Cited by 2,130Mental Health Treatment and AccessTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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The Functioning and Well-being of Depressed Patients: Results From the Medical Outcomes Study

Wells, Kenneth B.·1989·JAMA

DOI 10.1001/jama.1989.03430070062031

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Abstract

We describe the functioning and well-being of patients with depression, relative to patients with chronic medical conditions or no chronic conditions. Data are from 11 242 outpatients in three health care provision systems in three US sites. Patients with either current depressive disorder or depressive symptoms in the absence of disorder tended to have worse physical, social, and role functioning, worse perceived current health, and greater bodily pain than did patients with no chronic conditions. The poor functioning uniquely associated with depressive symptoms, with or without depressive disorder, was comparable with or worse than that uniquely associated with eight major chronic medical conditions. For example, the unique association of days in bed with depressive symptoms was significantly greater than the comparable association with hypertension, diabetes, and arthritis. Depression and chronic medical conditions had unique and additive effects on patient functioning. (JAMA. 1989;262:914-919)

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“The Veterans Health Study (VHS; Kazis et al., 1998) offers a unique opportunity to “benchmark” the effect of PTSD on health status (using the SF-36), as the Medical Outcomes Study (MOS) has done for depression (Hays et al., 1995; Wells et al., 1989a).”
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“Mood and anxiety disorders have been shown to be associated with significant disability (26, 39-40), which can be ameliorated by treatment.”
Background

Authors: Wells, K. B.
Corresponding author: Wells, Kenneth B.
ORCID: Wells, Kenneth B.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1989-08-18
Volume: 262
Issue: 7
Pages: 914
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1989.03430070062031
OpenAlex: W1539382539
Cited by: 2,130
References: 0
Citations by year: 2026: 9 · 2025: 16 · 2024: 18 · 2023: 18 · 2022: 21 · 2021: 39 · 2020: 30 · 2019: 33 · 2018: 31 · 2017: 30 · 2016: 25 · 2015: 44 · 2014: 44 · 2013: 61 · 2012: 49
FWCI: 66.14
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
Funders: National Institute of Mental Health (MH 42229-03S1)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: depression, depressive symptoms, chronic disease, functional status, well-being, physical function, social functioning, role functioning, health perception, bodily pain, outpatients, comorbidities

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The Functioning and Well-being of Depressed Patients: Results From the Medical Outcomes Study

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