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The Functioning and Well-being of Depressed Patients: Results From the Medical Outcomes Study
Abstract
We describe the functioning and well-being of patients with depression, relative to patients with chronic medical conditions or no chronic conditions. Data are from 11 242 outpatients in three health care provision systems in three US sites. Patients with either current depressive disorder or depressive symptoms in the absence of disorder tended to have worse physical, social, and role functioning, worse perceived current health, and greater bodily pain than did patients with no chronic conditions. The poor functioning uniquely associated with depressive symptoms, with or without depressive disorder, was comparable with or worse than that uniquely associated with eight major chronic medical conditions. For example, the unique association of days in bed with depressive symptoms was significantly greater than the comparable association with hypertension, diabetes, and arthritis. Depression and chronic medical conditions had unique and additive effects on patient functioning. (JAMA. 1989;262:914-919)
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“When present alone, depression was found to be as debilitating an illness as a chronic somatic illness [28].”
From Treatment of somatization in primary care (1997) · cites this paper as [28]
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“[49] found that elderly studies have consistently found an association bepatients with significant depressive symptoms had tween depression and work impairment.[73-77] A total healthcare costs 50% higher per year than those study of the impact of chronic conditions on work without symptoms ($US2147 vs $US1461; 1995 im…”
BackgroundAntidepressants for treating depression in dementia
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“Likewise, persons with significant, non-clinical depressive symptoms exhibit substantially poorer performance at work and at home compared to persons with a variety of other ailments (Wells et al., 1989).”
Background
Metadata
- Authors
- Wells, K. B.
- Corresponding author
- Wells, Kenneth B.
- ORCID
- Wells, Kenneth B.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1989-08-18
- Volume
- 262
- Issue
- 7
- Pages
- 914
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1539382539
- Cited by
- 2,130
- References
- 0
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 18 · 2023: 18 · 2022: 21 · 2021: 39 · 2020: 30 · 2019: 33 · 2018: 31 · 2017: 30 · 2016: 25 · 2015: 44 · 2014: 44 · 2013: 61 · 2012: 49
- FWCI
- 66.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- Funders
- National Institute of Mental Health (MH 42229-03S1)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression, depressive symptoms, chronic disease, functional status, well-being, physical function, social functioning, role functioning, health perception, bodily pain, outpatients, comorbidities
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