Structured, proactive care coordination versus usual care for Improving Morbidity during Post-Acute Care Transitions for Sepsis (IMPACTS): a pragmatic, randomized controlled trial
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Abstracts: Background: Hospital mortality for patients with sepsis has recently declined, but sepsis survivors still suffer from significant long-term mortality and morbidity. There are limited data that support effective strategies to address post-discharge management of patients hospitalized with sepsis. Methods: The Improving Morbidity during Post-Acute Care Transitions for Sepsis (IMPACTS) study is a pragmatic, randomized controlled trial at three hospitals within a single healthcare delivery system comparing clinical outcomes between sepsis survivors who receive usual care versus care delivered through the Sepsis Transition and Recovery (STAR) program. The STAR program includes a centrally located nurse navigator using telephone counseling and electronic health record-based support to facilitate best-practice post-sepsis care strategies for patients during hospitalization and the 30 days after hospital discharge, including post-discharge review of medications, evaluation for new impairments or symptoms, monitoring existing comorbidities, and palliative care referral when appropriate. Adults admitted through the Emergency Department with suspected infection (i.e., antibiotics initiated, bacterial cultures drawn) and deemed, by previously developed risk-stratification models, high risk for readmission or death are included. Eligible patients are randomly allocated 1:1 to either Arm 1, usual care or Arm 2, STAR. Planned enrollment is 708 patients during a 6-month period. The primary outcome is the composite of all-cause hospital readmissions and mortality assessed 30 days post discharge. Secondary outcomes include 30- and 90-day hospital readmissions, mortality, emergency department visits, acute care-free days alive, and acute care and total costs. Discussion: This pragmatic evaluation provides the most comprehensive assessment to date of a strategy to improve delivery of recommended post-sepsis care. Trial registration: ClinicalTrials.gov, NCT03865602. Registered retrospectively on 6 March 2019.
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More studies of post-sepsis follow-up programmes are in process.
“More studies of post-sepsis follow-up programmes are in process [641, 642].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [641]
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
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- Authors
- On behalf of Atrium Health ACORN Investigators, Kowalkowski, M., Chou, S.-H., McWilliams, A., Lashley, C., Murphy, S., Rossman, W., Papali, A., Heffner, A., Russo, M., Burke, L., Gibbs, M., & Taylor, S. P.
- Corresponding author
- Kowalkowski, Marc
- ORCID
- Venue
- Trials
- Published
- 2019-11-29
- Volume
- 20
- Issue
- 1
- Pages
- 660-660
- ISSN
- 1745-6215 (ISSN-L)
- PMC
- PMC6884908
- OpenAlex
- W2991626071
- Cited by
- 29
- References
- 66
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 3 · 2018: 1
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Trials (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Emergency Medicine › Hospital Admissions and Outcomes
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- sepsis, post-discharge care, care coordination, nurse navigators, hospital readmission, post-discharge mortality, sepsis survivors, STAR program, telephone counseling, palliative care referral, emergency department visits, health care costs, impact
- MeSH terms
- Aged, Aged, 80 and over, Continuity of Patient Care, Female, Humans, Male, Morbidity, Randomized Controlled Trials as Topic, Sepsis, Pragmatic Clinical Trials as Topic
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