Cardiomyocyte ageing and cardioprotection: consensus document from the ESC working groups cell biology of the heart and myocardial function
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Advanced age is a major predisposing risk factor for the incidence of coronary syndromes and comorbid conditions which impact the heart response to cardioprotective interventions. Advanced age also significantly increases the risk of developing post-ischaemic adverse remodelling and heart failure after ischaemia/reperfusion (IR) injury. Some of the signalling pathways become defective or attenuated during ageing, whereas others with well-known detrimental consequences, such as glycoxidation or proinflammatory pathways, are exacerbated. The causative mechanisms responsible for all these changes are yet to be elucidated and are a matter of active research. Here, we review the current knowledge about the pathophysiology of cardiac ageing that eventually impacts on the increased susceptibility of cells to IR injury and can affect the efficiency of cardioprotective strategies.
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Because mature cardiomyocytes have a low proliferation rate, the injured area in the aging heart is replaced by fibrotic scar tissue, resulting in organ failure.
“In addition, because mature cardiomyocytes have a low rate of proliferation, the injured area in the aging heart is replaced by fibrotic scar tissue, resulting in organ failure.141”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [141]
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Sorted by citations
Inflammation and aging: signaling pathways and intervention therapies
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“In addition, because mature cardiomyocytes have a low rate of proliferation, the injured area in the aging heart is replaced by fibrotic scar tissue, resulting in organ failure.(141) The main effector cells in cardiac fibrosis are activated myofibroblasts.”
BackgroundAn interferon gamma response signature links myocardial aging and immunosenescence
Ashour, D., Rebs, S., Arampatzi, P., Saliba, A.-E., Dudek, J., Schulz, R., Hofmann, U., Frantz, S., Cochain, C., Streckfuß-Bömeke, K., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad068 · Cited by 39 · see citing works
Self-citation
- Authors
- Ruiz-Meana, M., Bou-Teen, D., Ferdinandy, P., Gyongyosi, M., Pesce, M., Perrino, C., Schulz, R., Sluijter, J. P. G., Tocchetti, C. G., Thum, T., & Madonna, R.
- Affiliations
- Department of Cardiology, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autonoma de Barcelona and Centro de Investigación Biomédica en Red-CV, CIBER-CV , Madrid,
- Semmelweis University (HU)
- Department of Cardiology, Medical University of Vienna , Waehringer Guertel 18-20, A-1090 Vienna,
- Centro Cardiologico Monzino (IT)
- Federico II University Hospital (IT)
- Justus-Liebig-Universität Gießen (DE)
- Utrecht University (NL)
- Medizinische Hochschule Hannover (DE)
- University of Pisa (IT)
- Corresponding author
- Madonna, Rosalinda
- ORCID
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-05-08
- Volume
- 116
- Issue
- 11
- Pages
- 1835-1849
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- OpenAlex
- W3023592989
- Cited by
- 67
- References
- 158
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 9 · 2023: 11 · 2022: 13 · 2021: 7 · 2020: 4
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- COST Action EU-CARDIOPROTECTION (CA16225)
- COST
- European Cooperation in Science and Technology
- ISCIII (PI19-01196)
- European Regional Development Fundings
- Federico II University
- Ricerca di Ateneo
- Incyte s.r.l. and from Ministero dell’Istruzione
- Università e Ricerca Scientifica (549901_2020)
- National Research, Development and Innovation Office of Hungary
- National Heart Program (NVKP 16-1-2016-0017)
- Higher Education Institutional Excellence Program
- Ministry of Human Capacities in Hungary
- Therapeutic Devepment
- Semmelweis University
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- cardiac aging, cardiomyocytes, cardioprotection, ischemia-reperfusion injury, heart failure, glycoxidation, inflammation, signaling pathways, coronary syndrome, old age
- MeSH terms
- Heart Disease Risk Factors, Age Factors, Aging, Animals, Disease Models, Animal, Extracellular Matrix, Heart Diseases, Humans, Phenotype, Prognosis, Cellular Senescence, Risk Assessment, Myocytes, Cardiac
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