Cited by 163Stress Responses and CortisolTryptophan and brain disordersCancer, Stress, Anesthesia, and Immune Response

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Psychological Stress-Induced Modulation of Interleukin 2 Receptor Gene Expression and Interleukin 2 Production in Peripheral Blood Leukocytes

Glaser, Ronald·1990·Archives of General Psychiatry

DOI 10.1001/archpsyc.1990.01810200015002

Open this paper in CoChat — free account

Abstract

We explored the expression of the interleukin 2 receptor (IL-2R) and the synthesis of IL-2R messenger RNA by peripheral blood leukocytes obtained from medical students experiencing examination stress in three independent studies. The peripheral blood leukocytes obtained at low-stress baseline periods had significantly higher percentages of IL-2R-positive cells when compared with cells obtained from the same individuals during examinations. In addition, IL2-R messenger RNA in peripheral blood leukocytes decreased significantly during examination periods in a subset of 13 subjects. In one study, we found an increase in the accumulation of interleukin 2 in cultures of cells showing down regulation of IL-2R expression and IL-2R messenger RNA levels. While there are ample data demonstrating stress-associated decrements in the immune response in humans and animals, these data provide the first evidence that this interaction may be observed at the level of gene expression. The data suggest one mechanism whereby the central nervous system modulates the immune response during psychological stress.

Integrity signals

Registry

Crossref · 10.1001/archpsyc.1990.01810200015002

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Untitled work
(1988) · Cited by 4,111
Albumin standards and the measurement of serum albumin with bromcresol green
Doumas, B. T., Watson, W. A., & Biggs, H. G. (1997) · Clinica Chimica Acta · doi:10.1016/s0009-8981(96)06447-9 · Cited by 2,774
STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS
Yamamoto, K. R. (1985) · Annual Review of Genetics · doi:10.1146/annurev.ge.19.120185.001233 · Cited by 1,850
The Psychology of Physical Symptoms
Pennebaker, J. W. (1982) · Springer eBooks · doi:10.1007/978-1-4613-8196-9 · Cited by 1,789
Turnover of Inositol Phospholipids and Signal Transduction
Nishizuka, Y. (1984) · Science · doi:10.1126/science.6147898 · Cited by 1,614
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987) · Science · doi:10.1126/science.2821621 · Cited by 1,504
Long term culture of tumour-specific cytotoxic T cells
Gillis, S. A., & Smith, K. A. (1977) · Nature · doi:10.1038/268154a0 · Cited by 1,384
A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.
Uchiyama, T., Broder, S., & Waldmann, T. A. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.126.4.1393 · Cited by 1,337
T cell growth factor receptors. Quantitation, specificity, and biological relevance
Robb, R., Munck, A. U., & Smith, K. (1981) · The Journal of Experimental Medicine · doi:10.1084/jem.154.5.1455 · Cited by 1,062
The Interleukin-2 T-Cell System: A New Cell Growth Model
Cantrell, D. A., & Smith, K. A. (1984) · Science · doi:10.1126/science.6427923 · Cited by 914

Show all 47 references

Sorted by citations

Psychological stress and the human immune system: a meta-analytic study of 30 Years of inquiry
Segerstrom, S. C., & Miller, G. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.4.601 · Cited by 3,334
The Relationship of Depression and Stressors to Immunological Assays: A Meta-Analytic Review
Zorrilla, E. P., Luborsky, L., McKay, J. R., Rosenthal, R., Houldin, A., Tax, A., McCorkle, R., Seligman, D. A., & Schmidt, K. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0597 · Cited by 995
Cytokines and the Brain: Implications for Clinical Psychiatry
Kronfol, Z., & Remick, D. G. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.683 · Cited by 784
Stress hormones and immune function
Marketon, J. I. W., & Glaser, R. (2008) · Cellular Immunology · doi:10.1016/j.cellimm.2007.09.006 · Cited by 619
Self-citation
Review of psychosocial stress and asthma: an integrated biopsychosocial approach
Wright, R., Rodriguez, M. S., & Cohen, S. (1998) · Thorax · doi:10.1136/thx.53.12.1066 · Cited by 543
Mucosal Wound Healing Is Impaired by Examination Stress
Marucha, P. T., Kiecolt‐Glaser, J. K., & Favagehi, M. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199805000-00025 · Cited by 492
Normally occurring environmental and behavioral influences on gene activity: From central dogma to probabilistic epigenesis
Gottlieb, G. (1998) · Psychological Review · doi:10.1037/0033-295x.105.4.792-802 · Cited by 489
Stress-induced modulation of the immune response to recombinant hepatitis B vaccine.
Glaser, R., Kiecolt‐Glaser, J. K., Bonneau, R. H., Malarkey, W. B., Kennedy, S., & Hughes, J. (1992) · Psychosomatic Medicine · doi:10.1097/00006842-199201000-00005 · Cited by 354
Self-citation
Omega-3 supplementation lowers inflammation and anxiety in medical students: A randomized controlled trial
Kiecolt-Glaser, J. K., Belury, M. A., Andridge, R., Malarkey, W. B., & Glaser, R. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.07.229 · Cited by 340
Self-citation
Biocultural orchestration of developmental plasticity across levels: the interplay of biology and culture in shaping the mind and behavior across the life span
Li, S.-C. (2003) · Psychological Bulletin · doi:10.1037/0033-2909.129.2.171 · Cited by 287
Social psychophysiology and embodiment
Blascovich, J., & Mendes, W. B. (2010) · Handbook of Social Psychology · doi:10.1002/9780470561119.socpsy001006 · Cited by 274
Genomic counter-stress changes induced by the relaxation response
Dusek, J. A., Otu, H. H., Wohlhueter, A. L., Bhasin, M., Zerbini, L. F., Joseph, M. G., Benson, H., & Libermann, T. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002576 · Cited by 248
What Makes Placebo-Controlled Trials Unethical?
Miller, F. G., & Brody, H. A. (2002) · The American Journal of Bioethics · doi:10.1162/152651602317533523 · Cited by 232
Psychoneuroimmunology: Can psychological interventions modulate immunity?
Kiecolt‐Glaser, J. K., & Glaser, R. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.60.4.569 · Cited by 217
Self-citation
Increases in CSF levels of interleukin-2 in schizophrenia: effects of recurrence of psychosis and medication status
McAllister, C. G., van Kammen, D. P., Rehn, T., Miller, A. L., Gurklis, J. A., Kelley, M. E., Yao, J., & Peters, J. L. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1291 · Cited by 205
A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response
Eng, J. W. ‐., Kokolus, K. M., Reed, C. B., Hylander, B. L., Ma, W. W., & Repasky, E. A. (2014) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-014-1617-9 · Cited by 197
Stress, Personal Relationships, and Immune Function: Health Implications
Kiecolt‐Glaser, J. K. (1999) · Brain Behavior and Immunity · doi:10.1006/brbi.1999.0552 · Cited by 169
Stress-associated immune modulation: relevance to viral infections and chronic fatigue syndrome
Glaser, R., & Kiecolt‐Glaser, J. K. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00160-0 · Cited by 169
Self-citation
Relationships between parenting and adolescent adjustment over time: Genetic and environmental contributions.
Neiderhiser, J. M., Reiss, D., Hetherington, E. M., & Plomin, R. J. (1999) · Developmental Psychology · doi:10.1037//0012-1649.35.3.680 · Cited by 148
Prolonged reduction of salivary immunoglobulin A (sIgA) after a major academic exam
Deinzer, R., Kleineidam, C., Stiller-Winkler, R., Idel, H., & Bachg, D. (2000) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(99)00112-9 · Cited by 145
Chronic fatigue syndrome
Devanur, L. D., & Kerr, J. R. (2006) · Journal of Clinical Virology · doi:10.1016/j.jcv.2006.08.013 · Cited by 144
Cycles of contingency
Theodore, N., & Peck, J. (2004) · Routledge studies in the modern world economy · doi:10.4324/9780203579084.ch2 · Cited by 138
Short-term immunological effects of induced emotion.
Knapp, P. H., Levy, E. M., Giorgi, R. G., Black, P. H., Fox, B. H., & Heeren, T. (1992) · Psychosomatic Medicine · doi:10.1097/00006842-199203000-00002 · Cited by 133
Cytokine production in major depressed patients before and after clomipramine treatment
Weizman, R., Laor, N., Podliszewski, E., Notti, I., Djaldetti, M., & Bessler, H. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91166-5 · Cited by 126
A prospective study of neuroendocrine and immune alterations associated with the stress of an oral academic examination among graduate students
Lacey, K. K., Zaharia, M. D., Griffiths, J., Ravindran, A. V., Merali, Z., & Anisman, H. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00059-1 · Cited by 130
SEARCHING FOR THE BIOLOGICAL PATHWAYS BETWEEN STRESS AND HEALTH
Kelly, S., Hertzman, C., & Daniel, M. (1997) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.18.1.437 · Cited by 123
Adrenergic Blockade Ameliorates Cellular Immune Responses to Mental Stress in Humans
Bachen, E. A., Manuck, S. B., Cohen, S., Muldoon, M. F., Raible, R. J., Herbert, T. B., & Rabin, B. S. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199507000-00008 · Cited by 122
Depression and possible cancer risk due to oxidative DNA damage
Irie, M., Miyata, M., & Kasai, H. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.01.009 · Cited by 112
Neuroplasticity, Psychosocial Genomics, and the Biopsychosocial Paradigm in the 21st Century
Garland, E. L., & Howard, M. O. (2009) · Health & Social Work · doi:10.1093/hsw/34.3.191 · Cited by 111
Hypnosis as a modulator of cellular immune dysregulation during acute stress.
Kiecolt‐Glaser, J. K., Marucha, P. T., Atkinson, C., & Glaser, R. (2001) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.69.4.674 · Cited by 105
Self-citation
Dynamics of Stress-Related Decrease of Salivary Immunoglobulin A (sIgA): Relationship to Symptoms of the Common Cold and Studying Behavior
Deinzer, R., & Schüller, N. (1998) · Behavioral Medicine · doi:10.1080/08964289809596372 · Cited by 105
Influence of perceived psychological stress and distress on antibody response to low dose rDNA hepatitis B vaccine
Jabaaij, L., Grosheide, P. M., Heijtink, R. A., Duivenvoorden, H. J., BALLIEUX, R. E., & Vingerhoets, A. J. J. M. (1993) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(93)90138-6 · Cited by 103
Psychosocial and Immune Effects of Self-Hypnosis Training for Stress Management Throughout the First Semester of Medical School
Whitehouse, W. G., Dinges, D. F., Orne, E. C., Keller, S. E., Bates, B. L., Bauer, N. K., Morahan, P. S., Haupt, B. A., Carlin, M. M., Bloom, P. B., et al. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199605000-00009 · Cited by 100
Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment.
Zhang, L., Pan, J., Chen, W., Jiang, J., & Huang, J. (2020) · PubMed · Cited by 107
Influence of psychological stress on immune-inflammatory variables in normal humans. Part II. Altered serum concentrations of natural anti-inflammatory agents and soluble membrane antigens of monocytes and T lymphocytes
Song, C., Kenis, G., Gastel, A. V., Bosmans, E., Lin, A., Jong, R. D., Neels, H. M., Scharpé, S., Janča, A., Yasukawa, K., et al. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00012-8 · Cited by 86
The Role of Stress in Asthma
VIG, R. S., Forsythe, P., & Vliagoftis, H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1366.023 · Cited by 85
Bioenergy definitions and research guidelines.
Hintz, K. J., Yount, G. L., Kadar, I., SCHWARTZ, G. E. R., Hammerschlag, R., & Lin, S. (2003) · PubMed · Cited by 84
Th1 and Th2 cytokine responses to academic stress
Kang, D.-H., & Fox, C. C. (2001) · Research in Nursing & Health · doi:10.1002/nur.1027 · Cited by 84
Changes in plasma nerve growth factor levels in older adults associated with chronic stress
Hadjiconstantinou, M., McGuire, L. M., Duchemin, A., Laskowski, B. F., Kiecolt‐Glaser, J. K., & Glaser, R. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00278-8 · Cited by 78
Self-citation
The effects of stress and relaxation on thein vitro immune response in man: A meta-analytic study
van Rood, Y. R., Bogaards, M., Goulmy, E., & van Houwelingen, H. C. (1993) · Journal of Behavioral Medicine · doi:10.1007/bf00844891 · Cited by 74
Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases.
Shchaslyvyi, A. Y., Antonenko, S. V., & Telegeev, G. D. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21081077 · Cited by 73
A dual pathway model of daily stressor effects on rheumatoid arthritis
Affleck, G. G., URROWS, S. T., Tennen, H. A., Higgins, P. S., Pav, D., & Aloisi, R. M. (1997) · Annals of Behavioral Medicine · doi:10.1007/bf02883333 · Cited by 74
Altered interleukin-2 production in schizophrenia: Association between clinical state and autoantibody production
Ganguli, R., Brar, J. S., Solomon, W., Chengappa, K. N. R., & Rabin, B. S. (1992) · Psychiatry Research · doi:10.1016/0165-1781(92)90046-6 · Cited by 72
The effect of hypnotic-guided imagery on psychological well-being and immune function in patients with prior breast cancer
Bakke, A. C., Purtzer, M. Z., & Newton, P. F. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00409-9 · Cited by 71
Psychoneuroimmunology: Then and Now
Fleshner, M., & Laudenslager, M. L. (2004) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582304269027 · Cited by 71
Disturbance of Serum Interleukin-2 and Interleukin-8 Levels in Posttraumatic and Non-Posttraumatic Stress Disorder Earthquake Survivors in Northern China
Song, Y., Zhou, D., Guan, Z., & Wang, X. (2007) · Neuroimmunomodulation · doi:10.1159/000112050 · Cited by 69
Depression in caregivers of demented patients is associated with altered immunity: impaired proliferative capacity, increased CD8+, and a decline in lymphocytes with surface signal transduction molecules (CD38+) and a cytotoxicity marker (CD56+ CD8+)
Castle, S., Wilkins, S. S., Heck, E., Tanzy, K., & Fahey, J. L. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb03139.x · Cited by 69
Cytokine Profiles of Stimulated Blood Lymphocytes in Asthmatic and Healthy Adolescents Across the School Year
Kang, D.-H., Coe, C. L., McCarthy, D. O., Jarjour, N. N., KELLY, E. A. B., RODRIGUEZ, R. R., & Busse, W. W. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.481 · Cited by 68
Beneficial effects of metoprolol treatment in congestive heart failure. Reversal of sympathetic-induced alterations of immunologic function.
Maisel, A. (1994) · Circulation · doi:10.1161/01.cir.90.4.1774 · Cited by 65
Abnormalities in serum concentrations of interleukin-2, interferon-α and interferon-γ in schizophrenia not detected
Gattaz, W. F., Dalgalarrondo, P., & Schröder, H. C. (1992) · Schizophrenia Research · doi:10.1016/0920-9964(92)90006-q · Cited by 64
Behavioral coping strategies in response to social stress are associated with distinct neuroendocrine, monoaminergic and immune response profiles in mice
Miguel, Z. D., Vegas, Ó., Garmendia, L., Arregi, A., Beitia, G., & Azpiroz, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.011 · Cited by 62
Membrane Phospholipids and Cytokine Interaction in Schizophrenia
Yao, J. K., & van Kammen, D. P. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)59012-8 · Cited by 58
Regulation of Stress-Induced Immunosuppression in the Context of Neuroendocrine, Cytokine, and Cellular Processes
Balakin, E. I., Yurku, K. A., Ivanov, M., Izotov, A., Игоревна, Н. В., & Pustovoit, V. I. (2025) · Biology · doi:10.3390/biology14010076 · Cited by 61
Stress‐Induced Immune Suppression Role of the Autonomic Nervous Systema
Irwin, M. R. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb49933.x · Cited by 56
Temporal covariation of soluble interleukin‐2 receptor levels, daily stress, and disease activity in rheumatoid arthritis
Harrington, L., Affleck, G. G., URROWS, S. T., Tennen, H. A., Higgins, P. S., Zautra, A., & Hoffman, S. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360209 · Cited by 55
Basal Cell Carcinoma
Fagundes, C. P., Glaser, R., Johnson, S. L., Andridge, R., Yang, E. V., Gregorio, M. P. D., Chen, M., Lambert, D. R., Jewell, S. D., Bechtel, M. A., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1535 · Cited by 52
Self-citation
Laughter Regulates Gene Expression in Patients with Type 2 Diabetes
Hayashi, T., Urayama, O., Kawai, K., Hayashi, K., Iwanaga, S., Ohta, M., Saito, T., & Murakami, K. (2005) · Psychotherapy and Psychosomatics · doi:10.1159/000089228 · Cited by 47
Stress, stress management, and the immune system
Zakowski, S. G., Hall, M. H., & Baum, A. E. (1992) · Applied and Preventive Psychology · doi:10.1016/s0962-1849(05)80130-1 · Cited by 45
Stress and coping: the psychoneuroimmunology of HIV/AIDS
Balbin, E., Ironson, G. H., & Solomon, G. F. (1999) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.1999.0047 · Cited by 44
Circulating Lymphocyte Phenotypic Surface Markers in Anxiety Disorder Patients and Normal Volunteers
Rapaport, M. H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00263-1 · Cited by 43
Integrated Defense System Overlaps as a Disease Model: With Examples for Multiple Chemical Sensitivity
Rowat, S. C. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106s185 · Cited by 42
Cytokine production in obsessive-compulsive disorder
Weizman, R., Laor, N., Barber, Y., Hermesh, H., Notti, I., Djaldetti, M., & Bessler, H. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00520-x · Cited by 42
Envisioning a Future Contemplative Science of Mindfulness: Fruitful Methods and New Content for the Next Wave of Research
Garland, E. L., & Gaylord, S. A. (2009) · Complementary health practice review · doi:10.1177/1533210109333718 · Cited by 50
Phenotypic and Molecular Evidence Suggests That Decrements in Morning and Evening Energy Are Distinct but Related Symptoms
Aouizerat, B. E., Dhruva, A., Paul, S. M., Cooper, B. A., Kober, K. M., & Miaskowski, C. A. (2015) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2015.05.008 · Cited by 41
Neural influence on immune responses: underlying suppositions and basic principles of neural-immune signaling
Felten, D. L. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62152-4 · Cited by 39
Neuropeptide Y Plasma Levels and Immunological Changes during Academic Stress
Guidi, L., Tricerri, A., Vangeli, M., Frasca, D., Errani, A. R., Giovanni, A. D., Antico, L., Menini, E., Sciamanna, V., Magnavita, N., et al. (1999) · Neuropsychobiology · doi:10.1159/000026618 · Cited by 39
Effects of behavioral intervention on plasma cortisol and lymphocytes in breast cancer patients: An exploratory study
Schedlowski, M., Jung, C., Schimanski, G., Tewes, U., & Schmoll, H. (1994) · Psycho-Oncology · doi:10.1002/pon.2960030304 · Cited by 38
Psychoneuroimmunology and Aging
Guidi, L., Tricerri, A., Frasca, D., Vangeli, M., Errani, A. R., & Bartoloni, C. (1998) · Gerontology · doi:10.1159/000022021 · Cited by 38
Effect of coping on endocrinoimmune functions in different stress situations
Koh, K. B., Choe, E., Song, J. E., & Lee, E. H. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2005.04.008 · Cited by 37
Counter-stress effects of relaxation on proinflammatory and anti-inflammatory cytokines
Koh, K. B., Lee, Y., Beyn, K. M., Chu, S. H., & Kim, D. M. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.06.009 · Cited by 36
Hepatic and portal vein-thrombosis.
Boughton, B. J. (1991) · BMJ · doi:10.1136/bmj.302.6770.192 · Cited by 35
T-cell subsets in acute psychotic schizophrenic patients
Achiron, A., Noy, S., Pras, E., Lereya, J., Hermesh, H., & Laor, N. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91163-0 · Cited by 33
Gender and asthma
Fuhlbrigge, A. L., Jackson, B., & Wright, R. J. (2002) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00022-x · Cited by 32
Soluble Interleukin‐2 Receptors Increase During the Active Periods in Cluster Headache
Empl, M., Förderreuther, S., Schwarz, M., Müller, N., & Straube, A. M. (2003) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2003.03011.x · Cited by 31
Increased soluble interleukin 2 receptor levels in schizophrenia
Gaughran, F., O'Neill, E., Cole, M., Collins, K., Daly, R. J., & Shanahan, F. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00099-6 · Cited by 31
Enhancing Human Cognitive Capital by Harnessing the Brain’s Inherent Neuroplasticity
Chapman, S. B., Cook, L. G., Vas, A., & Robertson, I. H. (2019) · Oxford University Press eBooks · doi:10.1093/oso/9780190455132.003.0012 · Cited by 30
Alterations in specific antibody production due to rank and social instability
Cunnick, J. E., Cohen, S., Rabin, B. S., Carpenter, A. B., Manuck, S. B., & Kaplan, J. R. (1991) · Brain Behavior and Immunity · doi:10.1016/0889-1591(91)90031-5 · Cited by 30
Alternative modalities for asthma that reduce stress and modify mood states: evidence for underlying psychobiologic mechanisms
Wright, R. J. (2004) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61483-4 · Cited by 29
The glucocorticoid sensitivity of lymphocytes changes according to the activity of the hypothalamic-pituitary-adrenocortical system
Sauer, J., Polack, E., Wikinski, S., Holsboer, F., Stalla, G. K., & ARZT, E. S. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)00058-i · Cited by 29
Alterations in lymphocyte subsets and pituitary-adrenal gland-related hormones during fasting
Komaki, G., Kanazawa, F., Sogawa, H., Mine, K., Tamai, H., Okamura, S., & Kubo, C. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.1.147 · Cited by 29
Neuropsychiatric Aspects of Cytokines Research: An Overview
Malek-Ahmadi, P. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00056-9 · Cited by 25
Quantitative association between altered plasma esterified omega-6 fatty acid proportions and psychological stress
Williams, L. L., Kiecolt‐Glaser, J. K., Horrocks, L. A., Hillhouse, J. T., & Glaser, R. (1992) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(92)90155-c · Cited by 24
Self-citation
Stre� und Immunsystem
Schedlowski, M., & Schmidt, R. E. (1996) · Die Naturwissenschaften · doi:10.1007/bf01143326 · Cited by 23
The impact of psychological stress on the efficacy of anti-viral adoptive immunotherapy in an immunocompromised host
Bonneau, R. H., Brehm, M. A., & Kern, A. M. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00079-9 · Cited by 23
Immune consequences of stroke and cerebral palsy in adults
Rogers, S. L., Coe, C. L., & Karaszewski, J. W. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00157-x · Cited by 22
Stress and coping in the context of psychoneuroimmunology: A holistic framework for nursing practice and research
McCain, N. L., & Smith, J. C. (1994) · Archives of Psychiatric Nursing · doi:10.1016/0883-9417(94)90063-9 · Cited by 22
Stress and Immunity in Humans: Modifying Variables
HALL, N. R. S., Anderson, J. A., & O’Grady, M. P. (1994) · Elsevier eBooks · doi:10.1016/b978-0-12-285960-1.50012-5 · Cited by 20
Individuals and populations: How biology's theory and data have interfered with the integration of development and evolution
Moore, D. S. (2007) · New Ideas in Psychology · doi:10.1016/j.newideapsych.2007.07.009 · Cited by 20
Natural and Cellular Immune Responses in Flinders Sensitive and Resistant Line Rats
Friedman, E. M. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00235-6 · Cited by 18
Detection of salivary interleukin-2 in recurrent aphthous stomatitis
Kalpana, R., Thubashini, M., & Sivapathasundharam, B. (2014) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/0973-029x.151313 · Cited by 17
Herbal Oil Supplement With Hot-Nature Diet for Multiple Sclerosis
Rezapour-Firouzi, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805298-3.00024-4 · Cited by 17
Gene Expression, Neurogenesis, and Healing: Psychosocial Genomics of Therapeutic Hypnosis
Rossi, E. L. (2003) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2003.10403526 · Cited by 16
Effects of mental stressors on mitogen induced lymphocyte responses in the laboratory
Stone, A. A., Valdimarsdottir, H. B., Katkin, E. S., Burns, J. W., Cox, D. S., Lee, S., Fine, J., Ingle, D., & Bovbjerg, D. H. (1993) · Psychology and Health · doi:10.1080/08870449308401921 · Cited by 15
Neuroendocrine–Immune Interactions: Implications for Health and Behavior
Pace, T. W. W., Raison, C. L., & Miller, A. H. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00083-8 · Cited by 15
Effects of cognitive behavioral treatment on physical health status in patients with panic disorder
Schmidt, N. B., McCreary, B. T., Trakowski, J. H., Santiago, H. T., Woolaway-Bickel, K., & Ialongo, N. S. (2003) · Behavior Therapy · doi:10.1016/s0005-7894(03)80021-7 · Cited by 14
Psychological Stress Increases Human T Cell Apoptosis in vitro
Sakami, S., Nakata, A., Yamamura, T., & Kawamura, N. (2002) · NeuroImmunoModulation · doi:10.1159/000068326 · Cited by 14
In Search of a Deep Psychobiology of Hypnosis: Visionary Hypotheses for a New Millennium
Rossi, E. L. (2000) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2000.10734360 · Cited by 14
Psychiatry in the allergy clinic: the nature and management of patients with non‐allergic symptoms
Howard, L. M., & Wessely, S. C. (1995) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1995.tb01087.x · Cited by 14
Stress: another chimera.
Wilkinson, G. (1991) · BMJ · doi:10.1136/bmj.302.6770.191 · Cited by 14
Psychoneuroimmunology: validation of the biopsychosocial model
Trilling, J. S. (2000) · Family Practice · doi:10.1093/fampra/17.1.90 · Cited by 13

Authors: Glaser, R.
Affiliations: The Ohio State University (US)
Corresponding author: Glaser, Ronald
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 1990-08-01
Volume: 47
Issue: 8
Pages: 707
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.1990.01810200015002
OpenAlex: W2146218160
Cited by: 163
References: 47
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
FWCI: 4.97
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01mh040787-07)
National Institute of Mental Health (MH18831, T32MH018831, MH 40787, MH-44660, P01MH044660)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Keywords: psychological stress, interleukin-2 receptor, interleukin-2, gene expression, mRNA, peripheral blood leukocytes, exam stress, medical students
MeSH terms: Adult, Cells, Cultured, Female, Humans, Interleukin-2, Leukocytes, Lymphocyte Activation, Male, RNA, Messenger, Stress, Psychological, Receptors, Interleukin-2, Down-Regulation, Gene Expression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Psychological Stress-Induced Modulation of Interleukin 2 Receptor Gene Expression and Interleukin 2 Production in Peripheral Blood Leukocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks