The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Folate, Vitamin B12, Homocysteine, and the MTHFR 677C→T Polymorphism in Anxiety and Depression: The Hordaland Homocysteine Study
Abstract
BACKGROUND: An association between depression and folate status has been demonstrated in clinical studies, whereas data are sparse on the relationship between depression and other components of 1-carbon metabolism such as vitamin B12, homocysteine, and the methylenetetrahydrofolate reductase 677C-->T polymorphism. The relationship between anxiety and these components is less well known. This study examined the associations between folate, total homocysteine, vitamin B12, and the methylenetetrahydrofolate reductase 677C-->T polymorphism, and anxiety and depression in a large population-based study. METHODS: Anxiety and depression, measured by the Hospital Anxiety and Depression Scale, were assessed in 5948 subjects aged 46 to 49 years (mean, 47.4 years) and 70 to 74 years (mean, 71.9 years) from the Hordaland Homocysteine Study cohort. By means of logistic regression models, anxiety and depression scores were examined in relation to the factors listed above. RESULTS: Overall, hyperhomocysteinemia (plasma total homocysteine level > or =15.0 micro mol/L [> or =2.02 mg/dL]) (odds ratio, 1.90; 95% confidence interval, 1.11-3.25) and T/T methylenetetrahydrofolate reductase genotype (odds ratio, 1.69; 95% confidence interval, 1.09-2.62), but not low plasma folate or vitamin B12 levels, were significantly related to depression without comorbid anxiety disorder. Plasma folate level was inversely associated with depression only in the subgroup of middle-aged women. None of the investigated parameters showed a significant relationship to anxiety. CONCLUSION: Our results provide further evidence of a role of impaired 1-carbon metabolism in depression.
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Citations
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
The validity of the Hospital Anxiety and Depression Scale
Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00296-3 · Cited by 9,779
Self-citationGlobal mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · cited 1×
“Both anxiety and depression are common symptoms or disorders with a major impact on public health.(9,10) Although a possible role of nutritional factors in the pathogenesis of neuropsychiatric disorders has long been debated,(11,12) clinical studies have shown an inverse relationship between folate status and depressi…”
BackgroundHomocysteine and Cardiovascular Disease
Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180
Self-citationThe economic burden of anxiety disorders in the 1990s
Greenberg, P. E., Sisitsky, T., Kessler, R. C., Finkelstein, S. N., Berndt, E. R., Davidson, J. R. T., Ballenger, J. C., & Fyer, A. J. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n0702 · Cited by 1,242 · cited 1×
“Both anxiety and depression are common symptoms or disorders with a major impact on public health.(9,10) Although a possible role of nutritional factors in the pathogenesis of neuropsychiatric disorders has long been debated,(11,12) clinical studies have shown an inverse relationship between folate status and depressi…”
BackgroundSartorius, N., Üstün, T. B., Lecrubier, Y., & Wittchen, H.-U. (1996) · British Journal of Psychiatry · doi:10.1192/s0007125000298395 · Cited by 541
Vitamin B12, Folate, and Homocysteine in Depression: The Rotterdam Study
Tiemeier, H., van Tuijl, H. R., Hofman, A., Meijer, J., Kiliaan, A. J., & Breteler, M. M. B. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.12.2099 · Cited by 408 · cited 1×
“While some studies have demonstrated a positive relationship between depression and plasma tHcy levels(35) or the MTHFR 677C→T polymorphism,(36) such relationships have not been confirmed in other studies.(14,32,34,37) ORIGINAL ARTICLE”
ResultEnhancement of recovery from psychiatric illness by methylfolate
Godfrey, P. S. A., Toone, B. K., Bottiglien, T., Laundy, M., Reynolds, E. H., Carney, M. W. P., Flynn, T. G., & Chanarin, I. (1990) · The Lancet · doi:10.1016/0140-6736(90)91942-4 · Cited by 389
Coppen, A., & Bailey, J. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00153-1 · Cited by 337
Folate, vitamin B12, and homocysteine in major depressive disorder
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.3.426 · Cited by 287 · cited 2×
“While some studies have demonstrated a positive relationship between depression and plasma tHcy levels(35) or the MTHFR 677C→T polymorphism,(36) such relationships have not been confirmed in other studies.(14,32,34,37) ORIGINAL ARTICLE”
Result
Cited by
Homocysteine and folate metabolism in depression
Bottiglieri, T. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.06.021 · Cited by 459
Devlin, A. M., Brain, U., Austin, J., & Oberlander, T. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012201 · Cited by 308
Anxiety in relation to inflammation and coagulation markers, among healthy adults: The ATTICA Study
Pitsavos, C., Panagiotakos, D. B., Papageorgiou, C., Tsetsekou, E., Soldatos, C., & Stefanadis, C. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.06.001 · Cited by 283
Kennedy, D. O., Veasey, R., Watson, A., Dodd, F., Jones, E., Maggini, S., & Haskell, C. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1870-3 · Cited by 159
Whole genome linkage scan of recurrent depressive disorder from the depression network study
McGuffin, P., Knight, J., Breen, G., Brewster, S., Boyd, P. R., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi363 · Cited by 159
Metadata
- Authors
- Bjelland, I., Tell, G. S., Vollset, S. E., Refsum, H., & Ueland, P. M.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2003-06-01
- Volume
- 60
- Issue
- 6
- Pages
- 618
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2031831813
- Cited by
- 345
- References
- 10
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- closed
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