The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Clinical Implications of Imipramine Plasma Levels for Depressive Illness
Abstract
Sixty depressed nonschizophrenic patients were admitted to a research unit. Following one drug-free week and one week of placebo, patients received 3.5 mg/kg of imipramine hydrochloride for 28 days. Plasma levels of imipramine and its metabolite desipramine hydrochloride (desmethylimipramine) were measured three times weekly and the relationship between plasma steady-state levels and clinical outcome was examined. Steady-state levels ranged from 50 to 1,050 ng/ml. There was a statistically and clinically significant relationship between plasma levels and response. The relationship existed across the entire sample, and was accentuated when the bipolar and unipolar nondelusional populations were examined. Because a strong relationship between sex and outcome was observed, the unipolar nondelusional patients were stratified by sex and a significant relationship still persisted. Only the unipolar delusional patients failed to demonstrate an association between blood level and clinical response.
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Cites
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Weissman, M. M. (1977) · Archives of General Psychiatry · doi:10.1001/archpsyc.1977.01770130100011 · Cited by 1,840
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PLASMA CONCENTRATION OF AMITRIPTYLINE AND CLINICAL RESPONSE
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Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017
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Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism
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Depression in Women: Implications for Health Care Research
Weissman, M. M., & Olfson, M. (1995) · Science · doi:10.1126/science.7638596 · Cited by 525
The pharmacological treatment of delusional depression
(1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.4.430 · Cited by 357
Metadata
- Authors
- Glassman, A. H.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1977-02-01
- Volume
- 34
- Issue
- 2
- Pages
- 197
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2122656874
- Cited by
- 320
- References
- 16
- FWCI
- 27.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Glassman, A. H. (1977). Clinical Implications of Imipramine Plasma Levels for Depressive Illness. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1977.01770140087010
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
