Psychological stress in early life as a predisposing factor for the development of chronic pain: clinical and preclinical evidence and neurobiological mechanisms

Burke, Nikita N.; Finn, David P.; McGuire, Brian E.; Roche, Michelle

doi:10.1002/jnr.23802

Cited by 268Pain Mechanisms and TreatmentsStress Responses and CortisolChild Abuse and Trauma

Psychological stress in early life as a predisposing factor for the development of chronic pain: clinical and preclinical evidence and neurobiological mechanisms

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Burke, Nikita N., Finn, David P., McGuire, Brian E., Roche, Michelle·2017·Journal of Neuroscience Research

DOI 10.1002/jnr.23802

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Abstract

A wealth of research over the past 2 decades has expanded our understanding of the impact of early‐life adversity on physiological function and, consequently, health and wellbeing in later life. Early‐life adversity increases the risk of developing a number of disorders, such as chronic pain, fibromyalgia, and irritable bowel syndrome. Although much of the research has examined the impact of physical maltreatment, an increasing number of studies have been published over the past few years examining the effect of childhood psychological stress and trauma on the development of various types of chronic pain conditions. We review the clinical and preclinical data examining the link among early‐life psychological stress, altered nociceptive behavior, and chronic pain in later life. Evidence supporting a role for certain key neurobiological substrates, including the hypothalamic‐pituitary‐adrenal axis; monoaminergic, opioidergic, endocannabinoid and immune systems; and epigenetic mechanisms in the association between early‐life psychological stress and chronic pain, is provided. Greater understanding of the impact of early‐life stress may inform the development of personalized treatments for chronic pain in later life and strategies to prevent its onset in susceptible individuals. © 2016 Wiley Periodicals, Inc.

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Depression, anxiety, and emotional distress contribute strongly, often more strongly than pain intensity, to long-term persistent pain outcomes including physical disability, work disability, healthcare costs, mortality, and suicide.
“there is a wealth of evidence that symptoms of depression, anxiety, and emotional distress contribute strongly (more strongly than pain intensity, in many studies) to key long-term outcomes of persistent pain such as physical disability 35, 43–46, work disability 47, healthcare costs 48, 49, mortality 50–53, and suicide 22, 54, 55.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [49]
Physiological alterations associated with ELAb may contribute to the development of stress-related functional pain syndromes and affective impairment in adulthood, both of which predominately affect women.
“As such, physiological alterations associated with ELAb may contribute to the development of stress-related functional pain syndromes,(17) and affective impairment in adulthood,(20,21) both of which predominately affect women.(22,23)”
From Effects of Mindfulness-Based Stress Reduction on Experimental Pain Sensitivity and Cortisol Responses in Women with Early Life Abuse: A Randomized Controlled Trial (2021) · cites this paper as [17]
Dysregulation of allostatic systems can manifest as either hypo- or hyper-responsiveness to stress later in life, with consequent impairment in endogenous pain regulation.
“However, dysregulation of allostatic systems can manifest as either hypo- or hyper- responsiveness to stress later in life,(14–16) with consequent impairment in endogenous pain regulation.(17–19)”
From Effects of Mindfulness-Based Stress Reduction on Experimental Pain Sensitivity and Cortisol Responses in Women with Early Life Abuse: A Randomized Controlled Trial (2021) · cites this paper as [17]
The blunted cortisol-AUC observed at baseline in those with ELAb may explain, in part, why women with ELAb are at risk for pain disorders.
“and may explain, in part, why women with ELAb are at risk for pain disorders.(17,19)”
From Effects of Mindfulness-Based Stress Reduction on Experimental Pain Sensitivity and Cortisol Responses in Women with Early Life Abuse: A Randomized Controlled Trial (2021) · cites this paper as [17]

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GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease
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A Systematic Review of the Prospective Relationship between Child Maltreatment and Chronic Pain
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C-Reactive Protein (CRP) is Associated With Chronic Pain Independently of Biopsychosocial Factors
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Higher levels of stress and different coping strategies are associated with greater morning and evening fatigue severity in oncology patients receiving chemotherapy
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Functional imaging correlates of childhood trauma: A qualitative review of past research and emerging trends
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Racism as a Source of Pain
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Exogenous microbiota-derived metabolite trimethylamine N-oxide treatment alters social behaviors: Involvement of hippocampal metabolic adaptation
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Studies on irritable bowel syndrome associated with anxiety or depression in the last 20 years: A bibliometric analysis
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Early Life Stress and Major Depressive Disorder—An Update on Molecular Mechanisms and Synaptic Impairments
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Early-life programming of pain sensation? Spinal pain in pre-adolescents with pain experience in early life
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Psychosocial factors associated with poor outcomes after amputation for complex regional pain syndrome type-I
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Understanding the Pain Experience and Treatment Considerations Along the Spectrum of Peripheral Artery Disease: A Scientific Statement From the American Heart Association
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A Systematic Review of the Prospective Relationship Between Bullying Victimization and Pain
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Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine
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Nociceptor Overexpression of NaV1.7 Contributes to Chronic Muscle Pain Induced by Early-Life Stress
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A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain
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A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration
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Hassles predict physical health complaints in undergraduate students: a dynamic structural equation model analysis of daily diary data
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Non-invasive monitoring of stress biomarkers in the newborn period
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Central Nervous System Changes in Pelvic Inflammation/Pain Patients
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Chronic Primary Pain of the Spine: an Integrative Perspective Part 1
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The association between adverse childhood experiences, self-silencing behaviours and symptoms in women with fibromyalgia
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Early-life adversity increases morphine tolerance and persistent inflammatory hypersensitivity through upregulation of δ opioid receptors in mice
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Psychological, social and biological correlates of body perception disturbance in complex regional pain syndrome
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The Development of Adolescent Chronic Pain following Traumatic Brain Injury and Surgery: The Role of Diet and Early Life Stress
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ASSOCIATION OF DEPRESSION IN PATIENTS WITH FIBROMYALGIA SYNDROME
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The Clinical Utility of a Brief Psychological Stress Measure (Patient-Reported Outcomes Measurement Information System) in Youth with Chronic Pain
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The effect of early burn injury on sensitivity to future painful stimuli in dairy heifers
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A high-fat high-sugar diet and adversity early in life modulate pain outcomes at the behavioural and molecular level in adolescent rats: The role of sex
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Authors: Burke, N. N., Finn, D. P., McGuire, B. E., & Roche, M.
Affiliations: Ollscoil na Gaillimhe – University of Galway (IE)
Corresponding author: Roche, Michelle
ORCID: Burke, Nikita N.
Finn, David P.
McGuire, Brian E.
Roche, Michelle
Venue: Journal of Neuroscience Research
Publisher: Wiley
Published: 2016-07-12
Volume: 95
Issue: 6
Pages: 1257-1270
ISSN: 0360-4012 (ISSN-L)
1097-4547
DOI: 10.1002/jnr.23802
OpenAlex: W2482083953
Cited by: 268
References: 157
Citations by year: 2026: 27 · 2025: 24 · 2024: 27 · 2023: 39 · 2022: 33 · 2021: 27 · 2020: 31 · 2019: 35 · 2018: 14 · 2017: 10 · 2016: 1
FWCI: 2.35
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
University of Galway Research Repository (submittedVersion, cc-by)
Funders: Science Foundation Ireland (#11/RFP/NES/3175, 10/IN.1/B2976)
Topics: Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: chronic pain, childhood trauma, childhood adversity, nociception, hypothalamic-pituitary-adrenal axis, monoaminergic systems, opioid system, endocannabinoid system, immune system, epigenetics, fibromyalgia, irritable bowel syndrome, pain prevention, personalized pain treatment
MeSH terms: Animals, Child, Humans, Neurobiology, Stress, Psychological, Causality, Adult Survivors of Child Abuse, Translational Research, Biomedical, Chronic Pain

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Psychological stress in early life as a predisposing factor for the development of chronic pain: clinical and preclinical evidence and neurobiological mechanisms

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