The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Clonidine Treatment of Gilles de la Tourette's Syndrome
Abstract
The safety and effectiveness of clonidine hydrochloride (3 to 5 micrograms/kg per day) were evaluated in 47 subjects with Gilles de la Tourette's syndrome, aged 7 to 48 years. Twenty-four subjects were randomly assigned to clonidine treatment and 23 to placebo. Forty subjects (21 given clonidine and 19 placebo) successfully completed the 12-week, double-blind clinical trial. Clinical ratings of tic severity improved for both groups. The magnitude of response was greater in the group receiving clonidine. Clinician-rated measures of motor tic severity, the degree to which the tics are "noticeable to others," motor tic counts from videotaped interviews, and parent-rated measures of impulsivity and hyperactivity were the most responsive to clonidine treatment. These results indicate that clonidine is more effective than placebo in reducing some of the tic and other behavioral symptoms associated with Gilles de la Tourette's syndrome.
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Citations
Cites
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The Global Assessment Scale: A Procedure for Measuring Overall Severity of Psychiatric Disturbance
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Self-citationThe Leyton Obsessional Inventory
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Cited by
Tourette syndrome, associated conditions and the complexities of treatment
Robertson, M. M. (2000) · Brain · doi:10.1093/brain/123.3.425 · Cited by 704
Leckman, J. F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11526-1 · Cited by 685
Self-citationScahill, L., Chappell, P. B., Kim, Y. S., Schultz, R. T., Katsovich, L., Shepherd, E., Arnsten, A. F. T., Cohen, D. J., & Leckman, J. F. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1067 · Cited by 588
Self-citationTreatment of ADHD in children with tics: A randomized controlled trial
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Metadata
- Authors
- Leckman, J. F.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1991-04-01
- Volume
- 48
- Issue
- 4
- Pages
- 324
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2015540486
- Cited by
- 335
- References
- 30
- FWCI
- 11.35
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
