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Cited by 435

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Magnetic Resonance Imaging of the Brain in Schizophrenia: The Pathophysiologic Significance of Structural Abnormalities

Andreasen, Nancy C.·1990·Archives of General Psychiatry

Abstract

In a second large series of schizophrenic patients studied with magnetic resonance imaging at the University of Iowa, Iowa City, earlier findings of decreased frontal, cerebral, and cranial size were not replicated. In this second series, control subjects were selected to be educationally equivalent to the schizophrenic patients, a modification in design that may partially account for the failure to replicate. By means of coronal images, ventricular volume was compared in patients and controls and found to differ to a highly significant degree, with the frontal horns being possibly slightly more enlarged than the rest of the ventricular system. A prominent sex effect was also observed, with most of the increased ventricular size occurring in the male patients. Within the male patients, the thalamus was also observed to be significantly smaller, a finding that could be consistent with periventricular injury. Patients with prominent negative symptoms had significantly larger ventricular size than did those with the mixed or positive subtypes. Because of its superior resolution, magnetic resonance imaging appears to offer a more sensitive index of ventricular enlargement than that provided by computed tomography.

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Crossref · 10.1001/archpsyc.1990.01810130037006

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Metadata

Authors
Andreasen, N. C.
Venue
Archives of General Psychiatry
Published
1990-01-01
Volume
47
Issue
1
Pages
35
ISSN
0003-990X (ISSN-L)
OpenAlex
W2061033236
Cited by
435
References
1
FWCI
31.71
Type
journal article
Language
en
Open access
closed

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