Obesity accelerates cardiovascular ageing
Open accessAbstract
A global obesity pandemic, coupled with an increasingly ageing population, is exacerbating the burden of cardiovascular disease. Indeed, clinical and experimental evidence underscores a potential connection between obesity and ageing in the pathogenesis of various cardiovascular disorders. This is further supported by the notion that weight reduction not only effectively reduces major cardiovascular events in elderly individuals but is also considered the gold standard for lifespan extension, in obese and non-obese model organisms. This review evaluates the intricate interplay between obesity and ageing from molecular mechanisms to whole organ function within the cardiovascular system. By comparatively analysing their characteristic features, shared molecular and cell biological signatures between obesity and ageing are unveiled, with the intent to shed light on how obesity accelerates cardiovascular ageing. This review also elaborates on how emerging metabolic interventions targeting obesity might protect from cardiovascular diseases largely through antagonizing key molecular mechanisms of the ageing process itself. In sum, this review aims to provide valuable insight into how understanding these interconnected processes could guide the development of novel and effective cardiovascular therapeutics for a growing aged population with a concerning obesity problem.
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Obesity substantially increases the risk of diabetes, cardiovascular disease, fatty liver disease, and certain cancers.
“Obesity substantially increases the risk of diabetes, cardiovascular disease, fatty liver disease, and certain cancers, while imposing enormous societal and economic burdens.[2][3][4]”
From The Triple‐Agonist Revolution: Retatrutide and the Paradigm Shift in Multi‐Hormonal Pharmacotherapy for Obesity and Cardiometabolic Comorbidities (2026) · cites this paper as [3]
The Introduction links obesity to increased cardiovascular risk, and the Figure 5 caption in the concluding remarks lists type 2 diabetes among conditions associated with obesity. The passages in our copy do not establish the claimed increased risk of fatty liver disease or certain cancers. (LLM, conf=0.87)
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Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724 · see citing works
Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
Marso, S. P., Daniels, G. H., Brown-Frandsen, K., Kristensen, P., Mann, J. F. E., Nauck, M. A., Nissen, S. E., Pocock, S., Poulter, N. R., Ravn, L. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603827 · Cited by 7,629 · see citing works
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911 · see citing works
Once-Weekly Semaglutide in Adults with Overweight or Obesity
Wilding, J. P. H., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., McGowan, B. M., Rosenstock, J., Tran, M. T. D., Wadden, T. A., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2032183 · Cited by 5,205 · see citing works
Prospective Studies Collaboration (2009) · The Lancet · doi:10.1016/s0140-6736(09)60318-4 · Cited by 4,807 · see citing works
Tirzepatide Once Weekly for the Treatment of Obesity
Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., Kiyosue, A., Zhang, S., Liu, B., Bunck, M. C., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2206038 · Cited by 3,838 · cited 1× · see citing works
“259,260 Indeed, in a Phase 3 trial, tirzepatide treatment of patients with obesity and HFpEF significantly lowered the risk of cardiovascular death and heart failure worsening.”
Obesity and cardiovascular disease: a scientific statement from the American Heart Association
Powell-Wiley, T. M., Poirier, P., Burke, L. E., Després, J.-P., Gordon-Larsen, P., Lavie, C. J., Lear, S. A., Ndumele, C. E., Neeland, I. J., Sanders, P., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000973 · Cited by 3,691 · see citing works
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes
Lincoff, A. M., Brown-Frandsen, K., Colhoun, H. M., Deanfield, J., Emerson, S. S., Esbjerg, S., Hardt-Lindberg, S., Hovingh, G. K., Kahn, S. E., Kushner, R. F., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2307563 · Cited by 3,236 · see citing works
Poirier, P., Giles, T. D., Bray, G. A., Hong, Y., Stern, J. S., Pi-Sunyer, F. X., & Eckel, R. H. (2006) · Circulation · doi:10.1161/circulationaha.106.171016 · Cited by 3,165 · see citing works
Phelps, N. H., Singleton, R. K., Zhou, B., Heap, R. A., Mishra, A., Bennett, J. E., Paciorek, C. J., Lhoste, V. P., Carrillo-Larco, R. M., Stevens, G. A., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(23)02750-2 · Cited by 2,544 · cited 2× · see citing works
“Although the severity of obesity-related effects on the cardiovascular system largely depends on the duration and grade of obesity, 22 several communalities can be drawn between obesity and ageing with respect to their cardiovascular effects at the whole organ as well as at tissue and cell levels ( Figures 2 and 3 ).”
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works
General and abdominal adiposity and risk of death in Europe
Pischon, T., Boeing, H., Hoffmann, K., Bergmann, M., Schulze, M. B., Overvad, K., van der Schouw, Y. T., Spencer, E., Moons, K. G. M., Tjønneland, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801891 · Cited by 2,155 · see citing works
Obesity Phenotypes, Diabetes, and Cardiovascular Diseases
Piché, M., Tchernof, A., & Després, J. (2020) · Circulation Research · doi:10.1161/circresaha.120.316101 · Cited by 2,046 · see citing works
Ross, R., Neeland, I. J., Yamashita, S., Shai, I., Seidell, J., Magni, P., Santos, R. D., Arsenault, B., Cuevas, A., Hu, F. B., et al. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0310-7 · Cited by 1,966 · see citing works
Mechanisms, Pathophysiology, and Management of Obesity
Heymsfield, S. B., & Wadden, T. A. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1514009 · Cited by 1,867 · see citing works
Sjöström, L. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12012 · Cited by 1,835 · see citing works
Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity
Kosiborod, M. N., Abildstrøm, S. Z., Borlaug, B. A., Butler, J., Rasmussen, S., Davies, M., Hovingh, G. K., Kitzman, D. W., Lindegaard, M. L., Møller, D. V., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2306963 · Cited by 1,669 · cited 1× · see citing works
“214,255 Mechanistically, GLP-1RAs have systemic anti-inflammatory, anti-hypertensive, and lipid-lowering properties that contribute to their beneficial cardiovascular effects.”
Bariatric Surgery and Long-term Cardiovascular Events
Sjöström, L., Peltonen, M., Jacobson, P., Sjöström, C. D., Karason, K., Wedel, H., Ahlin, S., Anveden, Å., Bengtsson, C., Bergmark, G., et al. (2012) · JAMA · doi:10.1001/jama.2011.1914 · Cited by 1,656 · see citing works
Romero-Corral, A., Montori, V. M., Somers, V. K., Korinek, J., Thomas, R. J., Allison, T. G., Mookadam, F., & Lopez-Jimenez, F. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69251-9 · Cited by 1,652 · see citing works
Effects of intermittent fasting on health, aging, and disease
de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605 · see citing works
Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2015) · Circulation Research · doi:10.1161/circresaha.116.305697 · Cited by 1,360 · see citing works
Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.014 · Cited by 1,340 · see citing works
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises
Lakatta, E. G., & Levy, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048893.62841.f7 · Cited by 1,257 · see citing works
Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255 · cited 1× · see citing works
“265,266 In humans, aged patients with overweight and HFpEF exhibit reduced levels of cardiac NAD + .”
Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.022 · Cited by 1,238 · see citing works
The Emerging Risk Factors Collaboration (2011) · The Lancet · doi:10.1016/s0140-6736(11)60105-0 · Cited by 1,216 · see citing works
Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J., & van Deursen, J. M. (2016) · Science · doi:10.1126/science.aaf6659 · Cited by 1,195 · see citing works
Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
Jastreboff, A. M., Kaplan, L. M., Frías, J. P., Wu, Q., Du, Y., Gurbuz, S., Coskun, T., Haupt, A., Milicevic, Z., & Hartman, M. L. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2301972 · Cited by 1,174 · cited 1× · see citing works
“259,260 Indeed, in a Phase 3 trial, tirzepatide treatment of patients with obesity and HFpEF significantly lowered the risk of cardiovascular death and heart failure worsening.”
Cardioprotection and lifespan extension by the natural polyamine spermidine
Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4222 · Cited by 1,168 · see citing works
Self-citationExercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
He, C., Bassik, M. C., Moresi, V., Sun, K., Wei, Y., Zou, Z., An, Z., Loh, J., Fisher, J., Sun, Q., et al. (2012) · Nature · doi:10.1038/nature10758 · Cited by 1,136 · see citing works
Wadden, T. A., Bailey, T. S., Billings, L. K., Davies, M., Frias, J. P., Koroleva, A., Lingvay, I., O’Neil, P. M., Rubino, D. M., Skovgaard, D., et al. (2021) · JAMA · doi:10.1001/jama.2021.1831 · Cited by 1,114 · see citing works
Khan, S. S., Ning, H., Wilkins, J. T., Allen, N., Carnethon, M., Berry, J. D., Sweis, R. N., & Lloyd-Jones, D. M. (2018) · JAMA Cardiology · doi:10.1001/jamacardio.2018.0022 · Cited by 1,072 · see citing works
Ban, K., Noyan-Ashraf, M. H., Hoefer, J., Bolz, S.-S., Drucker, D. J., & Husain, M. (2008) · Circulation · doi:10.1161/circulationaha.107.739938 · Cited by 1,057 · cited 2× · see citing works
“Additionally, GLP-1RAs promote the use of glucose as a metabolic substrate in the myocardium, 210 and inhibit cardiomyocyte apoptosis.”
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity
Packer, M., Zile, M. R., Kramer, C. M., Baum, S. J., Litwin, S. E., Menon, V., Ge, J., Weerakkody, G. J., Ou, Y., Bunck, M. C., et al. (2025) · New England Journal of Medicine · doi:10.1056/nejmoa2410027 · Cited by 1,009 · see citing works
Vaduganathan, M., Docherty, K. F., Claggett, B. L., Jhund, P. S., de Boer, R. A., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M. N., Lam, C. S. P., Martinez, F., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01429-5 · Cited by 996 · see citing works
Vilsboll, T., Christensen, M., Junker, A. E., Knop, F. K., & Gluud, L. L. (2012) · BMJ · doi:10.1136/bmj.d7771 · Cited by 970 · see citing works
Body Mass Index, Waist Circumference, and Health Risk
Janssen, I., Katzmarzyk, P. T., & Ross, R. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.18.2074 · Cited by 958 · see citing works
Obesity, Adipose Tissue and Vascular Dysfunction
Koenen, M., Hill, M. A., Cohen, P., & Sowers, J. R. (2021) · Circulation Research · doi:10.1161/circresaha.121.318093 · Cited by 953 · see citing works
The senescence-associated secretory phenotype and its physiological and pathological implications
Wang, B., Han, J., Elisseeff, J. H., & Demaria, M. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00727-x · Cited by 948 · cited 1× · see citing works
“142 Finally, the identification of senescent cells in tissues is not trivial, because senescence is a heterogeneous phenomenon, 143 rendering the quantification of senolytic effects difficult.”
Lifetime risks of cardiovascular disease
Berry, J. D., Dyer, A., Cai, X., Garside, D. B., Ning, H., Thomas, A., Greenland, P., Van Horn, L., Tracy, R. P., & Lloyd-Jones, D. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1012848 · Cited by 945 · see citing works
Kitzman, D. W., Brubaker, P., Morgan, T., Haykowsky, M., Hundley, G., Kraus, W. E., Eggebeen, J., & Nicklas, B. J. (2016) · JAMA · doi:10.1001/jama.2015.17346 · Cited by 921 · see citing works
Global effect of modifiable risk factors on cardiovascular disease and mortality
The Global Cardiovascular Risk Consortium (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2206916 · Cited by 909 · see citing works
The central role of DNA damage in the ageing process
Schumacher, B., Pothof, J., Vijg, J., & Hoeijmakers, J. H. J. (2021) · Nature · doi:10.1038/s41586-021-03307-7 · Cited by 907 · see citing works
Body Mass Index and the Prevalence of Hypertension and Dyslipidemia
Brown, C., HIGGINS, M. W., Donato, K. A., Rohde, F. C., Garrison, R. J., Obarzanek, E., Ernst, N. D., & Horan, M. J. (2000) · Obesity Research · doi:10.1038/oby.2000.79 · Cited by 851 · see citing works
Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes
Kosiborod, M. N., Petrie, M. C., Borlaug, B. A., Butler, J., Davies, M. J., Hovingh, G. K., Kitzman, D. W., Møller, D. V., Treppendahl, M. B., Verma, S., et al. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2313917 · Cited by 758 · cited 1× · see citing works
“214,255 Mechanistically, GLP-1RAs have systemic anti-inflammatory, anti-hypertensive, and lipid-lowering properties that contribute to their beneficial cardiovascular effects.”
Roos, C. M., Zhang, B., Palmer, A. K., Ogrodnik, M. B., Pirtskhalava, T., Thalji, N. M., Hagler, M., Jurk, D., Smith, L. A., Casaclang‐Verzosa, G., et al. (2016) · Aging Cell · doi:10.1111/acel.12458 · Cited by 738 · see citing works
Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis
D’Agati, V. D., Chagnac, A., de Vries, A. P. J., Levi, M., Porrini, E., Herman‐Edelstein, M., & Praga, M. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.75 · Cited by 726 · see citing works
Molecular mechanisms of dietary restriction promoting health and longevity
Green, C. L., Lamming, D. W., & Fontana, L. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00411-4 · Cited by 714 · see citing works
Stamler, R. (1978) · JAMA · doi:10.1001/jama.240.15.1607 · Cited by 712 · see citing works
Hariharan, N., Maejima, Y., Nakae, J., Paik, J., DePinho, R. A., & Sadoshima, J. (2010) · Circulation Research · doi:10.1161/circresaha.110.227371 · Cited by 688 · see citing works
Fuster, J. J., Ouchi, N., Gokce, N., & Walsh, K. X. (2016) · Circulation Research · doi:10.1161/circresaha.115.306885 · Cited by 669 · see citing works
Variability of Body Weight and Health Outcomes in the Framingham Population
Lissner, L., Odell, P. M., D’Agostino, R. B., Stokes, J., Kreger, B. E., Belanger, A. J., & Brownell, K. D. (1991) · New England Journal of Medicine · doi:10.1056/nejm199106273242602 · Cited by 659 · see citing works
Targeting senescent cells alleviates obesity-induced metabolic dysfunction
Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang‐Verzosa, G., et al. (2019) · Aging Cell · doi:10.1111/acel.12950 · Cited by 658 · see citing works
Packer, M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.03.509 · Cited by 656 · cited 1× · see citing works
“184 A study involving monozygotic twins aged 23– 33 demonstrated that twins with obesity presented significantly higher levels of C-reactive protein, epicardial fat and cardiac hypertrophy than their lean siblings.”
Obesity, kidney dysfunction and hypertension: mechanistic links
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0145-4 · Cited by 654 · see citing works
Weight Loss and the Renin-Angiotensin-Aldosterone System
Engeli, S., Böhnke, J., Gorzelniak, K., Janke, J., Schling, P., Bäder, M., Luft, F. C., & Sharma, A. M. (2005) · Hypertension · doi:10.1161/01.hyp.0000154361.47683.d3 · Cited by 625 · see citing works
Bharath, L. P., Agrawal, M., McCambridge, G., Nicholas, D. A., Hasturk, H., Liu, J., Jiang, K., Liu, R., Guo, Z., Deeney, J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.015 · Cited by 614 · see citing works
Wang, X., Hu, Z., Hu, J., Du, J., & Mitch, W. E. (2006) · Endocrinology · doi:10.1210/en.2006-0251 · Cited by 600 · see citing works
Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-03421-7 · Cited by 588 · see citing works
Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity
Kim, F., Pham, M., Luttrell, I., Bannerman, D. D., Tupper, J., Thaler, J., Hawn, T. R., Raines, E. W., & Schwartz, M. W. (2007) · Circulation Research · doi:10.1161/circresaha.106.142851 · Cited by 584 · see citing works
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action
Ussher, J. R., & Drucker, D. J. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00849-3 · Cited by 577 · see citing works
Noyan-Ashraf, M. H., Momen, M. A., Ban, K., Sadi, A.-M., Zhou, Y.-Q., Riazi, A. M., Baggio, L. L., Henkelman, R. M., Husain, M., & Drucker, D. J. (2009) · Diabetes · doi:10.2337/db08-1193 · Cited by 575 · see citing works
The GH/IGF-1 axis in ageing and longevity
Junnila, R. K., List, E. O., Berryman, D. E., Murrey, J. W., & Kopchick, J. J. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.67 · Cited by 574 · see citing works
Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus
Shenouda, S. M., Widlansky, M. E., Chen, K., Xu, G., Holbrook, M., Tabit, C. E., Hamburg, N. M., Frame, A. A., Caiano, T. L., Kluge, M. A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.014506 · Cited by 570 · see citing works
Antelmi, I., De Paula, R. S., Shinzato, A. R., Peres, C. A., Mansur, A. J., & Grupi, C. J. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.09.065 · Cited by 555 · see citing works
Obesity paradox in patients with hypertension and coronary artery disease
Uretsky, S., Messerli, F. H., Bangalore, S., Champion, A., Cooper-DeHoff, R. M., Zhou, Q., & Pepine, C. J. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2007.05.011 · Cited by 550 · see citing works
Life expectancy after bariatric surgery in the Swedish obese subjects study
Carlsson, L. M. S., Sjöholm, K., Jacobson, P., Andersson-Assarsson, J. C., Svensson, P.-A., Taube, M., Carlsson, B., & Peltonen, M. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002449 · Cited by 509 · see citing works
Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation
Massiéra, F., Bloch-Faure, M., Ceiler, D. L., Murakami, K., Fukamizu, A., Gasc, J., Quignard‐Boulangé, A., Négrel, R., Ailhaud, G. P., Seydoux, J., et al. (2001) · The FASEB Journal · doi:10.1096/fj.01-0457fje · Cited by 505 · see citing works
Tong, M., Saito, T., Zhai, P., Oka, S.-I., Mizushima, W., Nakamura, M., Ikeda, S., Shirakabe, A., & Sadoshima, J. (2019) · Circulation Research · doi:10.1161/circresaha.118.314607 · Cited by 498 · see citing works
Disruption of the Ang II type 1 receptor promotes longevity in mice
Benigni, A., Corna, D., Zoja, C., Sonzogni, A., Latini, R., Salio, M., Conti, S., Rottoli, D., Longaretti, L., Cassis, P., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36703 · Cited by 486 · see citing works
Inflammatory processes in cardiovascular disease: a route to targeted therapies
Ruparelia, N., Chai, J. T., Fisher, E. A., & Choudhury, R. P. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.185 · Cited by 477 · see citing works
Inflammation, Aging, and Cardiovascular Disease
Liberale, L., Badimón, L., Montecucco, F., Lüscher, T. F., Libby, P., & Camici, G. G. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.017 · Cited by 472 · see citing works
Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan
Grosse, L., Wagner, N., Emelyanov, A., Molina, C., Lacas-Gervais, S., Wagner, K.-D., & Bulavin, D. V. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.05.002 · Cited by 460 · see citing works
Signaling pathways in obesity: mechanisms and therapeutic interventions
Wen, X., Zhang, B., Wu, B., Xiao, H., Li, Z., Li, R., Xu, X., & Li, T. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01149-x · Cited by 456 · see citing works
Obesity and the risk of cardiometabolic diseases
Valenzuela, P. L., Carrera-Bastos, P., Castillo-García, A., Lieberman, D. E., Santos-Lozano, A., & Lucia, A. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00847-5 · Cited by 452 · see citing works
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S.-I., et al. (2021) · Science · doi:10.1126/science.abe9985 · Cited by 439 · see citing works
Larsson, S. C., Bäck, M., Rees, J. M. B., Mason, A. M., & Burgess, S. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz388 · Cited by 436 · see citing works
Obesity and cognitive decline: role of inflammation and vascular changes
Nguyen, J. C. D., Killcross, S., & Jenkins, T. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00375 · Cited by 429 · see citing works
Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF
Deng, Y., Xie, M., Li, Q., Xu, X., Ou, W., Zhang, Y., Xiao, H., Yu, H., Zheng, Y., Liang, Y., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317933 · Cited by 413 · see citing works
de Jongh, R. T., Serné, E. H., IJzerman, R. G., de Vries, G., & Stehouwer, C. D. A. (2004) · Circulation · doi:10.1161/01.cir.0000129772.26647.6f · Cited by 407 · see citing works
Adiponectin, Leptin and Cardiovascular Disorders
Zhao, S., Kusminski, C. M., & Scherer, P. E. (2021) · Circulation Research · doi:10.1161/circresaha.120.314458 · Cited by 398 · see citing works
Picciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell · doi:10.1111/acel.12461 · Cited by 396 · see citing works
Long-term caloric restriction ameliorates the decline in diastolic function in humans
Meyer, T. E., Kovács, S. J., Ehsani, A. A., Klein, S., Holloszy, J. O., & Fontana, L. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.069 · Cited by 383 · see citing works
The role of sirtuins in cardiac disease
Matsushima, S., & Sadoshima, J. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00053.2015 · Cited by 378 · see citing works
Argentieri, M. A., Xiao, S., Bennett, D., Winchester, L. M., Nevado‐Holgado, A. J., Ghose, U., Albukhari, A., Yao, P., Mazidi, M., Lv, J., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03164-7 · Cited by 378 · see citing works
Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span
Grunewald, M., Kumar, S., Sharife, H., Volinsky, E., Gileles‐Hillel, A., Licht, T., Permyakova, A., Hinden, L., Azar, S., Friedmann, Y., et al. (2021) · Science · doi:10.1126/science.abc8479 · Cited by 370 · see citing works
Lopez-Jimenez, F., Almahmeed, W., Bays, H., Cuevas, A., Di Angelantonio, E., le Roux, C. W., Sattar, N., Sun, M. C., Wittert, G., Pinto, F. J., et al. (2022) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwac187 · Cited by 362 · see citing works
Effect of Obesity and Overweight on Left Ventricular Diastolic Function
Russo, C., Jin, Z., Homma, S., Rundek, T., Elkind, M. S. V., Sacco, R. L., & Di Tullio, M. R. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.042 · Cited by 361 · see citing works
Mitochondria as signaling organelles in the vascular endothelium
Quintero, M., Colombo, S. L., Godfrey, A. R., & Moncada, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601026103 · Cited by 358 · see citing works
Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease
Liberale, L., Montecucco, F., Tardif, J., Libby, P., & Camici, G. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz961 · Cited by 347 · see citing works
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice
Mitchell, S. J., Bernier, M., Aon, M. A., Cortassa, S., Kim, E. Y., Fang, E. F., Palacios, H. H., Ali, A., Navas-Enamorado, I., Di Francesco, A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.001 · Cited by 338 · see citing works
Boustany, C., Bharadwaj, K. G., Daugherty, A., Brown, D. R., Randall, D. C., & Cassis, L. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00265.2004 · Cited by 336 · see citing works
Dai, D., Karunadharma, P. P., Chiao, Y. A., Basisty, N., Crispin, D. A., Hsieh, E. J., Chen, T., Gu, H., Djukovic, D., Raftery, D., et al. (2014) · Aging Cell · doi:10.1111/acel.12203 · Cited by 328 · see citing works
A guide to understanding endoplasmic reticulum stress in metabolic disorders
Lemmer, I. L., Willemsen, N., Hilal, N., & Bartelt, A. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101169 · Cited by 319 · see citing works
Body Roundness Index and All-Cause Mortality Among US Adults
Zhang, X., Ma, N., Lin, Q., Chen, K., Zheng, F., Wu, J., Dong, X., & Niu, W. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.15051 · Cited by 319 · see citing works
Aged-senescent cells contribute to impaired heart regeneration
Lewis‐McDougall, F. C., Ruchaya, P. J., Domenjo‐Vila, E., Shin Teoh, T., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., et al. (2019) · Aging Cell · doi:10.1111/acel.12931 · Cited by 317 · see citing works
Empagliflozin after Acute Myocardial Infarction
Butler, J., Jones, W. S., Udell, J. A., Anker, S. D., Petrie, M. C., Harrington, J., Mattheus, M., Zwiener, I., Amir, O., Bahit, M. C., et al. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2314051 · Cited by 317 · see citing works
Obesity and cardiovascular disease: An ESC clinical consensus statement
Koskinas, K. C., Van Craenenbroeck, E. M., Antoniades, C., Blüher, M., Gorter, T. M., Hanssen, H., Marx, N., McDonagh, T. A., Mingrone, G., Rosengren, A., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae508 · Cited by 313 · see citing works
Body-Weight Fluctuations and Outcomes in Coronary Disease
Bangalore, S., Fayyad, R. S., Laskey, R. E., DeMicco, D. A., Messerli, F. H., & Waters, D. D. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1606148 · Cited by 309 · see citing works
Deanfield, J. E., Verma, S., Scirica, B. M., Kahn, S. E., Emerson, S. S., Ryan, D. H., Lingvay, I., Colhoun, H. M., Plutzky, J., Kosiborod, M., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01498-3 · Cited by 302 · see citing works
Sciarretta, S., Zhai, P., Shao, D., Maejima, Y., Robbins, J., Volpe, M., Condorelli, G., & Sadoshima, J. (2012) · Circulation · doi:10.1161/circulationaha.111.078212 · Cited by 292 · see citing works
Alpert, M. A., Lambert, C. R., Panayiotou, H., Terry, B. E., Cohen, M. V., Massey, C. V., Hashimi, M. W., & Mukerji, V. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80338-5 · Cited by 292 · see citing works
Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction
Hahn, V. S., Knutsdottir, H., Luo, X., Bedi, K., Margulies, K. B., Haldar, S. M., Stolina, M., Yin, J., Khakoo, A. Y., Vaishnav, J., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.050498 · Cited by 291 · see citing works
Tarantini, S., Valcarcel‐Ares, M. N., Tóth, P., Yabluchanskiy, A., Tucsek, Z., Kiss, T., Hertelendy, P., Kinter, M. T., Ballabh, P., Süle, Z., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101192 · Cited by 285 · see citing works
Hallmarks of cardiovascular ageing
Abdellatif, M., Rainer, P. P., Sedej, S., & Kroemer, G. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00881-3 · Cited by 285 · see citing works
Self-citationJonk, A. M., Houben, A. J. H. M., de Jongh, R. T., Serné, E. H., Schaper, N. C., & Stehouwer, C. D. A. (2007) · Physiology · doi:10.1152/physiol.00012.2007 · Cited by 279 · see citing works
Obesity is associated with increased arterial stiffness from adolescence until old age
Zebekakis, P. E., Nawrot, T. S., Thijs, L., Balkestein, E. J., Spek, J. J., Bortel, L. M. V., Struijker-Boudier, H. A. J., Safar, M. E., & Staessen, J. A. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000179511.93889.e9 · Cited by 276 · see citing works
NAD + Metabolism in Cardiac Health, Aging, and Disease
Abdellatif, M., Sedej, S., & Kroemer, G. (2021) · Circulation · doi:10.1161/circulationaha.121.056589 · Cited by 262 · see citing works
Self-citationUbiquitin Proteasome Dysfunction in Human Hypertrophic and Dilated Cardiomyopathies
Predmore, J. M., Wang, P., Davis, F. M., Bartolone, S. N., Westfall, M. V., Dyke, D. B. S., Pagani, F. D., Powell, S. R., & Day, S. M. (2010) · Circulation · doi:10.1161/circulationaha.109.904557 · Cited by 254 · see citing works
Essential role for premature senescence of myofibroblasts in myocardial fibrosis
Meyer, K., Hodwin, B., Ramanujam, D., Engelhardt, S., & Sarikas, A. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.02.047 · Cited by 247 · see citing works
CD36 Deficiency Rescues Lipotoxic Cardiomyopathy
Yang, J., Sambandam, N., Han, X., Gross, R. W., Courtois, M., Kovacs, A., Febbraio, M., Finck, B. N., & Kelly, D. P. (2007) · Circulation Research · doi:10.1161/01.res.0000264104.25265.b6 · Cited by 246 · see citing works
Cardiac Aging in Mice and Humans: The Role of Mitochondrial Oxidative Stress
Dai, D., & Rabinovitch, P. S. (2009) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2009.12.004 · Cited by 240 · see citing works
Autophagy in Cardiovascular Aging
Abdellatif, M., Sedej, S., Carmona-Gutierrez, D., Madeo, F., & Kroemer, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.312208 · Cited by 239 · see citing works
Self-citationAdipocyte Mitochondrial Function Is Reduced in Human Obesity Independent of Fat Cell Size
Yin, X. L., Lanza, I. R., Swain, J. M., Sarr, M. G., Nair, K. S., & Jensen, M. D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3042 · Cited by 226 · see citing works
Mone, P., Varzideh, F., Jankauskas, S. S., Pansini, A., Lombardi, A., Frullone, S., & Santulli, G. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19586 · Cited by 224 · see citing works
Withaar, C., Meems, L. M. G., Markousis-Mavrogenis, G., Boogerd, C. J., Silljé, H. H. W., Schouten, E. M., Dokter, M. M., Voors, A. A., Westenbrink, B. D., Lam, C. S. P., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa256 · Cited by 223 · see citing works
Grover, S. A., Kaouache, M., Rempel, P., Joseph, L., Dawes, M. G., Lau, D. C. W., & Lowensteyn, I. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70229-3 · Cited by 222 · see citing works
Obesity and Cardiac Remodeling in Adults: Mechanisms and Clinical Implications
Alpert, M. A., Karthikeyan, K., Abdullah, O., & Ghadban, R. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.012 · Cited by 221 · see citing works
Sawaki, D., Czibik, G., Pini, M., Ternacle, J., Suffee, N., Mercedes, R., Marcelin, G., Surénaud, M., Marcos, É., Gual, P., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.031358 · Cited by 217 · see citing works
Shao, D., Kolwicz, S. C., Wang, P., Roe, N. D., Villet, O. M., Nishi, K., Hsu, Y. A., Flint, G. V., Caudal, A., Wang, W., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.043319 · Cited by 217 · see citing works
Nicotinamide for the treatment of heart failure with preserved ejection fraction
Abdellatif, M., Trummer-Herbst, V., Koser, F., Durand, S., Adão, R., Vasques‐Nóvoa, F., Freundt, J. K., Voglhuber, J., Pricolo, M. R., Kasa, M., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd7064 · Cited by 215 · see citing works
Self-citationJensterle, M., Rizzo, M., Haluzík, M., & Janež, A. (2022) · Advances in Therapy · doi:10.1007/s12325-022-02153-x · Cited by 215 · see citing works
Aurigemma, G. P., SIMONE, G. D., & Fitzgibbons, T. P. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.111.964627 · Cited by 214 · see citing works
Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure
Zhou, B., Wang, D. D.-H., Qiu, Y., Airhart, S. E., Liu, Y., Stempien‐Otero, A., O’Brien, K. D., & Tian, R. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138538 · Cited by 212 · see citing works
Gevaert, A. B., Shakeri, H., Leloup, A. J., Van Hove, C. E., De Meyer, G. R. Y., Vrints, C. J., Lemmens, K., & Van Craenenbroeck, E. M. (2017) · Circulation: Heart Failure · doi:10.1161/circheartfailure.116.003806 · Cited by 211 · see citing works
Stritzke, J., Markus, M. R. P., Duderstadt, S., Lieb, W., Luchner, A., Döring, A., Keil, U., Hense, H., & Schunkert, H. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.07.034 · Cited by 205 · see citing works
Senescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial Infarction
Zhu, F., Li, Y., Zhang, J., Piao, C., Liu, T., Li, H.-H., & Du, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074535 · Cited by 201 · see citing works
Ciccone, M. M., Vettor, R., Pannacciulli, N., Minenna, A., Bellacicco, M., RIZZON, P., GIORGINO, R., & Pergola, G. D. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801623 · Cited by 195 · see citing works
Diet impact on mitochondrial bioenergetics and dynamics
Putti, R., Sica, R., Migliaccio, V., & Lionetti, L. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00109 · Cited by 192 · see citing works
Juonala, M., Kähönen, M. A. P., Laitinen, T. P., Hutri‐Kähönen, N., Jokinen, E., Taittonen, L. M., Pietikainen, M., Helenius, H. Y. M., Viikari, J. S. A., & Raitakari, O. T. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm556 · Cited by 190 · see citing works
Obesity and Weight Gain in Adulthood and Telomere Length
Kim, S., Parks, C. G., DeRoo, L. A., Chen, H., Taylor, J. A., Cawthon, R., & Sandler, D. P. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0935 · Cited by 190 · see citing works
Localization of fat depots and cardiovascular risk
Gruzdeva, O. V., Borodkinа, D. A., Учасова, Е. Г., Dyleva, Y. A., & Барбараш, О. Л. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0856-8 · Cited by 185 · see citing works
Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications
Xie, S., Xu, S., Deng, W., & Tang, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01378-8 · Cited by 185 · see citing works
Spermidine is essential for fasting-mediated autophagy and longevity
Hofer, S. J., Daskalaki, I., Bergmann, M., Friščić, J., Zimmermann, A., Mueller, M. I., Abdellatif, M., Nicastro, R., Masser, S., Durand, S., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01468-x · Cited by 183 · see citing works
Self-citationBarouch, L. A., Gao, D., Chen, L., Miller, K. L., Xu, W., Phan, A. C., Kittleson, M. M., Minhas, K. M., Berkowitz, D. E., Wei, C., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000199348.10580.1d · Cited by 180 · see citing works
Arterial Destiffening With Weight Loss in Overweight and Obese Middle-Aged and Older Adults
Dengo, A. L., Dennis, E. A., Orr, J. S., Marinik, E. L., Ehrlich, E., Davy, B. M., & Davy, K. P. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.147850 · Cited by 179 · see citing works
Wang, C.-Y., Kim, H.-H., Hiroi, Y., Sawada, N., Salomone, S., Benjamin, L. E., Walsh, K., Moskowitz, M. A., & Liao, J. K. (2009) · Science Signaling · doi:10.1126/scisignal.2000143 · Cited by 177 · see citing works
Muscle matters: The effects of medically induced weight loss on skeletal muscle
Prado, C. M., Phillips, S. M., Gonzalez, M. C., & Heymsfield, S. B. (2024) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00272-9 · Cited by 177 · see citing works
Xia, W., Veeragandham, P., Cao, Y., Xu, Y., Rhyne, T. E., Qian, J., Hung, C.-W., Zhao, P., Jones, Y., Gao, H., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00978-0 · Cited by 176 · see citing works
Obesity Induces Signs of Premature Cardiac Aging in Younger Patients
Niemann, B., Chen, Y., Teschner, M., Li, L., Silber, R., & Rohrbach, S. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.040 · Cited by 175 · see citing works
Correlation between age and weight loss after bariatric surgery
Contreras, J. E., Santander, C., Court, I., & Bravo, J. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0905-3 · Cited by 174 · see citing works
Shinmura, K., Tamaki, K., Sano, M., Murata, M., Yamakawa, H., Ishida, H., & Fukuda, K. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.10.018 · Cited by 173 · see citing works
Donato, A. J., Walker, A. E., Magerko, K. A., Bramwell, R. C., Black, A. D., Henson, G. D., Lawson, B. R., Lesniewski, L. A., & Seals, D. R. (2013) · Aging Cell · doi:10.1111/acel.12103 · Cited by 169 · see citing works
The benefits of GLP-1 drugs beyond obesity
Drucker, D. J. (2024) · Science · doi:10.1126/science.adn4128 · Cited by 169 · see citing works
Mice with hyper-long telomeres show less metabolic aging and longer lifespans
Muñoz-Lorente, M. A., Cano-Martin, A. C., & Blasco, M. A. (2019) · Nature Communications · doi:10.1038/s41467-019-12664-x · Cited by 168 · see citing works
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle
Yang, L., Licastro, D., Cava, E., Veronese, N., Spelta, F., Rizza, W., Bertozzi, B., Villareal, D. T., Hotamışlıgil, G. S., Holloszy, J. O., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.042 · Cited by 167 · see citing works
Schütten, M. T. J., Houben, A. J. H. M., de Leeuw, P. W., & Stehouwer, C. D. A. (2017) · Physiology · doi:10.1152/physiol.00037.2016 · Cited by 166 · see citing works
Obesity and Arterial Stiffness in Children
Coté, A. T., Phillips, A. A., Harris, K. C., Sandor, G. G. S., Panagiotopoulos, C., & Devlin, A. M. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.305062 · Cited by 161 · see citing works
Conley, S. M., Hickson, L. J., Kellogg, T. A., McKenzie, T. J., Heimbach, J. K., Taner, T., Tang, H. J., Jordan, K. L., Saadiq, I. M., Woollard, J. R., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00197 · Cited by 160 · see citing works
Zhou, Z., Macpherson, J., Gray, S. R., Gill, J. M. R., Welsh, P. I., Celis-Morales, C. A., Sattar, N. A., Pell, J. P., & Ho, F. K. W. (2021) · Diabetologia · doi:10.1007/s00125-021-05484-6 · Cited by 159 · see citing works
Ko, H. J., Zhang, Z., Jung, D. Y., Jun, J. Y., Ma, Z., Jones, K. E., Chan, S. Y., & Kim, J. K. (2009) · Diabetes · doi:10.2337/db08-1361 · Cited by 157 · see citing works
Jukarainen, S., Heinonen, S., Rämö, J. T., Rinnankoski‐Tuikka, R., Rappou, E., Tümmers, M., Muniandy, M., Hakkarainen, A., Lundbom, J., Lundbom, N. M. I., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3095 · Cited by 152 · see citing works
Mauro, C., Smith, J., Cucchi, D., Coe, D., Fu, H., Bonacina, F., Baragetti, A., Cermenati, G., Caruso, D., Mitro, N., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.01.008 · Cited by 149 · see citing works
Gavin, T. P., Stallings, H. W., Zwetsloot, K. A., Westerkamp, L. M., Ryan, N. A., Moore, R. A., Pofahl, W. E., & Hickner, R. C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00353.2004 · Cited by 148 · see citing works
Cardiometabolic multimorbidity and incident dementia: the Swedish twin registry
Dove, A. E., Guo, J., Marseglia, A., Fastbom, J., Vetrano, D. L., Fratiglioni, L., Pedersen, N. L., & Xu, W. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac744 · Cited by 147 · see citing works
SGLT2 inhibition eliminates senescent cells and alleviates pathological aging
Katsuumi, G., Shimizu, I., Suda, M., Yoshida, Y., Furihata, T., Joki, Y., Hsiao, C.-L., Liang, J., Fujiki, S., Abe, M., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00642-y · Cited by 145 · see citing works
Age‐Associated Changes in the Vascular Renin‐Angiotensin System in Mice
Yoon, H. E., Kim, E. N., Kim, M. Y., Lim, J. H., Jang, I. E., Ban, T. H., Shin, S. J., Park, C. W., Chang, Y. S., & Choi, B. S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6731093 · Cited by 143 · see citing works
Obesity paradox in elderly patients with cardiovascular diseases
Dorner, T. E., & Rieder, A. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.01.076 · Cited by 139 · see citing works
The blessings and curses of C57BL/6 substrains in mouse genetic studies
Bryant, C. D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06325.x · Cited by 139 · see citing works
Birks, E. J., Latif, N., Enesa, K., Folkvang, T., Luong, L. A., Sarathchandra, P., Khan, M., Ovaa, H., Terracciano, C. M., Barton, P. J. R., et al. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn083 · Cited by 139 · see citing works
Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes
Fukushima, A., & Lopaschuk, G. D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.03.020 · Cited by 139 · see citing works
Weight Change, Weight Fluctuation, and Mortality
Wannamethee, S. G., Shaper, A. G., & Walker, M. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.22.2575 · Cited by 134 · see citing works
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
Valentine, J. M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M. P., Gao, H., Yu, R. T., Liddle, C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci153357 · Cited by 134 · see citing works
Sampath, H., Vartanian, V. L., Rollins, M. R., Sakumi, K., Nakabeppu, Y., & Lloyd, R. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051697 · Cited by 132 · see citing works
Gruberg, L., Mercado, N. F., Milo, S., Boersma, E. H., Disco, C. M. C., van Es, G., Lemos, P. A., Bentzvi, M., Wijns, W. C., Unger, F., et al. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.10.007 · Cited by 131 · see citing works
Canagliflozin extends life span in genetically heterogeneous male but not female mice
Miller, R. A., Harrison, D. E., Allison, D. B., Bogue, M. A., Debarba, L. K., Diaz, V., Fernández, E., Gałecki, A. T., Garvey, W. T., Jayarathne, H. S. M., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.140019 · Cited by 126 · see citing works
RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression
Martínez, P., Goméz-López, G., Garcı́a, F., Mercken, E. M., Mitchell, S. J., Flores, J. M., de Cabo, R., & Blasco, M. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.030 · Cited by 125 · see citing works
Predisposing factors for atrial fibrillation in the elderly.
Wasmer, K., Eckardt, L., & BREITHARDT, G. E. (2017) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2017.03.010 · Cited by 125 · see citing works
Osto, E., Doytcheva, P., Corteville, C., Bueter, M., Dörig, C., Stivala, S., Buhmann, H., Colin, S., Rohrer, L., Hasballa, R., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.011791 · Cited by 125 · see citing works
A nutritional memory effect counteracts the benefits of dietary restriction in old mice
Hahn, O., Drews, L. F., Nguyen, A., Tatsuta, T., Gkioni, L., Hendrich, O., Zhang, Q., Langer, T., Pletcher, S. D., Wakelam, M. J. O., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0121-0 · Cited by 118 · see citing works
Increased cell senescence in human metabolic disorders
Spinelli, R., Baboota, R. K., Gogg, S., Bèguinot, F., Blüher, M., Nerstedt, A., & Smith, U. (2023) · Journal of Clinical Investigation · doi:10.1172/jci169922 · Cited by 117 · see citing works
Harrison, D. E., Strong, R., Reifsnyder, P. C., Kumar, N., Fernández, E., Flurkey, K., Javors, M. A., Lopez‐Cruzan, M., Macchiarini, F., Nelson, J. F., et al. (2021) · Aging Cell · doi:10.1111/acel.13328 · Cited by 114 · see citing works
Hoong, C. W. S., & Chua, M. W. J. (2021) · Endocrinology · doi:10.1210/endocr/bqab079 · Cited by 112 · see citing works
Giugliano, D., Longo, M., Scappaticcio, L., Bellastella, G., Maiorino, M. I., & Esposito, K. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01430-3 · Cited by 111 · see citing works
Lee, G., Kim, Y. Y., Jang, H., Han, J. S., Nahmgoong, H., Park, Y. J., Han, S. M., Cho, C., Lim, S., Noh, J.-R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.03.010 · Cited by 111 · see citing works
Fernández, Á. F., Bárcena, C., Martínez-García, G. G., Tamargo-Gómez, I., Suárez, M. F., Pietrocola, F., Castoldi, F., Esteban, L., Sierra-Filardi, E., Boya, P., et al. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.373 · Cited by 109 · see citing works
Self-citationCaloric restriction may reverse age‐related autonomic decline in humans
Stein, P. K., Soare, A., Meyer, T. E., Cangemi, R., Holloszy, J. O., & Fontana, L. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00825.x · Cited by 108 · see citing works
Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity
Abdellatif, M., Trummer-Herbst, V., Heberle, A. M., Humnig, A., Pendl, T., Durand, S., Cerrato, G., Hofer, S. J., Islam, M., Voglhuber, J., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.059863 · Cited by 108 · see citing works
Self-citationInsulin receptor substrate signaling controls cardiac energy metabolism and heart failure
Guo, C., & Guo, S. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0679 · Cited by 107 · see citing works
Ferdinand, K. C., Izzo, J. L., Lee, J., Meng, L., George, J. T., Salsali, A., & SEMAN, L. J. (2019) · Circulation · doi:10.1161/circulationaha.118.036568 · Cited by 107 · see citing works
Kizhakekuttu, T. J., Wang, J., Dharmashankar, K., Ying, R., Gutterman, D. D., Vita, J. A., & Widlansky, M. E. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.256024 · Cited by 104 · see citing works
Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity
López-Lluch, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.005 · Cited by 103 · cited 1× · see citing works
“116 Mitochondrial fragmentation, which is evident both in mice and humans, 117,118 is mediated by the small GTPase RalA.”
SGLT inhibitors on weight and body mass: A meta‐analysis of 116 randomized‐controlled trials
Cheong, A. J. Y., Teo, Y. N., Teo, Y. H., Syn, N. L. X., Ong, H. T., Ting, A. Z. H., Chia, A. Z. Q., Chong, E. Y., Chan, M. Y., Lee, C., et al. (2021) · Obesity · doi:10.1002/oby.23331 · Cited by 102 · see citing works
Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice
Ock, S., Lee, W. S., Ahn, J., Kim, H. M., Kang, H., Kim, H.-S., Jo, D., Abel, E. D., Lee, T. J., & Kim, J. (2015) · Endocrinology · doi:10.1210/en.2015-1709 · Cited by 101 · see citing works
Obesogenic high fat western diet induces oxidative stress and apoptosis in rat heart
Ballal, K., Wilson, C. R., Harmancey, R., & Taegtmeyer, H. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0546-y · Cited by 100 · see citing works
GLP-1 receptor agonists effect on cognitive function in patients with and without type 2 diabetes
Monney, M., Jornayvaz, F. R., & Gariani, K. (2023) · Diabetes & Metabolism · doi:10.1016/j.diabet.2023.101470 · Cited by 99 · see citing works
The Effects of Obesity on the Cerebral Vasculature
Dorrance, A. M., Matin, N., & Pires, P. W. (2014) · Current Vascular Pharmacology · doi:10.2174/1570161112666140423222411 · Cited by 98 · see citing works
Packer, M. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1732 · Cited by 97 · see citing works
Rouault, C., Marcelin, G., Adriouch, S., Rose, C., Genser, L., Ambrosini, M., Bichet, J.-C., Zhang, Y., Marquet, F., Aron-Wisnewsky, J., et al. (2021) · Diabetologia · doi:10.1007/s00125-020-05307-0 · Cited by 95 · see citing works
de Kloet, A. D., Krause, E. G., Kim, D.-H., Sakai, R. R., Seeley, R. J., & Woods, S. C. (2009) · Endocrinology · doi:10.1210/en.2009-0065 · Cited by 93 · see citing works
Wu, M., Yu, X., Xu, L., Wu, S., & Tian, Y. (2022) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab412 · Cited by 93 · see citing works
SIRT1 Regulation in Ageing and Obesity
Pardo, P. S., & Boriek, A. M. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111249 · Cited by 90 · see citing works
Higher Body Mass Index in Adolescence Predicts Cardiomyopathy Risk in Midlife
Robertson, J., Schaufelberger, M., Lindgren, M., Adiels, M., Schiöler, L., Torén, K., McMurray, J. J. V., Sattar, N. A., Åberg, M., & Rosengren, A. (2019) · Circulation · doi:10.1161/circulationaha.118.039132 · Cited by 89 · see citing works
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
Valentine, J. M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M. P., Gao, H., Yu, R. T., Liddle, C., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 89 · see citing works
Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction
Wang, D. D., Airhart, S. E., Zhou, B., Shireman, L. M., Jiang, S., Rodriguez, C. M., Kirkpatrick, J. N., Shen, D. D., Tian, R., & O’Brien, K. D. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.06.012 · Cited by 89 · see citing works
Badimón, L., Bugiardini, R., Cenko, E., Cubedo, J., Dorobanţu, M., Duncker, D. J., Estruch, R., Miličić, D., Tousoulis, D., Vasiljević, Z., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx181 · Cited by 88 · see citing works
Systemic inflammation and biological aging in the Health and Retirement Study
Meier, H. C. S., Mitchell, C. M., Karadimas, T., & Faul, J. D. (2023) · GeroScience · doi:10.1007/s11357-023-00880-9 · Cited by 88 · see citing works
Obesity cardiomyopathy: diagnosis and therapeutic implications
Wong, C. Y., & Marwick, T. H. (2007) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0964 · Cited by 87 · see citing works
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Ganamurali, N., & Sabarathinam, S. (2026) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.70001 · Cited by 8 · see citing works
- Authors
- Ruperez, C., Madeo, F., de Cabo, R., Kroemer, G., & Abdellatif, M.
- Affiliations
- Department of Cardiology, Medical University of Graz , Auenbruggerplatz 15, Graz 8036 ,
- University of Graz (AT)
- Translational Gerontology Branch, National Institute on Aging , Baltimore, MD ,
- Inserm (FR)
- Corresponding author
- Kroemer, Guido
- Abdellatif, Mahmoud
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2025-04-08
- Volume
- 46
- Issue
- 23
- Pages
- 2161-2185
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- PMC
- PMC12167665
- OpenAlex
- W4409261750
- Cited by
- 73
- References
- 295
- Citations by year
- 2026: 53 · 2025: 20
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Heart Journal (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc)
- Funders
- Medical University of Graz
- BioTechMed-Graz
- Austrian Science Fund
- European Commission
- FWF
- ANR
- Agence National de la Recherche (ANR-22-CE14-0066, ANR-23-CE44-0030, ANR-23-R4HC-0006)
- Association pour la recherche sur le cancer
- Cancéropôle Ile-de-France
- Fondation pour la Recherche Médicale
- European Joint Programme on Rare Diseases
- European Research Council Advanced Investigator Award (101052444)
- European Union Horizon 2020 research and innovation programmes Oncobiome (825410)
- Prevalung (101095604)
- Neutrocure (861878)
- Hevolution Network on Senescence in Aging
- Institut National du Cancer
- Institut Universitaire de France
- Mark Foundation
- PAIR-Obésité INCa_1873
- LUCA-pi (ANR-21-RHUS-0017, ANR-23-RHUS-0010)
- Seerave Foundation
- SIRIC Cancer Research and Personalized Medicine
- Ministère des Solidarités et de la Santé
- INSERM
- University of Graz
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, cardiovascular aging, cardiovascular disease, weight loss, lifespan extension, metabolic intervention, cardiovascular therapeutics, older adults
- MeSH terms
- Aging, Animals, Cardiovascular Diseases, Humans, Obesity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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