Cited by 2,130Mental Health Treatment and AccessTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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The Functioning and Well-being of Depressed Patients: Results From the Medical Outcomes Study

Wells, Kenneth B.·1989·JAMA

DOI 10.1001/jama.1989.03430070062031

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Abstract

We describe the functioning and well-being of patients with depression, relative to patients with chronic medical conditions or no chronic conditions. Data are from 11 242 outpatients in three health care provision systems in three US sites. Patients with either current depressive disorder or depressive symptoms in the absence of disorder tended to have worse physical, social, and role functioning, worse perceived current health, and greater bodily pain than did patients with no chronic conditions. The poor functioning uniquely associated with depressive symptoms, with or without depressive disorder, was comparable with or worse than that uniquely associated with eight major chronic medical conditions. For example, the unique association of days in bed with depressive symptoms was significantly greater than the comparable association with hypertension, diabetes, and arthritis. Depression and chronic medical conditions had unique and additive effects on patient functioning. (JAMA. 1989;262:914-919)

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Method
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Method
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Background
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BackgroundResultSelf-citation
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“Moreover, social functioning is significantly more impaired by MDD than it is by other chronic illness such as hypertension, diabetes and arthritis [29].”
Background
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Corden, M. E., Koucky, E. M., Brenner, C. J., Palac, H., Soren, A., Begale, M. J., Ruo, B., Kaiser, S. M., Duffecy, J., & Mohr, D. C. (2016) · Digital Health · doi:10.1177/2055207616663069 · Cited by 39
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Anxiety, depression, and insomnia
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Paroxetine treatment of sexual disinhibition in dementia
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Healthy Moms, a randomized trial to promote and evaluate weight maintenance among obese pregnant women: Study design and rationale
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“These tools have been used elsewhere to study health status in pregnant populations [51–55].”
Method
The effect of vortioxetine on health-related quality of life in patients with major depressive disorder
Florea, I., Danchenko, N., Brignone, M., Loft, H., Rive, B., & Abetz-Webb, L. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.08.008 · Cited by 35
Predictors of outcome in guided self-help cognitive behavioural therapy for common mental disorders in primary care
Salomonsson, S., Santoft, F., Lindsäter, E., Ejeby, K., Ingvar, M., Öst, L.-G., Lekander, M., Ljótsson, B., & Hedman-Lagerlöf, E. (2020) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2019.1669701 · Cited by 20
“CMDs lead to a considerable decrease in functioning and quality of life (Comer et al., 2011; Wells et al., 1989).”
Background

Authors: Wells, K. B.
Corresponding author: Wells, Kenneth B.
ORCID: Wells, Kenneth B.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1989-08-18
Volume: 262
Issue: 7
Pages: 914
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1989.03430070062031
OpenAlex: W1539382539
Cited by: 2,130
References: 0
Citations by year: 2026: 9 · 2025: 16 · 2024: 18 · 2023: 18 · 2022: 21 · 2021: 39 · 2020: 30 · 2019: 33 · 2018: 31 · 2017: 30 · 2016: 25 · 2015: 44 · 2014: 44 · 2013: 61 · 2012: 49
FWCI: 66.14
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
Funders: National Institute of Mental Health (MH 42229-03S1)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: depression, depressive symptoms, chronic disease, functional status, well-being, physical function, social functioning, role functioning, health perception, bodily pain, outpatients, comorbidities

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The Functioning and Well-being of Depressed Patients: Results From the Medical Outcomes Study

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