The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial
Open accessAbstract
IMPORTANCE: More than 80% of patients with heart failure with preserved ejection fraction (HFPEF), the most common form of heart failure among older persons, are overweight or obese. Exercise intolerance is the primary symptom of chronic HFPEF and a major determinant of reduced quality of life (QOL). OBJECTIVE: To determine whether caloric restriction (diet) or aerobic exercise training (exercise) improves exercise capacity and QOL in obese older patients with HFPEF. DESIGN, SETTING, AND PARTICIPANTS: Randomized, attention-controlled, 2 × 2 factorial trial conducted from February 2009 through November 2014 in an urban academic medical center. Of 577 initially screened participants, 100 older obese participants (mean [SD]: age, 67 years [5]; body mass index, 39.3 [5.6]) with chronic, stable HFPEF were enrolled (366 excluded by inclusion and exclusion criteria, 31 for other reasons, and 80 declined participation). INTERVENTIONS: Twenty weeks of diet, exercise, or both; attention control consisted of telephone calls every 2 weeks. MAIN OUTCOMES AND MEASURES: Exercise capacity measured as peak oxygen consumption (V̇O2, mL/kg/min; co-primary outcome) and QOL measured by the Minnesota Living with Heart Failure (MLHF) Questionnaire (score range: 0-105, higher scores indicate worse heart failure-related QOL; co-primary outcome). RESULTS: Of the 100 enrolled participants, 26 participants were randomized to exercise; 24 to diet; 25 to exercise + diet; 25 to control. Of these, 92 participants completed the trial. Exercise attendance was 84% (SD, 14%) and diet adherence was 99% (SD, 1%). By main effects analysis, peak V̇O2 was increased significantly by both interventions: exercise, 1.2 mL/kg body mass/min (95% CI, 0.7 to 1.7), P < .001; diet, 1.3 mL/kg body mass/min (95% CI, 0.8 to 1.8), P < .001. The combination of exercise + diet was additive (complementary) for peak V̇O2 (joint effect, 2.5 mL/kg/min). There was no statistically significant change in MLHF total score with exercise and with diet (main effect: exercise, -1 unit [95% CI, -8 to 5], P = .70; diet, -6 units [95% CI, -12 to 1], P = .08). The change in peak V̇O2 was positively correlated with the change in percent lean body mass (r = 0.32; P = .003) and the change in thigh muscle:intermuscular fat ratio (r = 0.27; P = .02). There were no study-related serious adverse events. Body weight decreased by 7% (7 kg [SD, 1]) in the diet group, 3% (4 kg [SD, 1]) in the exercise group, 10% (11 kg [SD, 1] in the exercise + diet group, and 1% (1 kg [SD, 1]) in the control group. CONCLUSIONS AND RELEVANCE: Among obese older patients with clinically stable HFPEF, caloric restriction or aerobic exercise training increased peak V̇O2, and the effects may be additive. Neither intervention had a significant effect on quality of life as measured by the MLHF Questionnaire. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00959660.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The study concluded that secondary outcomes (improved metabolic measures) could be generalized to the senior population (age ≥ 65 years), with evidence that weight loss intervention for older adults is effective in improving health outcomes [9,10].”
From Clinical and Economic Impact of a Digital, Remotely-Delivered Intensive Behavioral Counseling Program on Medicare Beneficiaries at Risk for Diabetes and Cardiovascular Disease (2016) · cites this paper as [10]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“A randomized trial of caloric restriction in patients with heart failure with preserved ejection fraction and obesity showed reductions in symptoms and improvements in exercise function and quality of life. 30”
From Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity (2023) · cites this paper as [30]
The cited source says what the claim attributes to it.
In the citing paper
“previous data suggesting that health status and exercise function improve with lifestyle modification-mediated weight loss in patients with heart failure with preserved ejection fraction and obesity, 30”
From Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity (2023) · cites this paper as [30]
The cited source says what the claim attributes to it.
In the citing paper
“Evidence in the past several years shows relatively rapid and sizeable improvements in major heart failure symptoms with drug-induced and lifestyle-induced weight loss among people with heart failure with preserved ejection fraction.110,111”
From Definition and diagnostic criteria of clinical obesity (2025) · cites this paper as [111]
The cited source says what the claim attributes to it.
In the citing paper
“In ten trials, a weight-reducing diet alone resulted in the desired weight loss, which consisted of fat mass as well as lean mass (290)(291)(292)(294)(295)(296)(297)(298)(299).”
From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [298]
In the citing paper
“Several studies reported that (modest) weight loss caused by lifestyle interventions in obesity-related HFpEF patients improved exercise capacity but had no effect on cardiac structure or function.”
From The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF (2023) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1992) · PubMed · Cited by 33,716
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Trends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction
Owan, T., Hodge, D. O., Herges, R. M., Jacobsen, S. J., Roger, V. L., & Redfield, M. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052256 · Cited by 4,209
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093
Rich, M. W., Beckham, V., Wittenberg, C., Leven, C. L., Freedland, K. E., & Carney, R. M. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511023331806 · Cited by 2,327
Bariatric Surgery and Long-term Cardiovascular Events
Sjöström, L., Peltonen, M., Jacobson, P., Sjöström, C. D., Karason, K., Wedel, H., Ahlin, S., Anveden, Å., Bengtsson, C., Bergmark, G., et al. (2012) · JAMA · doi:10.1001/jama.2011.1914 · Cited by 1,656
Redfield, M. M., Chen, H. H., Borlaug, B. A., Semigran, M. J., Lee, K. L., Lewis, G. D., LeWinter, M. M., Rouleau, J. L., Bull, D. A., Mann, D. L., et al. (2013) · JAMA · doi:10.1001/jama.2013.2024 · Cited by 1,164
Weight loss, exercise, or both and physical function in obese older adults
Villareal, D. T., Chode, S., Parimi, N., Sinacore, D. R., Hilton, T., Armamento-Villareal, R., Napoli, N., Qualls, C., & Shah, K. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1008234 · Cited by 1,096
Rector, T. S., & Cohn, J. N. (1992) · American Heart Journal · doi:10.1016/0002-8703(92)90986-6 · Cited by 1,020
Kitzman, D. W. (2002) · JAMA · doi:10.1001/jama.288.17.2144 · Cited by 883
Self-citation
Cited by
Sorted by citations
Items 101–200 of 921
Marso, S. P., Baeres, F. M. M., Bain, S. C., Goldman, B., Husain, M., Nauck, M. A., Poulter, N. R., Pratley, R. E., Thomsen, A. B., & Buse, J. B. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.063 · Cited by 118
Pathophysiology of heart failure and frailty: a common inflammatory origin?
Bellumkonda, L., Tyrrell, D. J., Hummel, S. L., & Goldstein, D. R. (2017) · Aging Cell · doi:10.1111/acel.12581 · Cited by 123
Mahajan, R., Stokes, M. B., Elliott, A. D., Munawar, D. A., Khokhar, K. B., Thiyagarajah, A., Hendriks, J., Linz, D., Gallagher, C., Kaye, D. M., et al. (2019) · Heart · doi:10.1136/heartjnl-2019-314770 · Cited by 120
Long-Term Changes in Cardiac Structure and Function Following Bariatric Surgery
Sorimachi, H., Obokata, M., Omote, K., Reddy, Y. N. V., Takahashi, N., Koepp, K. E., Ng, A. C. T., Rider, O. J., & Borlaug, B. A. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.08.738 · Cited by 117
Update on obesity, the obesity paradox, and obesity management in heart failure
Alebna, P. L., Mehta, A., Yehya, A., daSilva‐deAbreu, A., Lavie, C. J., & Carbone, S. (2024) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2024.01.003 · Cited by 120
Cardio-Oncology and Heart Failure: a Scientific Statement From the Heart Failure Society of America
Bloom, M. W., Vo, J. B., Rodgers, J. E., FERRARI, A. M., Nohria, A., Deswal, A. M., Cheng, R. K.-H., Kittleson, M. M., Upshaw, J. N., Palaskas, N. L., et al. (2024) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2024.08.045 · Cited by 128
von Haehling, S., Arzt, M. E., Doehner, W., Edelmann, F., Evertz, R., Ebner, N., Herrmann‐Lingen, C., Garfias‐Veitl, T., Koziolek, M. J., Noutsias, M., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1838 · Cited by 119
Reddy, Y. N. V., Carter, R. E., Sundaram, V., Kaye, D. M., Handoko, M. L., Tedford, R. J., Andersen, M. J., Sharma, K., Obokata, M., Verbrugge, F. H., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03140-1 · Cited by 121
Impaired Exercise Tolerance in Heart Failure With Preserved Ejection Fraction
Nayor, M. G., Houstis, N. E., Namasivayam, M. J., Rouvina, J. N., Hardin, C. C., Shah, R. V., Ho, J. E., Malhotra, R. K., & Lewis, G. D. (2020) · JACC Heart Failure · doi:10.1016/j.jchf.2020.03.008 · Cited by 112
Scandalis, L., Kitzman, D. W., Nicklas, B. J., Lyles, M. F., Brubaker, P. H., Nelson, M. B., Gordon, M., Stone, J., Bergstrom, J., Neufer, P. D., et al. (2023) · JAMA Cardiology · doi:10.1001/jamacardio.2023.0957 · Cited by 112
Self-citationKosiborod, M. N., Abildstrøm, S. Z., Borlaug, B. A., Butler, J., Christensen, L., Davies, M., Hovingh, K. G., Kitzman, D. W., Lindegaard, M. L., Møller, D. V., et al. (2023) · JACC: Heart Failure · doi:10.1016/j.jchf.2023.05.010 · Cited by 97
Self-citationAutophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management
Zhang, Y., Whaley‐Connell, A. T., Sowers, J. R., & Ren, J. T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.06.004 · Cited by 109
Dietary Management of Heart Failure: DASH Diet and Precision Nutrition Perspectives
Wickman, B. E., Enkhmaa, B., Ridberg, R. A., Romero, E., Cadeiras, M., Meyers, F., & Steinberg, F. M. (2021) · Nutrients · doi:10.3390/nu13124424 · Cited by 120
Dalos, D., Mascherbauer, J., Zotter‐Tufaro, C., Duca, F., Kammerlander, A. A., Aschauer, S., & Bonderman, D. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.04.052 · Cited by 113
da Silveira, A. D., de Lima, J. B., Piardi, D. S., Macedo, D. D. S., Zanini, M., Nery, R. M., Laukkanen, J. A., & Stein, R. (2020) · European Journal of Preventive Cardiology · doi:10.1177/2047487319901206 · Cited by 107
“Atrial fibrillation was an exclusion criterion for some studies(11,27) and showed very low prevalence in the total sample of other trials, as well as in the present study.(8,10) Some previous studies including patients with HFpEF showed that baseline peak VO2 was slightly lower compared with our patient population.”
InfluentialLourenço, A. P., Leite-Moreira, A. F., Balligand, J., Bauersachs, J. K., Dawson, D. K., de Boer, R. A., Windt, L. J. D., Falcão‐Pires, I., Fontes‐Carvalho, R., Franz, S., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.1059 · Cited by 109
Heart failure with preserved ejection fraction: controversies, challenges and future directions
Zakeri, R., & Cowie, M. (2018) · Heart · doi:10.1136/heartjnl-2016-310790 · Cited by 107
Therapeutic approaches in heart failure with preserved ejection fraction: past, present, and future
Wintrich, J., Kindermann, I., Ukena, C., Selejan, S., Werner, C. M., Maack, C., Laufs, U., Tschöpe, C., Anker, S. D., Lam, C. S. P., et al. (2020) · Clinical Research in Cardiology · doi:10.1007/s00392-020-01633-w · Cited by 106
The role of diet and nutrition in heart failure: A state-of-the-art narrative review
Billingsley, H. E., Hummel, S. L., & Carbone, S. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.08.004 · Cited by 106
Inflammation in Obesity-Related HFpEF
Verma, S., Petrie, M. C., Borlaug, B. A., Butler, J., Davies, M. J., Kitzman, D. W., Shah, S. J., Rönnbäck, C., Abildstrom, S. Z., Liisberg, K., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.08.028 · Cited by 113
Self-citationFilippatos, G. S., Maggioni, A. P., Lam, C. S. P., Pieske‐Kraigher, E., Butler, J., Spertus, J. A., Ponikowski, P. P., Shah, S. J., Solomon, S. D., Scalise, A., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.800 · Cited by 103
Therapeutic Manipulation of Myocardial Metabolism
Honka, H., Solis‐Herrera, C., Triplitt, C. L., Norton, L., Butler, J., & DeFronzo, R. A. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.02.057 · Cited by 101
Lifestyle Medicine and the Management of Cardiovascular Disease
Doughty, K. N., Pilar, N. X. D., Audette, A., & Katz, D. L. (2017) · Current Cardiology Reports · doi:10.1007/s11886-017-0925-z · Cited by 109
von Haehling, S., Doehner, W., Evertz, R., Garfias‐Veitl, T., Derad, C., Diek, M., Karakas, M., Birkemeyer, R., Fillippatos, G., Lainščak, M., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae479 · Cited by 103
Upadhya, B., Pisani, B., & Kitzman, D. W. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15141 · Cited by 94
Self-citationPandey, A., Segar, M. W., Singh, S., Reeves, G. R., O’Connor, C. J., Piña, I. L., Whellan, D. J., Kraus, W. E., Mentz, R. J., & Kitzman, D. W. (2022) · Circulation · doi:10.1161/circulationaha.122.059983 · Cited by 96
Self-citationMentz, R. J., Whellan, D. J., Reeves, G. R., Pastva, A. M., Duncan, P. W., Upadhya, B., Nelson, M. B., Chen, H., Reed, S. D., Rosenberg, P. B., et al. (2021) · JACC Heart Failure · doi:10.1016/j.jchf.2021.05.007 · Cited by 95
Self-citationPeters, A. E., Tromp, J., Shah, S. J., Lam, C. S. P., Lewis, G. D., Borlaug, B. A., Sharma, K., Pandey, A., Sweitzer, N. K., Kitzman, D. W., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac179 · Cited by 91
Self-citationMa, C., Luo, H., Fan, L., Liu, X., & Gao, C. (2020) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20209646 · Cited by 95
Obese Heart Failure With Preserved Ejection Fraction Phenotype
Kitzman, D. W., & Lam, C. S. P. (2017) · Circulation · doi:10.1161/circulationaha.117.028365 · Cited by 87
Self-citationImpaired Exercise Tolerance in Heart Failure: Role of Skeletal Muscle Morphology and Function
Tucker, W. J., Haykowsky, M. J., Seo, Y., Stehling, E., & Forman, D. E. (2018) · Current Heart Failure Reports · doi:10.1007/s11897-018-0408-6 · Cited by 87
Self-citationRoh, J. D., Houstis, N. E., Yu, A., Chang, B. J., Yeri, A., Li, H., Hobson, R., Lerchenmüller, C., Vujić, A., Chaudhari, V., et al. (2020) · Aging Cell · doi:10.1111/acel.13159 · Cited by 95
Brubaker, P. H., Nicklas, B. J., Houston, D. K., Hundley, W. G., Chen, H., Molina, A. J. A., Lyles, W. M., Nelson, B., Upadhya, B., Newland, R., et al. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.122.010161 · Cited by 87
Self-citationTreatment of obesity in older persons—A systematic review
Haywood, C., & Sumithran, P. (2019) · Obesity Reviews · doi:10.1111/obr.12815 · Cited by 84
Pagel, P. S., Tawil, J. N., Boettcher, B. T., Izquierdo, D. A., Lazicki, T. J., Crystal, G. J., & Freed, J. K. (2020) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2020.07.016 · Cited by 86
Sex and central obesity in heart failure with preserved ejection fraction
Sorimachi, H., Omote, K., Omar, M., Popović, D., Verbrugge, F. H., Reddy, Y. N. V., Lin, G., Obokata, M., Miles, J. M., Jensen, M. D., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2563 · Cited by 86
Beavers, K. M., Ambrosius, W. T., Rejeski, W. J., Burdette, J. H., Walkup, M. P., Sheedy, J. L., Nesbit, B. A., Gaukstern, J. E., Nicklas, B. J., & Marsh, A. P. (2017) · Obesity · doi:10.1002/oby.21977 · Cited by 96
Self-citationShaltout, H. A., Eggebeen, J., Marsh, A. P., Brubaker, P. H., Laurienti, P. J., Burdette, J. H., Basu, S., Morgan, A. R., Santos, P. C. D., Norris, J. L., et al. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.05.005 · Cited by 85
Self-citationMiller, A., McNamara, J. L., Hummel, S. L., Konerman, M. C., & Tincopa, M. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-69013-y · Cited by 81
Kasiakogias, A., Rosei, E. A., Camafort, M., Ehret, G., Faconti, L., Ferreira, J. P., Brguljan-Hitij, J., Januszewicz, A., Kahan, T., Manolis, A. J., et al. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002910 · Cited by 81
Heart failure with preserved ejection fraction: current management and future strategies
Tschöpe, C., Birner, C. M., Böhm, M., Bruder, O., Frantz, S., Luchner, A., Maier, L. S., Störk, S., Kherad, B., & Laufs, U. (2017) · Clinical Research in Cardiology · doi:10.1007/s00392-017-1170-6 · Cited by 80
Contemporary pharmacological treatment and management of heart failure
Bozkurt, B. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-00997-0 · Cited by 86
Selvaraj, S., Kim, J., Ansari, B. A., Zhao, L., Cvijic, M. E., Fronheiser, M. P., Vanjarapu, J. M.-R., Kumar, A. A., Suri, A., Yenigalla, S., et al. (2020) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2020.07.022 · Cited by 78
Saito, H., Matsue, Y., Kamiya, K., Kagiyama, N., Maeda, D., Endo, Y., Ueno, H., Yoshioka, K., Mizukami, A., Saito, K., et al. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03168-3 · Cited by 78
The challenge of frailty and sarcopenia in heart failure with preserved ejection fraction
Kinugasa, Y., & Yamamoto, K. (2016) · Heart · doi:10.1136/heartjnl-2016-309995 · Cited by 79
2025 ACC Scientific Statement on the Management of Obesity in Adults With Heart Failure
Kittleson, M. M., Benjamin, E. J., Blumer, V., Harrington, J., Januzzi, J. L., McMurray, J. J. V., & Vest, A. R. (2025) · JACC · doi:10.1016/j.jacc.2025.05.008 · Cited by 79
Obokata, M., Sorimachi, H., Harada, T., Kagami, K., Saito, Y., & Ishii, H. (2023) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2022.09.018 · Cited by 83
Carbone, S., Canada, J. M., Buckley, L. F., Trankle, C. R., Billingsley, H., Dixon, D. L., Mauro, A. G., Dessie, S., Kadariya, D., Mezzaroma, E., et al. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.06.009 · Cited by 77
Epidemiology and Clinical Features of Heart Failure with Preserved Ejection Fraction
TERAMOTO, K., Teng, T. K., Chandramouli, C., Tromp, J., Sakata, Y., & Lam, C. S. P. (2022) · Cardiac failure review · doi:10.15420/cfr.2022.06 · Cited by 76
Obesity Contributes to Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
Carbone, S., Canada, J. M., Buckley, L. F., Trankle, C. R., Dixon, D. L., Buzzetti, R., Arena, R. A., Tassell, B. W. V., & Abbate, A. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.08.072 · Cited by 76
Heart failure with preserved ejection fraction based on aging and comorbidities
Lin, Y. H., Fu, S., Yao, Y., Li, Y., Zhao, Y., & Luo, L. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02935-x · Cited by 81
The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF
Withaar, C., Meems, L. M. G., Nollet, E. E., Schouten, E. M., Schroeder, M. A., Knudsen, L. B., Niss, K., Madsen, C. T., Hoegl, A., Mazzoni, G., et al. (2023) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2023.05.012 · Cited by 74
Effects of intentional weight loss in patients with obesity and heart failure: a systematic review
McDowell, K., Petrie, M. C., Raihan, N. A., & Logue, J. (2018) · Obesity Reviews · doi:10.1111/obr.12707 · Cited by 73
The Impact of Obesity in Heart Failure
Carbone, S., Lavie, C. J., Elagizi, A., Arena, R. A., & Ventura, H. O. (2019) · Heart Failure Clinics · doi:10.1016/j.hfc.2019.08.008 · Cited by 78
Tucker, W. J., Lijauco, C. C., Hearon, C. M., Angadi, S. S., Nelson, M. D., Sarma, S., Nanayakkara, S., Gerche, A. L., & Haykowsky, M. J. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.07.002 · Cited by 72
Self-citationWawrzeńczyk, A., Anaszewicz, M., Wawrzeńczyk, A., & Budzyński, J. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09793-2 · Cited by 74
Pharmacotherapy for obesity management in adults: 2025 clinical practice guideline update
Pedersen, S. D., Manjoo, P., Dash, S., Jain, A., Pearce, N., & Poddar, M. (2025) · Canadian Medical Association Journal · doi:10.1503/cmaj.250502 · Cited by 78
Obesity and heart failure with preserved ejection fraction: a paradox or something else?
Tadic, M. V., & Cuspidi, C. (2019) · Heart Failure Reviews · doi:10.1007/s10741-018-09766-x · Cited by 71
Tassell, B. W. V., Buckley, L. F., Carbone, S., Trankle, C. R., Canada, J. M., Dixon, D. L., Abouzaki, N. A., Oddi, C., Biondi‐Zoccai, G., Arena, R. A., et al. (2017) · Clinical Cardiology · doi:10.1002/clc.22719 · Cited by 70
Chen, F., Su, W., Becker, S. H., Payne, M., Castro Sweet, C. M., Peters, A. L., & Dall, T. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0163627 · Cited by 60
Pivotal Role of Excess Intra-Abdominal Adipose in the Pathogenesis of Metabolic/Obese HFpEF
Kitzman, D. W., & Nicklas, B. J. (2018) · JACC: Heart Failure · doi:10.1016/j.jchf.2018.08.007 · Cited by 67
Self-citationObesity accelerates cardiovascular ageing
Ruperez, C., Madeo, F., de Cabo, R., Kroemer, G., & Abdellatif, M. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf216 · Cited by 73
Heart Failure with Preserved Ejection Fraction in Older Adults
Upadhya, B., & Kitzman, D. W. (2017) · Heart Failure Clinics · doi:10.1016/j.hfc.2017.02.005 · Cited by 69
Self-citationRuiz-Meana, M., Bou-Teen, D., Ferdinandy, P., Gyongyosi, M., Pesce, M., Perrino, C., Schulz, R., Sluijter, J. P. G., Tocchetti, C. G., Thum, T., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa132 · Cited by 67
Buono, M. G. D., Iannaccone, G., Scacciavillani, R., Carbone, S., Camilli, M., Niccoli, G., Borlaug, B. A., Lavie, C. J., Arena, R. A., Crea, F., et al. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.04.011 · Cited by 70
Physical activity, exercise and cardiac troponins: Clinical implications
Aakre, K. M., & Omland, T. (2019) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2019.02.005 · Cited by 69
Packer, M. (2019) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2019.09.002 · Cited by 65
de Lucia, C., Gambino, G., Petraglia, L., Elia, A., Komici, K., Femminella, G. D., D’Amico, M. L., Formisano, R., Borghetti, G., Liccardo, D., et al. (2018) · Circulation Heart Failure · doi:10.1161/circheartfailure.117.004153 · Cited by 64
Ndumele, C. E., Rodríguez, F., Dixon, D. L., Khan, S. S., Mukherjee, D., Bajaj, M. S., Bangalore, S., Bozkurt, B., Breathett, K. K., Clarke, S. L., et al. (2026) · Circulation · doi:10.1161/cir.0000000000001453 · Cited by 101
Kitzman, D. W., Haykowsky, M. J., & Tomczak, C. R. (2017) · Circulation Heart Failure · doi:10.1161/circheartfailure.117.004281 · Cited by 63
Self-citationTargeting obesity and diabetes to treat heart failure with preserved ejection fraction
Altara, R., Giordano, M., Nordén, E. S., Cataliotti, A., Kurdi, M., Bajestani, S. N., & Booz, G. W. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00160 · Cited by 61
Packer, M. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1646 · Cited by 67
Gevaert, A. B., Lemmens, K., Vrints, C. J., & Craenenbroeck, E. M. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4865756 · Cited by 60
Edelmann, F., Wachter, R., Duvinage, A., Mueller, S., Fegers‐Wustrow, I., Schwarz, S., Christle, J. W., Pieske‐Kraigher, E., Seyfarth, M., Knapp, M., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03342-7 · Cited by 64
Self-citationBillingsley, H., Rodriguez‐Miguelez, P., Buono, M. G. D., Abbate, A., Lavie, C. J., & Carbone, S. (2019) · Nutrients · doi:10.3390/nu11122849 · Cited by 63
Obesity-Related Heart Failure with Preserved Ejection Fraction
Harada, T., & Obokata, M. (2020) · Heart Failure Clinics · doi:10.1016/j.hfc.2020.02.004 · Cited by 60
Sarcopenic Obesity and Cardiovascular Disease: An Overlooked but High-Risk Syndrome
Mirzai, S., Carbone, S., Batsis, J. A., Kritchevsky, S. B., Kitzman, D. W., & Shapiro, M. D. (2024) · Current Obesity Reports · doi:10.1007/s13679-024-00571-2 · Cited by 67
Self-citationCurrent Perspectives on Systemic Hypertension in Heart Failure with Preserved Ejection Fraction
Tam, M., Lee, R., CASCINO, T. M., Konerman, M. C., & Hummel, S. L. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0709-2 · Cited by 57
Heart Failure with Preserved Ejection Fraction in Women
Tibrewala, A., & Yancy, C. W. (2018) · Heart Failure Clinics · doi:10.1016/j.hfc.2018.08.002 · Cited by 58
Compensation in response to energy deficits induced by exercise or diet
Doucet, É., McInnis, K., & Mahmoodianfard, S. (2018) · Obesity Reviews · doi:10.1111/obr.12783 · Cited by 61
Hajj, E. C. E., Hajj, M. C. E., Sykes, B., Lamicq, M., Zile, M. R., Malcolm, R., O’Neil, P. M., & Litwin, S. E. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022930 · Cited by 58
Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease
Forman, D. E., Kuchel, G. A., Newman, J. C., Kirkland, J. L., Volpi, E., Taffet, G. E., Barzilai, N., Pandey, A., Kitzman, D. W., Libby, P., et al. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.05.038 · Cited by 64
Self-citationLeggio, M., Fusco, A., Loreti, C., Limongelli, G., Bendini, M. G., Mazza, A., Coraci, D., & Padua, L. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09841-x · Cited by 62
Smolgovsky, S. A., Bayer, A. L., Kaur, K., Sanders, E. K., Aronovitz, M. A., Filipp, M. E., Thorp, E. B., Schiattarella, G. G., Hill, J. A., Blanton, R. M., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci171874 · Cited by 56
2026 ESC Guidelines for the management of heart failure
Køber, L., Adamo, M., Ruwald, A., Tomasoni, D., Anderson, L., Andersson, C., Brugts, J. J., Chioncel, O. D., Donal, E., Ferdinandy, P., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag100 · Cited by 109
O'Byrne, M. L., Kim, S., Hornik, C. P. V., Yerokun, B. A., Matsouaka, R., Jacobs, J. P., Jacobs, M. L., & Jonas, R. A. (2017) · Circulation · doi:10.1161/circulationaha.116.026778 · Cited by 56
Liu, X., Guo, L., Xiao, K., Zhu, W., Liu, M., Wan, R., & Hong, K. (2019) · Obesity Reviews · doi:10.1111/obr.12970 · Cited by 56
Ndumele, C. E., Rodriguez, F., Dixon, D. L., Khan, S. S., Mukherjee, D., Bajaj, M., Bangalore, S., Bozkurt, B., Breathett, K., Clarke, S. L., et al. (2026) · JACC · doi:10.1016/j.jacc.2026.03.056 · Cited by 90
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01130-5 · Cited by 59
Heart Failure With Preserved Ejection Fraction as an Exercise Deficiency Syndrome
Gerche, A. L., Howden, E. J., Haykowsky, M. J., Lewis, G. D., Levine, B. D., & Kovacic, J. C. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.07.011 · Cited by 58
Self-citationWeight loss enhances cardiac energy metabolism and function in heart failure associated with obesity
Karwi, Q. G., Zhang, L., Altamimi, T., Wagg, C. S., Patel, V. B., Uddin, G. M., Joerg, A. R., Padwal, R. S., Johnstone, D. E., Sharma, A. M., et al. (2019) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13762 · Cited by 57
Zouhal, H., Abderrahman, A. B., Khodamoradi, A., Saeidi, A., Jayavel, A., Hackney, A. C., Laher, I., Algotar, A. M., & Jabbour, G. (2020) · Obesity Reviews · doi:10.1111/obr.13039 · Cited by 66
Pearson, M. J., Mungovan, S. F., & Smart, N. A. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9600-0 · Cited by 54
Stehlik, J., Rodriguez-Correa, C., Spertus, J. A., Biber, J. E., Nativi-Nicolau, J. N., Zickmund, S. L., Steinberg, B. A., Peritz, D. C., Walker, A. M., Hess, J. A., et al. (2017) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2017.09.009 · Cited by 54
Fukuma, N., Hasumi, E., Fujiu, K., Waki, K., Toyooka, T., Komuro, I., & Ohe, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-48267-1 · Cited by 53
Tegegne, T. K., Rawstorn, J. C., Nourse, R. A., Kibret, K. T., Ahmed, K. Y., & Maddison, R. (2022) · Open Heart · doi:10.1136/openhrt-2021-001949 · Cited by 58
Bonfioli, G. B., Rodella, L., Metra, M., & Vizzardi, E. (2024) · Heart Failure Reviews · doi:10.1007/s10741-024-10450-6 · Cited by 58
Upadhya, B., Hundley, W. G., Brubaker, P. H., Morgan, T. M., Stewart, K. P., & Kitzman, D. W. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14940 · Cited by 55
Self-citationAutophagy in cardiovascular health and disease
Abdellatif, M., Ljubojević-Holzer, S., Madeo, F., & Sedej, S. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.022 · Cited by 54
Houston, D. K., Neiberg, R. H., Miller, M. E., Hill, J. O., Jakicic, J. M., Johnson, K. C., Gregg, E. W., Hubbard, V. S., Pi-Sunyer, X., Rejeski, W. J., et al. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx204 · Cited by 52
Metadata
- Authors
- Kitzman, D. W., Brubaker, P., Morgan, T., Haykowsky, M., Hundley, G., Kraus, W. E., Eggebeen, J., & Nicklas, B. J.
- Affiliations
- Wake Forest University Health Sciences (US)
- Wake Forest University (US)
- The University of Texas at Arlington (US)
- Cardiology Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina
- Duke University (US)
- Emory University (US)
- Corresponding author
- Kitzman, Dalane W.
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2016-01-05
- Volume
- 315
- Issue
- 1
- Pages
- 36
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC4787295
- OpenAlex
- W2231944090
- Cited by
- 921
- References
- 44
- Citations by year
- 2026: 94 · 2025: 117 · 2024: 121 · 2023: 89 · 2022: 92 · 2021: 92 · 2020: 90 · 2019: 69 · 2018: 60 · 2017: 66 · 2016: 29
- FWCI
- 153.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Texas at Arlington
- National Institutes of Health (UL1TR001420, R01AG18915)
- Wake Forest School of Medicine (P30AG021332)
- National Institute on Aging (R01AG020583, R01 AG18915, R01AG018915, R37AG018915, P30AG021332)
- National Heart, Lung, and Blood Institute (R01HL093713)
- National Center for Research Resources (M01RR007122)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- heart failure with preserved ejection fraction, obesity, older adults, caloric restriction, aerobic exercise training, peak oxygen uptake, exercise capacity, quality of life, diet and exercise combination, exercise intolerance, heart failure
- MeSH terms
- Aged, Body Composition, Combined Modality Therapy, Female, Heart Failure, Humans, Male, Middle Aged, Obesity, Oxygen Consumption, Patient Compliance, Quality of Life, Surveys and Questionnaires, Stroke Volume, Weight Loss, Exercise, Body Mass Index, Single-Blind Method, Exercise Tolerance, Caloric Restriction, Physical Conditioning, Human
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
