The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial
Open accessAbstract
CONTEXT: Clinical trial results suggest that intracoronary delivery of autologous bone marrow mononuclear cells (BMCs) may improve left ventricular (LV) function when administered within the first week following myocardial infarction (MI). However, because a substantial number of patients may not present for early cell delivery, the efficacy of autologous BMC delivery 2 to 3 weeks post-MI warrants investigation. OBJECTIVE: To determine if intracoronary delivery of autologous BMCs improves global and regional LV function when delivered 2 to 3 weeks following first MI. DESIGN, SETTING, AND PATIENTS: A randomized, double-blind, placebo-controlled trial (LateTIME) of the National Heart, Lung, and Blood Institute-sponsored Cardiovascular Cell Therapy Research Network of 87 patients with significant LV dysfunction (LV ejection fraction [LVEF] ≤45%) following successful primary percutaneous coronary intervention (PCI) between July 8, 2008, and February 28, 2011. INTERVENTIONS: Intracoronary infusion of 150 × 10(6) autologous BMCs (total nucleated cells) or placebo (BMC:placebo, 2:1) was performed within 12 hours of bone marrow aspiration after local automated cell processing. MAIN OUTCOME MEASURES: Changes in global (LVEF) and regional (wall motion) LV function in the infarct and border zone between baseline and 6 months, measured by cardiac magnetic resonance imaging. Secondary end points included changes in LV volumes and infarct size. RESULTS: A total of 87 patients were randomized (mean [SD] age, 57 [11] years; 83% men). Harvesting, processing, and intracoronary delivery of BMCs in this setting was feasible. Change between baseline and 6 months in the BMC group vs placebo for mean LVEF (48.7% to 49.2% vs 45.3% to 48.8%; between-group mean difference, -3.00; 95% CI, -7.05 to 0.95), wall motion in the infarct zone (6.2 to 6.5 mm vs 4.9 to 5.9 mm; between-group mean difference, -0.70; 95% CI, -2.78 to 1.34), and wall motion in the border zone (16.0 to 16.6 mm vs 16.1 to 19.3 mm; between-group mean difference, -2.60; 95% CI, -6.03 to 0.77) were not statistically significant. No significant change in LV volumes and infarct volumes was observed; both groups decreased by a similar amount at 6 months vs baseline. CONCLUSION: Among patients with MI and LV dysfunction following reperfusion with PCI, intracoronary infusion of autologous BMCs vs intracoronary placebo infusion, 2 to 3 weeks after PCI, did not improve global or regional function at 6 months. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00684060.
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Bone marrow cells regenerate infarcted myocardium
Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B., Pickel, J., McKay, R., Nadal-Ginard, B., Bodine, D. M., et al. (2001) · Nature · doi:10.1038/35070587 · Cited by 5,155
Wollert, K. C., Meyer, G. P., Lotz, J., Ringes Lichtenberg, S., Lippolt, P., Breidenbach, C., Fichtner, S., Korte, T., Hornig, B., Messinger, D., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16626-9 · Cited by 2,191
Intracoronary Bone Marrow–Derived Progenitor Cells in Acute Myocardial Infarction
Schächinger, V., Erbs, S., Elsässer, A., Haberbosch, W., Hambrecht, R., Hölschermann, H., Yu, J., Corti, R., Mathey, D. G., Hamm, C. W., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060186 · Cited by 1,890
Hare, J. M., Traverse, J. H., Henry, T. D., Dib, N., Strumpf, R. K., Schulman, S. P., Gerstenblith, G., DeMaria, A. N., Denktas, A. E., Gammon, R. S., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.06.055 · Cited by 1,350
Self-citationIntracoronary Injection of Mononuclear Bone Marrow Cells in Acute Myocardial Infarction
Lunde, K., Solheim, S., Aakhus, S., Arnesen, H., Abdelnoor, M., Egeland, T., Endresen, K., Ilebekk, A., Mangschau, A., Fjeld, J. G., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055706 · Cited by 1,310
Janssens, S., Dubois, C., Bogaert, J., Theunissen, K., Deroose, C., Desmet, W., Kalantzi, M., Herbots, L., Sinnaeve, P., Dens, J., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(05)67861-0 · Cited by 1,294
Askari, A. T., Unzek, S., Popovic, Z. B., Goldman, C. K., Forudi, F., Kiedrowski, M., Rovner, A., Ellis, S. G., Thomas, J. D., DiCorleto, P. E., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14232-8 · Cited by 1,270
Mobilization of Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction
Shintani, S., Murohara, T., Ikeda, H., Ueno, T., Honma, T., Katoh, A., Sasaki, K.-I., Shimada, T., Oike, Y., & Imaizumi, T. (2001) · Circulation · doi:10.1161/hc2301.092122 · Cited by 1,185
Amado, L. C., Saliaris, A. P., Schuleri, K. H., St. John, M., Xie, J.-S., Cattaneo, S., Durand, D. J., Fitton, T., Kuang, J. Q., Stewart, G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504388102 · Cited by 1,073
Adult Bone Marrow–Derived Cells for Cardiac Repair: A Systematic Review and Meta-analysis
Abdel-Latif, A. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.10.989 · Cited by 880
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WRITING COMMITTEE MEMBERS*, O’Gara, P. T., Kushner, F. G., Ascheim, D. D., Casey, D. E., Chung, M. K., de Lemos, J. A., Ettinger, S. M., Fang, J. C., Fesmire, F. M., et al. (2013) · Circulation · doi:10.1161/cir.0b013e3182742cf6 · Cited by 4,725
2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction
O'Gara, P. T., Kushner, F. G., Ascheim, D. D., Casey, D. E., Chung, M. K., de Lemos, J. A., Ettinger, S. M., Fang, J. C., Fesmire, F. M., Franklin, B. A., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.019 · Cited by 2,625
Makkar, R. R., Smith, R. R., Cheng, K., Malliaras, K., Thomson, L. E., Berman, D., Czer, L. S., Marbán, L., Mendizabal, A., Johnston, P. V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60195-0 · Cited by 1,422
Cardiopoietic Stem Cell Therapy in Heart Failure
Bartunek, J., Behfar, A., Dolatabadi, D., Vanderheyden, M., Ostojic, M., Dens, J., El Nakadi, B., Banovic, M., Beleslin, B., Vrolix, M., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.071 · Cited by 493
Gyöngyösi, M., Wojakowski, W., Lemarchand, P., Lunde, K., Tendera, M., Bartunek, J., Marban, E., Assmus, B., Henry, T. D., Traverse, J. H., et al. (2015) · Circulation Research · doi:10.1161/circresaha.116.304346 · Cited by 313
Self-citation
Metadata
- Authors
- Traverse, J. H.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2011-11-16
- Volume
- 306
- Issue
- 19
- Pages
- 2110
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2143815163
- Cited by
- 405
- References
- 28
- FWCI
- 23.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Traverse, J. H. (2011). Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial. JAMA. https://doi.org/10.1001/jama.2011.1670
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