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Cited by 6Treatment of Major DepressionMental Health Treatment and AccessBipolar Disorder and Treatment

Predictors of recurrence in a sample of 508 outpatients with major depressive disorder

Serafini, Gianluca, Santi, Francesca, Gonda, Xenia, Aguglia, Andrea, Fiorillo, Andrea, Pompili, Maurizio, Carvalho, André F., Amore, Mario·2019·Journal of Psychiatric Research
DOI 10.1016/j.jpsychires.2019.04.015
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Abstract

Objective Specific predictors of relapse/recurrence in major depressive disorder (MDD) have been identified but evidence across studies are inconsistent. This study aimed to identify the most relevant socio-demographic/clinical predictors of MDD recurrence in a sample of 508 outpatients.Methods This naturalistic cohort study included 508 currently euthymic MDD patients (mean age = 54.1 ± 16.2) of which 53.9% had a single and 46.1% recurrent depressive episodes. A detailed data collection was performed and illness histories were retraced through clinical files and lifetime computerized medical records.Results Compared to patients with single episode, MDD patients with recurrent episodes significantly differ regarding current age, gender, working status, positive history of psychiatric disorders in family, first-lifetime illness episode characteristics, first-episode and current psychotic symptoms, current melancholic features and seasonality, age at first treatment, duration of untreated illness, and comorbid cardiovascular/endocrinological conditions. However, after multivariate analyses controlling for current age, gender, educational level, working status differences, psychiatric conditions in family, and age of illness episode, recurrence was associated with older age (p ≤ .001), younger age at first treatment (p ≤ .005), being treated with previous psychoactive treatments (p .001), and longer duration of untreated illness (p .001).Conclusions The variables associated with MDD recurrence identified in the current study may aid in the stratification of patients who could benefit from more intensive maintenance treatments for MDD. However, clinicians should rapidly identify cases that are not likely to recur in order to avoid unnecessary treatments which are commonly considered as the standard of care.

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  • Results of studies on sociodemographic factors (age, gender, socioeconomic status, marital status) as risk factors for recurrence have been inconsistent.

    “Many studies showed that sociodemographic factors such as younger age, women, and those who have never been married were at higher risk of recurrence [7, 11–15]; however, results of other studies on these risk factors have been inconsistent.”

    From Predictors of recurrence of major depressive disorder (2020) · cites this paper as [15]

  • Some other studies found that age at onset and gender predict recurrence.

    “This is contrary to what some other studies have found [7, 11–15].”

    From Predictors of recurrence of major depressive disorder (2020) · cites this paper as [15]

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Authors
Serafini, G., Santi, F., Gonda, X., Aguglia, A., Fiorillo, A., Pompili, M., Carvalho, A. F., & Amore, M.
Affiliations
  • Ospedale Policlinico San Martino (IT)
  • University of Campania "Luigi Vanvitelli" (IT)
  • Azienda Ospedaliera Sant'Andrea (IT)
Corresponding author
Serafini, Gianluca
ORCID
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2019-07
Volume
114
Pages
80-87
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/j.jpsychires.2019.04.015
OpenAlex
W2937049412
Cited by
6
References
71
Citations by year
2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1
FWCI
0.46
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
  • Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
Magyar Tudományos Akadémia
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
major depressive disorder, depression recurrence, predictors of relapse, outpatients, duration of untreated illness, endogenous depression, seasonal affective disorder, family history of mental illness, maintenance therapy, risk stratification
MeSH terms
Major Depressive Disorder, Humans, Male, Middle Aged, Outpatients, Recurrence, Risk Factors, Socioeconomic Factors

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