The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems: A Clinical Review
Abstract
IMPORTANCE: As of March 2015, 23 states and the District of Columbia had medical marijuana laws in place. Physicians should know both the scientific rationale and the practical implications for medical marijuana laws. OBJECTIVE: To review the pharmacology, indications, and laws related to medical marijuana use. EVIDENCE REVIEW: The medical literature on medical marijuana was reviewed from 1948 to March 2015 via MEDLINE with an emphasis on 28 randomized clinical trials of cannabinoids as pharmacotherapy for indications other than those for which there are 2 US Food and Drug Administration-approved cannabinoids (dronabinol and nabilone), which include nausea and vomiting associated with chemotherapy and appetite stimulation in wasting illnesses. FINDINGS: Use of marijuana for chronic pain, neuropathic pain, and spasticity due to multiple sclerosis is supported by high-quality evidence. Six trials that included 325 patients examined chronic pain, 6 trials that included 396 patients investigated neuropathic pain, and 12 trials that included 1600 patients focused on multiple sclerosis. Several of these trials had positive results, suggesting that marijuana or cannabinoids may be efficacious for these indications. CONCLUSIONS AND RELEVANCE: Medical marijuana is used to treat a host of indications, a few of which have evidence to support treatment with marijuana and many that do not. Physicians should educate patients about medical marijuana to ensure that it is used appropriately and that patients will benefit from its use.
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Cites
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Burke, N. N., Finn, D. P., McGuire, B. E., & Roche, M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23802 · Cited by 268
Cannabis and mental illness: a review
Lowe, D. J. E., Sasiadek, J. D., Coles, A. S., & George, T. P. (2019) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-018-0970-7 · Cited by 253
Cannabis as a substitute for prescription drugs – a cross-sectional study
Corroon, J., Mischley, L., & Sexton, M. (2017) · Journal of Pain Research · doi:10.2147/jpr.s134330 · Cited by 208
Evaluation of hemp (Cannabis sativa L.) as an industrial crop: a review
Rehman, M., Fahad, S., Du, G., Cheng, X., Yang, Y., Tang, K., Liu, L., Liu, F.-H., & Deng, G. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16264-5 · Cited by 199
Metadata
- Authors
- Hill, K. P.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2015-06-23
- Volume
- 313
- Issue
- 24
- Pages
- 2474
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2112074033
- Cited by
- 508
- References
- 63
- FWCI
- 36.80
- Type
- journal article
- Language
- en
- Open access
- closed
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