The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Psychological Stress-Induced Modulation of Interleukin 2 Receptor Gene Expression and Interleukin 2 Production in Peripheral Blood Leukocytes
Abstract
We explored the expression of the interleukin 2 receptor (IL-2R) and the synthesis of IL-2R messenger RNA by peripheral blood leukocytes obtained from medical students experiencing examination stress in three independent studies. The peripheral blood leukocytes obtained at low-stress baseline periods had significantly higher percentages of IL-2R-positive cells when compared with cells obtained from the same individuals during examinations. In addition, IL2-R messenger RNA in peripheral blood leukocytes decreased significantly during examination periods in a subset of 13 subjects. In one study, we found an increase in the accumulation of interleukin 2 in cultures of cells showing down regulation of IL-2R expression and IL-2R messenger RNA levels. While there are ample data demonstrating stress-associated decrements in the immune response in humans and animals, these data provide the first evidence that this interaction may be observed at the level of gene expression. The data suggest one mechanism whereby the central nervous system modulates the immune response during psychological stress.
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“The findings revealed that occupational stress significantly impacts mental health, with genetic interactions involving BDNF rs10835210 and TPH2 variants further increasing the risk of mental disorders.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [107]
In the citing paper
“Medical students under examination stress exhibit reduced IL-2R-positive cells and IL-2R messenger RNA in blood leukocytes, suggesting a compromised immune function [21,107,108].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [107]
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Stress hormones and immune function
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Self-citationReview of psychosocial stress and asthma: an integrated biopsychosocial approach
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Metadata
- Authors
- Glaser, R.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Glaser, Ronald
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1990-08-01
- Volume
- 47
- Issue
- 8
- Pages
- 707
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2146218160
- Cited by
- 163
- References
- 47
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh040787-07)
- National Institute of Mental Health (MH18831, T32MH018831, MH 40787, MH-44660, P01MH044660)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- psychological stress, interleukin-2 receptor, interleukin-2, gene expression, mRNA, peripheral blood leukocytes, exam stress, medical students
- MeSH terms
- Adult, Cells, Cultured, Female, Humans, Interleukin-2, Leukocytes, Lymphocyte Activation, Male, RNA, Messenger, Stress, Psychological, Receptors, Interleukin-2, Down-Regulation, Gene Expression
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