European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment
Open accessAbstract
To develop a European guideline on pharmacologic treatment of Tourette syndrome (TS) the available literature was thoroughly screened and extensively discussed by a working group of the European Society for the Study of Tourette syndrome (ESSTS). Although there are many more studies on pharmacotherapy of TS than on behavioral treatment options, only a limited number of studies meets rigorous quality criteria. Therefore, we have devised a two-stage approach. First, we present the highest level of evidence by reporting the findings of existing Cochrane reviews in this field. Subsequently, we provide the first comprehensive overview of all reports on pharmacological treatment options for TS through a MEDLINE, PubMed, and EMBASE search for all studies that document the effect of pharmacological treatment of TS and other tic disorders between 1970 and November 2010. We present a summary of the current consensus on pharmacological treatment options for TS in Europe to guide the clinician in daily practice. This summary is, however, rather a status quo of a clinically helpful but merely low evidence guideline, mainly driven by expert experience and opinion, since rigorous experimental studies are scarce.
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Administration of dopamine antagonists such as risperidone and haloperidol is effective in suppressing tics in most TS patients.
“Several clinical trials have shown that administration of dopamine antagonists, such as risperidone and haloperidol, are effective in suppressing tics in most patients (Bloch et al., 2011; Roessner et al., 2011).”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Roessner et al., 2011
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Research works printed but not linked: 2
- [13]Bastiampillai T Dhillon R Mohindra R Exacerbation of tics secondary to clozapine therapy Aust N Z J Psychiatry 2008 42 1068 1070 19034993
- [30]Bruun RD Budman CL Risperidone as a treatment for Tourette’s syndrome J Clin Psychiatry 1996 57 29 31 8543544
Cited by
Sorted by citations
The brain basis of emotion: a meta-analytic review
Lindquist, K. A., Wager, T. D., Kober, H., Bliss-Moreau, E., & Barrett, L. F. (2012) · Behavioral and Brain Sciences · doi:10.1017/s0140525x11000446 · Cited by 2,320 · see citing works
Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan
Franke, B., Michelini, G., Asherson, P., Banaschewski, T., Bilbow, A., Buitelaar, J. K., Cormand, B., Faraone, S. V., Ginsberg, Y., Haavik, J., et al. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.08.001 · Cited by 643 · see citing works
Cortese, S., Holtmann, M., Banaschewski, T., Buitelaar, J., Coghill, D., Danckaerts, M., Dittmann, R. W., Graham, J., Taylor, E., Sergeant, J., et al. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12036 · Cited by 336 · see citing works
Neuromodulation in Tourette syndrome: dopamine and beyond
Buse, J., Schoenefeld, K., Münchau, A., & Roessner, V. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.10.004 · Cited by 185 · see citing works
Self-citationResponse Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders
van Velzen, L. S., Vriend, C., de Wit, S. J., & van den Heuvel, O. A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00419 · Cited by 159 · see citing works
Ganos, C., & Martino, D. (2015) · Neurologic Clinics · doi:10.1016/j.ncl.2014.09.008 · Cited by 119 · see citing works
Tourette Syndrome and comorbid ADHD: Current pharmacological treatment options
Rizzo, R., Gulisano, M., Calì, P. V., & Curatolo, P. (2013) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2013.01.005 · Cited by 76 · see citing works
Self-citationBehavioural treatment of tics: habit reversal and exposure with response prevention
van de Griendt, J. M. T. M., Verdellen, C. W. J., van Dijk, M. K., & Verbraak, M. J. P. M. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.10.007 · Cited by 75 · see citing works
- Authors
- the ESSTS Guidelines Group, Roessner, V., Plessen, K. J., Rothenberger, A., Ludolph, A. G., Rizzo, R., Skov, L., Strand, G., Stern, J. S., Termine, C., & Hoekstra, P. J.
- Affiliations
- University of Copenhagen (DK)
- Universität Ulm (DE)
- University of Catania (IT)
- Glostrup Hospital (DK)
- Oslo University Hospital (NO)
- St George's Hospital (GB)
- University of Insubria (IT)
- University Medical Center Groningen (NL)
- Corresponding author
- Roessner, Veit
- ORCID
- Venue
- European Child & Adolescent Psychiatry
- Published
- 2011-03-29
- Volume
- 20
- Issue
- 4
- Pages
- 173-196
- ISSN
- 1018-8827 (ISSN-L)
- 1435-165X
- PMC
- PMC3065650
- OpenAlex
- W2171208117
- Cited by
- 461
- References
- 305
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 17 · 2023: 15 · 2022: 27 · 2021: 34 · 2020: 51 · 2019: 35 · 2018: 43 · 2017: 33 · 2016: 44 · 2015: 23 · 2014: 30 · 2013: 44 · 2012: 29
- FWCI
- 38.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- European Child & Adolescent Psychiatry (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by-nc)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- HAL (submittedVersion, other-oa)
- IRIS (submittedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion, cc-by-nc)
- UCL Discovery (University College London) (submittedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- IrInSubria (University of Insubria) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- GRO (submittedVersion, cc-by)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Eli Lilly and Company
- Lundbeckfonden
- H. Lundbeck A/S
- Cilag
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Clinical Psychology › Stuttering Research and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- Tourette syndrome, tic disorders, pharmacotherapy, evidence-based medicine, expert consensus
- MeSH terms
- Europe, Tourette Syndrome, Humans, Tic Disorders, Antipsychotic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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