Cited by 2,130Mental Health Treatment and AccessTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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The Functioning and Well-being of Depressed Patients: Results From the Medical Outcomes Study

Wells, Kenneth B.·1989·JAMA

DOI 10.1001/jama.1989.03430070062031

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Abstract

We describe the functioning and well-being of patients with depression, relative to patients with chronic medical conditions or no chronic conditions. Data are from 11 242 outpatients in three health care provision systems in three US sites. Patients with either current depressive disorder or depressive symptoms in the absence of disorder tended to have worse physical, social, and role functioning, worse perceived current health, and greater bodily pain than did patients with no chronic conditions. The poor functioning uniquely associated with depressive symptoms, with or without depressive disorder, was comparable with or worse than that uniquely associated with eight major chronic medical conditions. For example, the unique association of days in bed with depressive symptoms was significantly greater than the comparable association with hypertension, diabetes, and arthritis. Depression and chronic medical conditions had unique and additive effects on patient functioning. (JAMA. 1989;262:914-919)

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“For example, the Medical Outcomes Study [ 5 ] reported that depression associated impairment and disability is equal to that attributable to cardiovascular disease, and greater than that due to other chronic physical disorders such as hypertension, diabetes, and arthritis.”
Background
Stress and Depression in Informal Family Caregivers of Patients with Alzheimer’s Disease
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Late-Life Depression: A Narrative Review on Risk Factors and Prevention
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Psychophysiologic Treatment for Patients With Medically Unexplained Symptoms: A Randomized Controlled Trial
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Negative Thinking Mediates the Effect of Self-Esteem on Depressive Symptoms in College Women
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Predicting Outcomes of Primary Care Patients With Major Depression: Development of a Depression Prognosis Index
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Predictors of nonresponse to treatment in primary care patients with dysthymia
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β-Blockers and Depression: The More the Murkier?
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Functional Health and Well-Being in Patients With Severe Atherosclerotic Peripheral Vascular Occlusive Disease
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“Whereas some studies investi- gating subthreshold depression did not explore co-morbidity of anxiety symptoms (Wells et al. 1989; Judd et al. 1994, 1996) or included anxiety symptoms only in multivariate analyses to control for their confounding effect on outcome variables (Olfson et al. 1996),…”
Background
Late-life depression in primary care
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“CONCLUSIONS: This survey identified several perceived needs for future targeted interventions: (1) additional Agency for Health Care Policy and Research guideline exposure for all primary care physicians, ( 2 ) targeted counseling skill intervention for male physicians and medication management for female physicians,…”
BackgroundInfluential
Reliability and validity of a health-related quality of life battery for evaluating outpatient antidepressant treatment
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Authors: Wells, K. B.
Corresponding author: Wells, Kenneth B.
ORCID: Wells, Kenneth B.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1989-08-18
Volume: 262
Issue: 7
Pages: 914
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1989.03430070062031
OpenAlex: W1539382539
Cited by: 2,130
References: 0
Citations by year: 2026: 9 · 2025: 16 · 2024: 18 · 2023: 18 · 2022: 21 · 2021: 39 · 2020: 30 · 2019: 33 · 2018: 31 · 2017: 30 · 2016: 25 · 2015: 44 · 2014: 44 · 2013: 61 · 2012: 49
FWCI: 66.14
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
Funders: National Institute of Mental Health (MH 42229-03S1)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: depression, depressive symptoms, chronic disease, functional status, well-being, physical function, social functioning, role functioning, health perception, bodily pain, outpatients, comorbidities

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The Functioning and Well-being of Depressed Patients: Results From the Medical Outcomes Study

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