ISSN
- 1072-4710 (ISSN-L)
- OpenAlex
- W2122696384
- Cited by
- 398
- References
- 38
- FWCI
- 18.53
- Type
- journal article
- Language
- en
- Open access
- green
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