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Cited by 320

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy Volunteers: Preliminary Findings

de Montigny, Claude·1989·Archives of General Psychiatry
DOI 10.1001/archpsyc.1989.01810060031006
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Abstract

A total of 31 intravenous injections of the tetrapeptide cholecystokinin (30-33) were carried out in ten healthy subjects. In seven subjects, cholecystokinin-4 provoked a short-lasting (one to four minutes) panic-like attack (an intense unexplainable fear) at doses between 20 and 100 micrograms. In the other three subjects, doses of 80 to 100 micrograms induced severe anxiety, but no panic-like attack. All subjects experienced severe gastrointestinal symptoms. Pretreatment with lorazepam, but not with meprobamate or naloxone, prevented the psychic effects of cholecystokinin-4 in subjects who had experienced a panic-like attack with the same dose of this peptide. Following the peptide injection, levels of plasma free catecholamines, lactate, and glucose were unchanged, whereas levels of plasma cortisol and prolactin were increased. The intravenous injection of the sulfated cholecystokinin octapeptide (26-33) in two subjects (doses of 35 and 40 micrograms, respectively) produced severe gastrointestinal symptoms, but failed to induce any anxiety or panic-like attacks. These preliminary findings suggest that cholecystokinin-4 may have a panic-inducing effect. It remains to be established if this peptide exerts this effect via a direct activation of central cholecystokinin receptors.

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Metadata

Authors
de Montigny, C.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1989-06-01
Volume
46
Issue
6
Pages
511
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1989.01810060031006
OpenAlex
W2091964121
Cited by
320
References
32
FWCI
5.71
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy Volunteers: Preliminary Findings. https://app.cochat.ai/papers/10.1001/archpsyc.1989.01810060031006
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de Montigny, C. (1989). Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy Volunteers: Preliminary Findings. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1989.01810060031006

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