Whole genome linkage scan of recurrent depressive disorder from the depression network study
Open accessAbstract
Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P < 0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.
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In psychiatry, depression is conceptualized as heterogeneous, multifactorial in causation, and believed to arise from cumulative effects of genetics, adverse events in childhood, and ongoing life stressors.
“Moreover, in psychiatry depression is conceptualized as heterogeneous, multifactorial in causation, and it is believed to arise from the cumulative effects [56–58] of genetics [59–62], adverse events in childhood [63–66], and ongoing life stressors [67–70].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [61]
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- Authors
- McGuffin, P., Knight, J., Breen, G., Brewster, S., Boyd, P. R., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M. J., Perry, J., Preisig, M., Reich, T., Rice, J., Rietschel, M., Jones, L., Sham, P., & Farmer, A. E.
- Affiliations
- King's College London (GB)
- GlaxoSmithKline (United Kingdom) (GB)
- Cardiff University (GB)
- Trinity College Dublin (IE)
- Queen Mary University of London (GB)
- University of Bonn (DE)
- Aarhus University (DK)
- Centre Hospitalier Universitaire Vaudois (CH)
- Washington University in St. Louis (US)
- Central Institute of Mental Health (DE)
- University of Birmingham (GB)
- Corresponding author
- McGuffin, Peter
- ORCID
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-10-03
- Volume
- 14
- Issue
- 22
- Pages
- 3337-3345
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2162633534
- Cited by
- 159
- References
- 4
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 1 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 8 · 2013: 9 · 2012: 20
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- reroDoc Digital Library (submittedVersion)
- IRIS (submittedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- Lancaster EPrints (Lancaster University) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- recurrent major depressive disorder, genome-wide linkage analysis, sib-pair analysis, chromosome 1p36, MTHFR, chromosome 12q, chromosome 13q, chromosome 15q, bipolar disorder, panic disorder, schizophrenia, genetic susceptibility
- MeSH terms
- Adolescent, Adult, Alleles, Chromosome Mapping, Depressive Disorder, Female, Gene Frequency, Humans, Genetic Linkage, Lod Score, Male, Recurrence, Genome, Human, Twin Studies as Topic
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