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Cited by 176Schizophrenia research and treatmentNeural and Behavioral Psychology StudiesMental Health and Psychiatry

Volumetric analysis of frontal lobe regions in schizophrenia: relation to cognitive function and symptomatology

Baaré, Wim F.C, Hulshoff Pol, Hilleke E, Hijman, Ron, Th. Mali, Willem P, Viergever, Max A, Kahn, René S·1999·Biological Psychiatry
DOI 10.1016/s0006-3223(98)00266-2
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Abstract

Background The purpose of this study was to examine the structure of dorsolateral, medial, and orbital regions of the frontal lobe in schizophrenia, and to determine whether their volumetric measurements were related to cognitive function and symptomatology.Methods High resolution magnetic resonance imaging scans of the brains of 14 schizophrenic patients and 14 closely matched healthy controls were acquired. Volumes of gray and white matter of the left and right dorsolateral, medial, and orbital prefrontal brain regions were measured. Tests of verbal and visual memory and executive functions were used to assess cognitive function. The SANS and SAPS were used to obtain symptom ratings in patients.Results Data of 13 schizophrenic patients were analyzed. Patients showed a general, though not significant, decrease in volumes of frontal regions as compared to controls. In patients, but not in controls, smaller left and right prefrontal gray matter volumes were significantly correlated with impaired performance on immediate recall in verbal and visual memory and semantic fluency. Furthermore, in patients, smaller total orbitofrontal gray matter volume was significantly correlated with more severe negative symptomatology (rs = -.76, p = .006).Conclusions These findings suggest that in schizophrenia, deficits in verbal and visual memory and semantic fluency and negative symptoms may be related to (subtle) abnormalities in frontal lobe structure.

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  • These alterations contribute to predictive impairments as well as to negative and positive psychotic symptoms.

    “These alterations contribute to predictive impairments as well as to negative and positive psychotic symptoms (Baar ´ e et al., 1999; Gur et al., 2000; Nakamura et al., 2008; Onitsuka et al., 2004; Sun et al., 2009; Wible, 2012).”

    From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Baaré et al., 1999

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Authors
Baaré, W. F. C., Hulshoff Pol, H. E., Hijman, R., Th. Mali, W. P., Viergever, M. A., & Kahn, R. S.
Affiliations
University Medical Center Utrecht (NL)
Corresponding author
Baaré, Wim F.C
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1999-06
Volume
45
Issue
12
Pages
1597-1605
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(98)00266-2
OpenAlex
W2042976875
Cited by
176
References
58
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 2 · 2015: 8 · 2014: 7 · 2013: 5 · 2012: 7
FWCI
5.67
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
schizophrenia, frontal lobe, prefrontal cortex, dorsolateral prefrontal cortex, medial prefrontal cortex, orbitofrontal cortex, gray matter volume, white matter volume, verbal memory, visual memory, semantic fluency, executive function, negative symptoms, cognitive function
MeSH terms
Adolescent, Adult, Cognition Disorders, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Neuropsychological Tests, Schizophrenia, Schizophrenic Psychology, Reproducibility of Results

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