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Cited by 398

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Can antidepressants cause mania and worsen the course of affective illness?

·1987·American Journal of Psychiatry
DOI 10.1176/ajp.144.11.1403
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Abstract

Several investigators have recently challenged the belief that antidepressants can precipitate mania or rapid cycling between mania and depression. With one exception, there appear to be no placebo-controlled studies of switches into mania in bipolar patients during antidepressant treatment. Patients most likely to switch into mania during antidepressant therapy have probably been excluded from maintenance treatment studies and are probably overrepresented in studies at special research facilities. On balance, the available evidence suggests that some bipolar patients become manic, and a few experience rapid cycling, when they are treated with antidepressants. The prevention of these responses will require further research on risk factors and on the antimanic efficacy of coadministered lithium or other mood stabilizers.

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Crossref · 10.1176/ajp.144.11.1403

Cites

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Metadata

Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
1987-11-01
Volume
144
Issue
11
Pages
1403-1411
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.144.11.1403
OpenAlex
W12210335
Cited by
398
References
43
FWCI
11.52
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Can antidepressants cause mania and worsen the course of affective illness? https://app.cochat.ai/papers/10.1176/ajp.144.11.1403
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Can antidepressants cause mania and worsen the course of affective illness? (1987). American Journal of Psychiatry. https://doi.org/10.1176/ajp.144.11.1403

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.