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Cited by 718Food composition and propertiesDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Effect of a Low–Glycemic Index or a High–Cereal Fiber Diet on Type 2 Diabetes: A Randomized Trial

Jenkins, David J. A., Kendall, Cyril W. C., McKeown-Eyssen, Gail, Josse, Robert G., Silverberg, Jay, Booth, Gillian L., Vidgen, Edward, Josse, Andrea R., Nguyen, Tri H., Corrigan, Sorcha, Banach, Monica S., Ares, Sophie, Mitchell, Sandy, Emam, Azadeh, Augustin, Livia S. A., Parker, Tina L., Leiter, Lawrence A.·2008·JAMA
DOI 10.1001/jama.2008.808
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Abstract

CONTEXT: Clinical trials using antihyperglycemic medications to improve glycemic control have not demonstrated the anticipated cardiovascular benefits. Low-glycemic index diets may improve both glycemic control and cardiovascular risk factors for patients with type 2 diabetes but debate over their effectiveness continues due to trial limitations. OBJECTIVE: To test the effects of low-glycemic index diets on glycemic control and cardiovascular risk factors in patients with type 2 diabetes. DESIGN, SETTING, AND PARTICIPANTS: A randomized, parallel study design at a Canadian university hospital research center of 210 participants with type 2 diabetes treated with antihyperglycemic medications who were recruited by newspaper advertisement and randomly assigned to receive 1 of 2 diet treatments each for 6 months between September 16, 2004, and May 22, 2007. INTERVENTION: High-cereal fiber or low-glycemic index dietary advice. MAIN OUTCOME MEASURES: Absolute change in glycated hemoglobin A(1c) (HbA(1c)), with fasting blood glucose and cardiovascular disease risk factors as secondary measures. RESULTS: In the intention-to-treat analysis, HbA(1c) decreased by -0.18% absolute HbA(1c) units (95% confidence interval [CI], -0.29% to -0.07%) in the high-cereal fiber diet compared with -0.50% absolute HbA(1c) units (95% CI, -0.61% to -0.39%) in the low-glycemic index diet (P < .001). There was also an increase of high-density lipoprotein cholesterol in the low-glycemic index diet by 1.7 mg/dL (95% CI, 0.8-2.6 mg/dL) compared with a decrease of high-density lipoprotein cholesterol by -0.2 mg/dL (95% CI, -0.9 to 0.5 mg/dL) in the high-cereal fiber diet (P = .005). The reduction in dietary glycemic index related positively to the reduction in HbA(1c) concentration (r = 0.35, P < .001) and negatively to the increase in high-density lipoprotein cholesterol (r = -0.19, P = .009). CONCLUSION: In patients with type 2 diabetes, 6-month treatment with a low-glycemic index diet resulted in moderately lower HbA(1c) levels compared with a high-cereal fiber diet. Trial Registration clinicaltrials.gov identifier: NCT00438698.

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Metadata

Authors
Jenkins, D. J. A., Kendall, C. W. C., McKeown-Eyssen, G., Josse, R. G., Silverberg, J., Booth, G. L., Vidgen, E., Josse, A. R., Nguyen, T. H., Corrigan, S., Banach, M. S., Ares, S., Mitchell, S., Emam, A., Augustin, L. S. A., Parker, T. L., & Leiter, L. A.
Affiliations
St. Michael's Hospital (CA)
Corresponding author
Jenkins, David J. A.
ORCID
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2008-12-17
Volume
300
Issue
23
Pages
2742
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.2008.808
OpenAlex
W2035569239
Cited by
718
References
44
Citations by year
2026: 6 · 2025: 19 · 2024: 15 · 2023: 12 · 2022: 68 · 2021: 56 · 2020: 26 · 2019: 12 · 2018: 19 · 2017: 18 · 2016: 154 · 2015: 60 · 2014: 32 · 2013: 85 · 2012: 38
FWCI
30.98
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 2 diabetes, low glycemic index diet, glycemic control, HbA1c, cardiovascular risk factors, HDL cholesterol, dietary intervention, antihyperglycemic medications, fasting blood glucose, cardiovascular disease prevention, lifestyle modification, glycemic index, dietary fiber, intention-to-treat analysis
MeSH terms
Aged, Hypolipidemic Agents, Blood Glucose, Cardiovascular Diseases, Edible Grain, Combined Modality Therapy, Diabetes Mellitus, Type 2, Dietary Carbohydrates, Dietary Fiber, Female, Glycated Hemoglobin, Humans, Male, Middle Aged, Risk Factors, Glycemic Index

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