Thyrocardiac Disease and Its Management with Radioactive Iodine I131
Abstract
Hyperthyroidism was treated with I131 in 1,603 cases. These included cases of diffuse toxic goiter and nodular goiter with hyperthyroidism. There were 187 patients with congestive heart failure, 30 with angina pectoris, and 32 with combined angina pectoris and congestive failure. In addition, there were 107 patients with atrial fibrillation but without congestive failure or angina. Radioiodine was the only treatment used for the hyperthyroid state. The cardiac status was strikingly improved in all groups studied. The number of treatments and incidence of myxedema was almost the same for the cardiac and noncardiac patients. The total administered dose averaged 7.0 millicuries for the entire series and 11.5 for the cardiac patients. The recurrence rate was less than 1%. The authors believe that I131is the treatment choice for thyrocardiac disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In one study of patients with thyrotoxic cardiac disease treated with RAI as the sole modality, no clinical worsening in any cardinal symptom of thyrotoxicosis was seen.
“In one study of patients with thyrotoxic cardiac disease treated with RAI as the sole modality, no clinical worsening in any of the cardinal symptoms of thyrotoxicosis was seen (73).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [73]
Cites
RADIOACTIVE ISOTOPES IN CLINICAL PRACTICE
Quimby, E. H., Feitelberg, S., & Silver, S. (1959) · The American Journal of the Medical Sciences · doi:10.1097/00000441-195909000-00014 · Cited by 38 · see citing works
THE TREATMENT OF TOXIC NODULAR GOITER WITH RADIOACTIVE IODINE: 10 YEARS' EXPERIENCE WITH 436 CASES
Eller, M., Silver, S., Yohalem, S. B., & Segal, R. (1960) · Annals of Internal Medicine · doi:10.7326/0003-4819-52-5-976 · Cited by 31 · see citing works
Diagnosis of masked hyperthyroidism in cardiac patients with auricular fibrillation
Bortin, M. M., Silver, S., & Yohalem, S. B. (1951) · The American Journal of Medicine · doi:10.1016/0002-9343(51)90006-x · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938 · see citing works
“In one study of patients with thyrotoxic cardiac disease treated with RAI as the sole modality, no clinical worsening in any of the cardinal symptoms of thyrotoxicosis was seen (73).”
BackgroundThyroid hormone and the cardiovascular system.
Klein, I., & Ojamaa, K. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102153440707 · Cited by 2,300 · see citing works
Klein, I., & Danzi, S. (2007) · Circulation · doi:10.1161/circulationaha.106.678326 · Cited by 1,324 · see citing works
Bahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., Rivkees, S. A., et al. (2011) · Endocrine Practice · doi:10.4158/ep.17.3.456 · Cited by 1,098 · see citing works
The American Thyroid Association and American Association of Clinical Endocrinologists Taskforce on Hyperthyroidism and Other Causes of Thyrotoxicosis, Bahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., et al. (2011) · Thyroid · doi:10.1089/thy.2010.0417 · Cited by 898 · see citing works
Thyroid Function and Mortality in Patients Treated for Hyperthyroidism
Franklyn, J. A. (2005) · JAMA · doi:10.1001/jama.294.1.71 · Cited by 184 · see citing works
Thyroid Hormone and the Cardiovascular System
Danzi, S. E., & Klein, I. L. (2012) · Medical Clinics of North America · doi:10.1016/j.mcna.2012.01.006 · Cited by 172 · see citing works
Klein, I. L., & Ojamaa, K. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70297-8 · Cited by 139 · see citing works
Dahl, P., Danzi, S. E., & Klein, I. L. (2008) · Current Heart Failure Reports · doi:10.1007/s11897-008-0026-9 · Cited by 136 · see citing works
Forfar, J. C., & Caldwell, G. (1985) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(85)80044-x · Cited by 37 · see citing works
The Diagnosis and Management of Hyperthyroidism Consensus - Report of the Korean Thyroid Association
Yi, K. H., Moon, J. H., Kim, I.-J., Bom, H.-S., Lee, J., Chung, W. Y., Chung, J. H., & Shong, Y. K. (2013) · Journal of Korean Thyroid Association · doi:10.11106/jkta.2013.6.1.1 · Cited by 32 · see citing works
Managing thyroid dysfunction in selected special situations
Sabih, D. E., & Inayatullah, M. (2013) · Thyroid Research · doi:10.1186/1756-6614-6-2 · Cited by 10 · see citing works
Zhou, B., Xie, M., Wang, J., Wang, X., Lv, Q., Liu, M., Kong, S., Zhang, P.-Y., & Liu, J. (2017) · Medicine · doi:10.1097/md.0000000000006711 · Cited by 10 · see citing works
Atrial fibrillation in thyrotoxicosis treated with radioiodine
Staffurth, J., Gibberd, M. C., & Hilton, P. J. (1965) · Postgraduate Medical Journal · doi:10.1136/pgmj.41.481.663 · Cited by 10 · see citing works
Tratamento do hipertireoidismo da Doença de Graves
Andrade, V. A., Gross, J. L., & Maia, A. (2001) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302001000600014 · Cited by 12 · see citing works
Thyroid Function and Mortality in Patients Treated for Hyperthyroidism
Mazzaferri, E. L. (2006) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)70354-8 · Cited by 8 · see citing works
The cardiac effect of epinephrine during anaesthesia in hyperthyroid dogs
Israel, J. S., Byles, P. H., & Dobkin, A. B. (1962) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03019139 · Cited by 5 · see citing works
Graves’ Disease and Cardiac Complications
Arslan, A., & Altay, H. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97128 · Cited by 2 · see citing works
Lee, P. K.-Y., Israel, J. S., & Dobkin, A. B. (1964) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03005091 · Cited by 2 · see citing works
Radioiodine therapy for hyperthyroidism
Fard‐Esfahani, P., Beiki, D., Fallahi, B., Fard‐Esfahani, A., Emami-Ardekani, A., Ansari, M., & Eftekhari, M. (2011) · Iranian Journal of Nuclear Medicine
Braithwaite, S. S. (2008) · Elsevier eBooks · doi:10.1016/b978-032304841-5.50063-7
- Authors
- Delit, C.
- Corresponding author
- Delit, Clement
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1961-04-29
- Volume
- 176
- Issue
- 4
- Pages
- 262
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2015941766
- Cited by
- 21
- References
- 3
- Citations by year
- 2021: 1 · 2017: 1 · 2016: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Keywords
- hyperthyroidism, radioactive iodine, iodine-131, Graves' disease, nodular goiter, congestive heart failure, angina pectoris, atrial fibrillation, myxedema, treatment dose, recurrence
- MeSH terms
- Anti-Arrhythmia Agents, Heart Diseases, Humans, Hyperthyroidism, Iodine, Iodine Radioisotopes, Disease Management
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
