Effects of a Dopamine Agonist Piribedil in Depressed Patients: Relationship of Pretreatment Homovanillic Acid to Antidepressant Response

Post, Robert M.

doi:10.1001/archpsyc.1978.01770290091008

Cited by 168Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

Effects of a Dopamine Agonist Piribedil in Depressed Patients: Relationship of Pretreatment Homovanillic Acid to Antidepressant Response

Post, Robert M.·1978·Archives of General Psychiatry

DOI 10.1001/archpsyc.1978.01770290091008

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Abstract

Piribedil, a compound that stimulates dopamine receptors in a relatively specific fashion, was administered to 11 hospitalized depressed patients. The dopamine agonist significantly decreased rapid eye movement (REM) sleep and percent REM sleep and increased REM latency. Piribedil decreased the probenecid-induced accumulation of the dopamine metabolite homovanillic acid (HVA) in CSF. A range of mild to moderate antidepressant effects was noted; one patient worsened and one developed recurrent manic episodes. The degree of improvement in depression was negatively correlated with pretreatment values of HVA in CSF (r = -.66, P less than .05). These data suggest that the heterogeneity of clinical response may be related to biological differences in depressed patients and that those with low initial dopaminergic function respond best to increased dopamine receptor stimulation.

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Pramipexole, piribedil, tolcapone, and amisulpride are effective in the treatment of MDD.
“Other examples of DA agents effective in the treatment of MDD include the selective D2/D3 receptor agonists pramipexole [292] and piribedil [293] the catechol-O-methyltransferase inhibitor tolcapone, [294], and the preferential presynaptic DA antagonist amisulpride, [295].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [293]

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Authors: Post, R. M.
Corresponding author: Post, Robert M.
ORCID: Post, Robert M.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 1978-05-01
Volume: 35
Issue: 5
Pages: 609
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.1978.01770290091008
OpenAlex: W1981234468
Cited by: 168
References: 65
Citations by year: 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 4
FWCI: 7.95
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: piribedil, dopamine agonists, depression, REM sleep, REM latency, homovanillic acid, cerebrospinal fluid, probenecid, antidepressant response, manic episodes, dopaminergic activity, individual differences in treatment response
MeSH terms: Adult, Bipolar Disorder, Clinical Trials as Topic, Depression, Double-Blind Method, Female, Homovanillic Acid, Humans, Male, Middle Aged, Phenylacetates, Piperazines, Piribedil, Psychiatric Status Rating Scales, Receptors, Dopamine, Sleep, REM

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Effects of a Dopamine Agonist Piribedil in Depressed Patients: Relationship of Pretreatment Homovanillic Acid to Antidepressant Response

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