Cited by 199Treatment of Major DepressionBipolar Disorder and TreatmentMental Health Treatment and Access

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Recovery From Major Depression: A 10-Year Prospective Follow-up Across Multiple Episodes

Solomon, David A.·1997·Archives of General Psychiatry

DOI 10.1001/archpsyc.1997.01830230033005

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Abstract

BACKGROUND: Major depressive disorder is often marked by repeated episodes of depression. We describe recovery from major depression across multiple mood episodes in patients with unipolar major depression at intake and examine the association of sociodemographic and clinical variables with duration of illness. METHODS: A cohort of 258 subjects treated for unipolar major depressive disorder was followed up prospectively for 10 years as part of the Collaborative Depression Study, a multicenter naturalistic study of the mood disorders. Diagnoses were made according to the Research Diagnostic Criteria, and the course of illness was assessed with the Longitudinal Interval Follow-up Evaluation. Survival analyses were used to calculate the duration of illness for the first 5 recurrent mood episodes after recovery from the index episode. RESULTS: Diagnosis remained unipolar major depressive disorder for 235 subjects (91%). The median duration of illness was 22 weeks for the first recurrent mood episode, 20 weeks for the second, 21 weeks for the third, and 19 weeks for the fourth and fifth recurrent mood episodes; the 95% confidence intervals were highly consistent. From one episode to the next, the proportion of subjects who recovered by any one time point was similar. For subjects with 2 or more recoveries, the consistency of duration of illness from one recovery to the next was low to moderate. None of the sociodemographic or clinical variables consistently predicted duration of illness. CONCLUSION: In this sample of patients treated at tertiary care centers for major depressive disorder, the duration of recurrent mood episodes was relatively uniform and averaged approximately 20 weeks.

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Authors: Solomon, D. A.
Affiliations: Brown University (US)
Corresponding author: Solomon, David A.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 1997-11-01
Volume: 54
Issue: 11
Pages: 1001
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.1997.01830230033005
OpenAlex: W2040925948
Cited by: 199
References: 22
Citations by year: 2025: 3 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 8 · 2017: 3 · 2016: 12 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 6
FWCI: 5.35
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01MH025478)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: major depressive disorder, recovery from depression, disease duration, clinical course, sociodemographic predictors, clinical predictors
MeSH terms: Adult, Combined Modality Therapy, Depressive Disorder, Female, Follow-Up Studies, Humans, Imipramine, Male, Prospective Studies, Psychiatric Status Rating Scales, Psychotherapy, Recurrence, Severity of Illness Index, Social Class, Survival Analysis, Marital Status

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Recovery From Major Depression: A 10-Year Prospective Follow-up Across Multiple Episodes

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