IMPOSE (IMProving Outcomes after Sepsis)—the effect of a multidisciplinary follow-up service on health-related quality of life in patients postsepsis syndromes—a double-blinded randomised controlled trial: protocol
Open accessAbstract
Introduction: Patients post sepsis syndromes have a poor quality of life and a high rate of recurring illness or mortality. Follow-up clinics have been instituted for patients postgeneral intensive care but evidence is sparse, and there has been no clinic specifically for survivors of sepsis. The aim of this trial is to investigate if targeted screening and appropriate intervention to these patients can result in an improved quality of life (Short Form 36 health survey (SF36V.2)), decreased mortality in the first 12 months, decreased readmission to hospital and/or decreased use of health resources. Methods and analysis: 204 patients postsepsis syndromes will be randomised to one of the two groups. The intervention group will attend an outpatient clinic two monthly for 6 months and receive screening and targeted intervention. The usual care group will remain under the care of their physician. To analyse the results, a baseline comparison will be carried out between each group. Generalised estimating equations will compare the SF36 domain scores between groups and across time points. Mortality will be compared between groups using a Cox proportional hazards (time until death) analysis. Time to first readmission will be compared between groups by a survival analysis. Healthcare costs will be compared between groups using a generalised linear model. Economic (health resource) evaluation will be a within-trial incremental cost utility analysis with a societal perspective. Ethics and dissemination: Ethical approval has been granted by the Royal Brisbane and Women’s Hospital Human Research Ethics Committee (HREC; HREC/13/QRBW/17), The University of Queensland HREC (2013000543), Griffith University (RHS/08/14/HREC) and the Australian Government Department of Health (26/2013). The results of this study will be submitted to peer-reviewed intensive care journals and presented at national and international intensive care and/or rehabilitation conferences. Trial registration number: Australian and New Zealand Clinical Trials Registry ACTRN12613000528752.
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With increased recognition of post-intensive care syndrome in survivors of critical illness and their families, peer support represents a patient-centered approach to improve long-term outcomes.
“With increased recognition of post-intensive care syndrome (PICS) in survivors of critical illness and their families, peer support represents a patient-centered approach to improve long-term outcomes (552, 553).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [552]
The Background describes post-ICU syndrome in survivors and its impact on carers. The Intervention section proposes individualized multidisciplinary follow-up, not peer support; the paper does not support the claim that peer support is an approach to improving long-term outcomes. (LLM, conf=0.87)
Experimental — accuracy not yet measuredMore studies of post-sepsis follow-up programmes are in process.
“More studies of post-sepsis follow-up programmes are in process [641, 642].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [642]
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BackgroundKjær, M. N., Madsen, M. B., Møller, M. H., Egerod, I., & Perner, A. (2019) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.13326 · Cited by 3 · see citing works
Langzeitmorbidität, -letalität und Lebensqualität
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Ding, Z. (2017) · D-Scholarship@Pitt (University of Pittsburgh)
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Inflammation associated with sepsis and correlation with neural and cognitive disorders
Lima, L., Bernardes, N. B., Viana, N. I., Santos, T. G., & Faria, C. B. P. (2023) · Concilium · doi:10.53660/clm-1848-23m53
Principles and Management of Sepsis
Edel, A., Fuest, K. E., & Karlis, G. (2023) · Lessons from the ICU · doi:10.1007/978-3-031-36398-6_1
- Authors
- Paratz, J. D., Kenardy, J., Mitchell, G., Comans, T., Coyer, F., Thomas, P., Singh, S., Luparia, L., & Boots, R. J.
- Affiliations
- Griffith University (AU)
- The University of Queensland (AU)
- Queensland University of Technology (AU)
- Intensive Care Unit, Bundaberg Hospital, Bundaberg, Queensland, Australia
- Corresponding author
- Paratz, Jennifer D
- ORCID
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2014-05
- Volume
- 4
- Issue
- 5
- Pages
- e004966
- ISSN
- 2044-6055 (ISSN-L)
- PMC
- PMC4039866
- OpenAlex
- W2149073353
- Cited by
- 29
- References
- 53
- Citations by year
- 2023: 4 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 5
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMJ Open (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (acceptedVersion, cc-by)
- HighWire Press Open Archive (acceptedVersion)
- Griffith Research Online (submittedVersion, cc-by)
- Funders
- Australian Government
- Griffith University
- University of Queensland
- Queensland Government
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Keywords
- sepsis survivors, health-related quality of life, mortality, hospital readmission, health care costs, sepsis screening, intensive care unit survivors
- MeSH terms
- Aftercare, Double-Blind Method, Follow-Up Studies, Humans, Patient Care Team, Quality of Life, Research Design, Syndrome, Sepsis
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