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The Comparative Antidepressant Value of L-Tryptophan and Imipramine With and Without Attempted Potentiation by Liothyronine
Abstract
In a trial lasting four weeks patients responded equally well to imipramine (150 mg daily) or to L-tryptophan (9 gm daily). Patients who received a small dose of L-triiodothyronine (T3, liothyronine sodium (25μg daily for the first two weeks of treatment) in addition to imipramine showed a significantly better therapeutic response than patients who received either imipramine or tryptophan alone. Liothyronine did not enhance the therapeutic response to L-tryptophan. None of the treatments tested seemed to benefit any particular symptom of depression differenntially. In particular, L-tryptophan had no specific effect on the sleep deficit of the syndrome. Liothyronine appeared to diminish the side effects of both imipramine and L-tryptophan in both men and women.
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Cited by
"Serotonin Depression"—A Biochemical Subgroup Within the Affective Disorders?
Åsberg, M., Thorén, P., Traskman, L., Bertilsson, L., & Ringberger, V. (1976) · Science · doi:10.1126/science.1246632 · Cited by 682
Charney, D. S. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780350094011 · Cited by 649
The Link between Thyroid Function and Depression
Hage, M. P., & Azar, S. T. (2012) · Journal of Thyroid Research · doi:10.1155/2012/590648 · Cited by 549
Can antidepressants cause mania and worsen the course of affective illness?
(1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.11.1403 · Cited by 398
Akiskal, H. S., & McKinney, W. T. (1973) · Science · doi:10.1126/science.182.4107.20 · Cited by 389
Metadata
- Authors
- Coppen, A.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1972-03-01
- Volume
- 26
- Issue
- 3
- Pages
- 234
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2036072463
- Cited by
- 245
- References
- 0
- FWCI
- 22.66
- Type
- journal article
- Language
- en
- Open access
- closed
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