Tinnitus

Prevalence, Severity, Exposures, and Treatment Patterns of Tinnitus in the United States

Bhatt, J. M., Lin, H. W., & Bhattacharyya, N. (2016) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2016.1700 · Cited by 460 · see citing works

A systematic review and meta-analysis of randomized controlled trials of cognitive-behavioral therapy for tinnitus distress

Hesser, H., Weise, C., Westin, V. Z., & Andersson, G. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.12.006 · Cited by 340 · see citing works

Using resting state functional connectivity to unravel networks of tinnitus

Husain, F. T., & Schmidt, S. A. (2013) · Hearing Research · doi:10.1016/j.heares.2013.07.010 · Cited by 214 · see citing works

Role of attention in the generation and modulation of tinnitus

Roberts, L. E., Husain, F. T., & Eggermont, J. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.007 · Cited by 202 · see citing works

Acceptance and Commitment Therapy versus Tinnitus Retraining Therapy in the treatment of tinnitus: A randomised controlled trial

Westin, V. Z., Schulin, M., Hesser, H., Karlsson, M., Noe, R. Z., Olofsson, U., Stalby, M., Wisung, G., & Andersson, G. (2011) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.08.001 · Cited by 168 · see citing works

Effect of Tinnitus Retraining Therapy vs Standard of Care on Tinnitus-Related Quality of Life

Scherer, R. W., & Formby, C. (2019) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2019.0821 · Cited by 95 · see citing works

Effectiveness of Guided Internet-Based Cognitive Behavioral Therapy vs Face-to-Face Clinical Care for Treatment of Tinnitus

Beukes, E. W., Andersson, G., Allen, P. M., Manchaiah, V. K. C., & Baguley, D. (2018) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2018.2238 · Cited by 88 · see citing works

S3 Guideline: Chronic Tinnitus

Mazurek, B., Hesse, G., Sattel, H. C., Kratzsch, V., Lahmann, C., & Dobel, C. (2022) · HNO · doi:10.1007/s00106-022-01207-4 · Cited by 67 · see citing works

The Comorbidity of Depression and Anxiety Symptoms in Tinnitus Sufferers: A Network Analysis

Chen, X., Ren, L., Xue, X., Yu, N., Liu, P., Shen, W., Zhou, H., Wang, B., Zhou, J., Yang, S., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13040583 · Cited by 29 · see citing works

Topological features of limbic dysfunction in chronicity of tinnitus with intact hearing: New hypothesis for ‘noise-cancellation’ mechanism

Lan, L., Chen, Y., Shang, S., Lu, L., Xǔ, J., Yin, X., Wu, Y., & Cai, Y. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110459 · Cited by 28 · see citing works

Worldwide Tinnitus Research: A Bibliometric Analysis of the Published Literature Between 2001 and 2020

Zhou, F.-W., Zhang, T., Jin, Y., Ma, Y., Xian, Z., Zeng, M., & Yu, G.-D. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.828299 · Cited by 29 · see citing works

Specific brain network predictors of interventions with different mechanisms for tinnitus patients

Lan, L., Liu, Y., Wu, Y., Xu, Z.-G., Xǔ, J., Song, J., Salvi, R., Yin, X., Chen, Y., & Cai, Y. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103862 · Cited by 25 · see citing works

Tinnitus Neuroimaging

Adams, M. E., Huang, T. C., Nagarajan, S. S., & Cheung, S. W. (2020) · Otolaryngologic Clinics of North America · doi:10.1016/j.otc.2020.04.002 · Cited by 23 · see citing works

Vulnerability to chronic stress and the phenotypic heterogeneity of presbycusis with subjective tinnitus

Ruan, J., Hu, X., Liu, Y., Han, Z., & Ruan, Q. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1046095 · Cited by 19 · see citing works

Efficacy of Tailor-Made Notched Music Training Versus Tinnitus Retraining Therapy in Adults With Chronic Subjective Tinnitus: A Randomized Controlled Clinical Trial

Tong, Z., Deng, W., Huang, X., Dong, H., Li, J., Zhao, F., Chen, G., Zhou, X., Li, H., Lan, L., et al. (2023) · Ear & Hearing · doi:10.1097/aud.0000000000001318 · Cited by 19 · see citing works

Explainable AI Method for Tinnitus Diagnosis via Neighbor-Augmented Knowledge Graph and Traditional Chinese Medicine: Development and Validation Study

Yin, Z., Kuang, Z., Zhang, H., Guo, Y., Li, T., Wu, Z., & Wang, L. (2024) · JMIR Medical Informatics · doi:10.2196/57678 · Cited by 14 · see citing works

Clinical characteristics and psychoacoustic analysis of acute and chronic subjective tinnitus

Zhang, H., Ji, L., Wang, L., Yin, Z., Cen, J., & Guo, Y. (2023) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.1037 · Cited by 11 · see citing works

Characteristic alterations of gut microbiota and serum metabolites in patients with chronic tinnitus: a multi-omics analysis

Wang, J., Xiang, J.-H., Peng, X.-Y., Liu, M., Sun, L., Zhang, M., Zhang, L.-Y., Chen, Z., Tang, Z., & Cheng, L. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01878-24 · Cited by 12 · see citing works

Tinnitus classification based on resting-state functional connectivity using a convolutional neural network architecture

Xu, Q., Zhou, L., Xing, C., Xu, X., Feng, Y., Lv, H., Zhao, F., Chen, Y., & Cai, Y. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120566 · Cited by 10 · see citing works

Cross-sectional screening for inflammation in tinnitus with near-normal hearing

Mennink, L. M., Albakri, L. B. M., Aalbers, M. W., van Dijk, P., & van Dijk, J. M. C. (2024) · Hearing Research · doi:10.1016/j.heares.2024.109124 · Cited by 9 · see citing works

Prediction of treatment outcome in patients suffering from chronic tinnitus – from individual characteristics to early and long-term change

Ivanšić, D., Palm, J., Pantev, C., Brüeggemann, P., Mazurek, B., Guntinas‐Lichius, O., & Dobel, C. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.110794 · Cited by 9 · see citing works

Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus

Fuksa, J., Profant, O., Tintěra, J., Svobodová, V., Tóthová, D., Škoch, A., & Syka, J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.921873 · Cited by 9 · see citing works

Neuroprotection Role of Vitamin C by Upregulating Glutamate Transporter-1 in Auditory Cortex of Noise-Induced Tinnitus Animal Model

Cao, W., Xiong, S., Ji, W., Wei, H., Ma, F., & Mao, L. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00765 · Cited by 7 · see citing works

Predictors of Response to Cognitive Behavioral Therapy in Patients With Tinnitus

Mueller, L. E., Kallogjeri, D., Frumkin, M. R., Dizdar, K., Shin, J., Rodebaugh, T. L., & Piccirillo, J. F. (2024) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2024.2264 · Cited by 6 · see citing works

The Alteration of Brain Network Topology in Tinnitus Transition From Recent‐Onset to Chronic

Xie, J., Zhang, W., Wei, W., Bai, Y., Shen, Y. M., Meng, N., Wang, X., & Wang, M. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.16664 · Cited by 6 · see citing works

SoundMind Trial: a study protocol for a randomised controlled trial for online acceptance and commitment therapy and sound therapy for tinnitus

Huang, X., Tang, D., Sun, S., & Li, H. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-080863 · Cited by 3 · see citing works

Involvement of BK Channels and Ryanodine Receptors in Salicylate-induced Tinnitus

Shi, W., Zhao, Q., Gao, H., Yang, C., Tan, Z., Li, N., Jiang, F., Wang, H., Ji, Y., & Zhou, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04533-6 · Cited by 4 · see citing works

Efficacy of Nortriptyline-Topiramate and Verapamil-Paroxetine in Tinnitus Management: A Randomized Placebo-Controlled Trial

Abouzari, M., Tawk, K., Kim, J. K., Larson, E., Lin, H. W., & Djalilian, H. R. (2024) · Otolaryngology Head & Neck Surgery · doi:10.1002/ohn.1063 · Cited by 5 · see citing works

Effect of tinnitus on sound localization ability in patients with normal hearing

Long, Y., Wang, W., Liu, J., Liu, K., & Gong, S. (2023) · Brazilian Journal of Otorhinolaryngology · doi:10.1016/j.bjorl.2023.01.003 · Cited by 4 · see citing works

Personalized Therapy of Neurological Disorders

Jain, K. K. (2020) · Springer eBooks · doi:10.1007/978-3-030-62080-6_11 · Cited by 4 · see citing works

The role of tinnitus distress in the development of somatization symptoms among patients: implications for health care in Pakistan

Ahmed, A., & Aslam, N. (2022) · International Journal of Human Rights in Healthcare · doi:10.1108/ijhrh-09-2021-0183 · Cited by 4 · see citing works

Hearing loss and tinnitus: association with employment and income among young adults

Jacobs, M., Tobener, E., & Ellis, C. (2025) · Frontiers in Audiology and Otology · doi:10.3389/fauot.2025.1595281 · Cited by 3 · see citing works

Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus

Lan, L., Liu, Y., Xǔ, J., Ma, D., Yin, X., Wu, Y., Chen, Y., & Cai, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.913191 · Cited by 3 · see citing works

Development of a Prognostic Nomogram for Modified Tinnitus Relieving Sound Therapy for Subjective Tinnitus

Gu, D., Wu, L., & Tang, D. (2023) · Otolaryngology · doi:10.1002/ohn.611 · Cited by 3 · see citing works

Neural mechanisms of tinnitus: An exploration from the perspective of varying severity levels

Xie, J., Zhang, W., Bai, Y., Wei, W., Shen, Y. M., Li, W., Wang, X., Yu, C., Pan, J., Jia, X., et al. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111250 · Cited by 3 · see citing works

A triple blind, placebo controlled, randomised controlled trial of betahistine dihydrochloride in the treatment of primary tinnitus

Castilho, G. L., Dias, N. H., & Martins, R. H. G. (2022) · Clinical Otolaryngology · doi:10.1111/coa.13999 · Cited by 3 · see citing works

Noninvasive Treatment of Venous Pulsatile Tinnitus with an Internal Jugular Vein Compression Collar

Succop, B. S., Thompson, N. J., Dedmon, M. M., Gelinne, A., Selleck, A., Reed, S., & Sindelar, M. B. D. (2024) · The Laryngoscope · doi:10.1002/lary.31326 · Cited by 3 · see citing works

Integrating pharmacogenomics into clinical trials of hearing disorders

Brutnell, T. P., Wang, X., & Bao, J. (2022) · The Journal of the Acoustical Society of America · doi:10.1121/10.0015092 · Cited by 3 · see citing works

Pharmacological Treatments for Tinnitus

Asnis, G. M. (2020) · JAMA · doi:10.1001/jama.2020.11851 · Cited by 3 · see citing works

Research trends and hotspots of cognitive behavioral therapy for tinnitus: a bibliometric analysis

He, Y., Liu, J., Cheng, H., Ye, H., Li, C., Gao, Y., & Xu, X. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1536224 · Cited by 2 · see citing works

Interactive effect of hemodynamics in transverse sigmoid sinus and bone morphology on venous pulsatile tinnitus: a four-dimensional (4D) flow magnetic resonance imaging (MRI) study

Lv, K., Zheng, S., Wang, H., Zhao, C., Yu, Z., Shen, Z., Xu, K., Chai, C., & Xia, S. (2024) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-24-610 · Cited by 2 · see citing works

Arterial Spin Labeling Cerebral Perfusion Changes in Chronic Tinnitus With Tension-Type Headache

Xu, Z.-G., Xǔ, J., Hu, J.-H., Wu, Y., & Wang, D. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.698539 · Cited by 2 · see citing works

Activation of the Gamma-Aminobutyric Acid (GABA)ergic Neural Circuit in Salicylate-Induced Tinnitus: the Inferior Colliculus to the Medial Geniculate Body

Peng, X.-Y., Wang, J., Gong, M.-Y., Zhang, L.-Y., Zhang, M., Chen, Z.-B., Tang, Z., & Cheng, L. (2025) · Clinical and Experimental Otorhinolaryngology · doi:10.21053/ceo.2025-00027 · Cited by 2 · see citing works

[Research progress in auditory center plasticity and tinnitus mechanism].

Luo, Y., Feng, S., Jiang, X., Gong, S., & Liu, K. (2021) · PubMed Central · doi:10.13201/j.issn.2096-7993.2021.11.017 · Cited by 2 · see citing works

Predicting the optimal therapeutic intervention for tinnitus patients using random forest regression: A preliminary study of UNITI's decision support system model

Bromis, K., Sarafidis, M., Manta, O., Kouris, I., Vellidou, E., Schlee, W., & Koutsouris, D. (2022) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc48229.2022.9871331 · Cited by 2 · see citing works

Adaptation and Validation of the Turkish Version of the International Tinnitus Inventory

Kamışlı, G. İ. Ş., Çabuk, G. B., & Aksoy, S. (2023) · Turkish Archives of Otorhinolaryngology · doi:10.4274/tao.2023.2023-5-16 · Cited by 1 · see citing works

Effects of traditional Chinese medicine on symptoms of patients with spleen and stomach deficiency-related tinnitus

Cui, N., Zhao, C., Xue, J., & Zhu, X.-W. (2024) · World Journal of Clinical Cases · doi:10.12998/wjcc.v12.i28.6165

Comparison of GWAS results between de novo tinnitus and cancer treatment-related tinnitus suggests distinctive roles for genetic risk factors

Shahbazi, M., Wheeler, H. E., Armstrong, G. T., Frisina, R. D., Travis, L. B., & Dolan, M. E. (2024) · Scientific Reports · doi:10.1038/s41598-024-78274-w · Cited by 1 · see citing works

Altered Glymphatic Function in Tinnitus: Associations With Cognition and Effects of rTMS

Ye, W.-J., Du, Y., Li, S., Xu, Q.-H., Fang, Z.-H., Xu, J.-J., Zhang, H., Salvi, R., Chen, Y.-C., & Cai, Y.-X. (2026) · The Laryngoscope · doi:10.1002/lary.70384 · Cited by 1 · see citing works

Association between diabetes and tinnitus traits in the UK Biobank: a population-based cohort study

Ji, X., Zhang, Z. Y., Shao, X., Yu, R., Gu, D., Ren, J., & Zhao, H. (2026) · Acta Diabetologica · doi:10.1007/s00592-026-02695-4 · Cited by 1 · see citing works

Comparison of Different Therapeutic Effects of T‐MIST for Chronic Idiopathic Tinnitus

Chaoqun, L., Fang, Q., Chen, H., Wang, Z., & Yang, J. (2022) · BioMed Research International · doi:10.1155/2022/9236822 · Cited by 1 · see citing works

A knowledge graph based intelligent auxiliary diagnosis and treatment system for primary tinnitus using traditional Chinese medicine

Yin, Z., Wang, L., Zhang, H., Kuang, Z., Yu, H., Li, T., Zhu, Z., & Guo, Y. (2024) · Egyptian Informatics Journal · doi:10.1016/j.eij.2024.100525 · Cited by 1 · see citing works

Frailty links the heterogeneity of tinnitus disorder and response to interventions in older patients

Ruan, J., Zhang, M., Han, Z., Chen, J., Ruan, Q., & Bao, Z. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1617821 · Cited by 1 · see citing works

Study of the Effect of Abnormalities in the External Ear Inducing Hearing Problems

Melloui, J., Bakkoury, J., & Bouattane, O. (2020) · Advances in Science Technology and Engineering Systems Journal · doi:10.25046/aj050457

Pharmacological Treatments for Tinnitus—Reply

Piccirillo, J. F., Rodebaugh, T. L., & Lenze, E. J. (2020) · JAMA · doi:10.1001/jama.2020.11868

The efficacy of betahistine dihydrochloride in the treatment of primary tinnitus: a randomized clinical trial studyPreprint

Castilho, G. L., Dias, N. H., & Martins, R. H. G. (2022) · doi:10.22541/au.165784145.52111957/v1

Efficacy of hearing aid treatment on sound perception and residual hearing preservation in patients with tinnitus and coexisting hearing loss: study protocol for a randomized controlled trial

Li, P.-F., Tang, D.-M., Wu, Y.-Z., Yin, Y., & Sun, S. (2022) · Trials · doi:10.1186/s13063-022-07014-0

Tumor characteristics, brain functional activity, and connectivity of tinnitus in patients with vestibular schwannoma: a pilot study

Huang, J., Lin, J., You, N. Y., Li, X., Xiong, Y., Wang, X., Lu, H., Li, C., Li, R., Hu, J., et al. (2024) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-23-721

Visuell snø – forstyrrende, men ufarlig

Kerty, E., Dalbro, S. E. J., & Elsais, A. (2024) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.24.0258

Combination of Electroacupuncture and Medication for Patients With Tinnitus Associated With Idiopathic Sudden Sensorineural Hearing Loss: Protocol for a Prospective Randomized Controlled Trial

Wang, T., Qi, L., Hao, X., Zhang, M., Du, S., Chen, B., Liu, C., Chen, J., Zou, X., Liu, P., et al. (2025) · JMIR Research Protocols · doi:10.2196/69163

The Role of Nutritional Factors and Age in the Pathogenesis and Treatment of Tinnitus

Mędrek, E., Kawczyńska, N., & Zegarska, P. (2025) · Medical Science · doi:10.54905/disssi.v29i161.e113ms3602

Additional file 2 of Efficacy of hearing aid treatment on sound perception and residual hearing preservation in patients with tinnitus and coexisting hearing loss: study protocol for a randomized controlled trial

Li, P., Tang, D., Wu, Y., Yin, Y., & Sun, S. (2023) · Figshare · doi:10.6084/m9.figshare.22616980

Additional file 3 of Efficacy of hearing aid treatment on sound perception and residual hearing preservation in patients with tinnitus and coexisting hearing loss: study protocol for a randomized controlled trial

Li, P., Tang, D., Wu, Y., Yin, Y., & Sun, S. (2023) · Figshare · doi:10.6084/m9.figshare.22616983

Additional file 1 of Efficacy of hearing aid treatment on sound perception and residual hearing preservation in patients with tinnitus and coexisting hearing loss: study protocol for a randomized controlled trial

Li, P., Tang, D., Wu, Y., Yin, Y., & Sun, S. (2023) · Figshare · doi:10.6084/m9.figshare.22616977

Additional file 4 of Efficacy of hearing aid treatment on sound perception and residual hearing preservation in patients with tinnitus and coexisting hearing loss: study protocol for a randomized controlled trial

Li, P., Tang, D., Wu, Y., Yin, Y., & Sun, S. (2023) · Figshare · doi:10.6084/m9.figshare.22616986

Cell-type-specific reorganization of VGSCs in auditory cortex and therapeutic potential of Nav1.6 blockade for tinnitus

Zhao, M., Sun, S., Jing, S., Ma, Z., Zhang, Z., Ji, Y., Xia, C., & Zhou, Y. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111733

Individual‐Level Brain Network Predictors and Distinct Reorganization Mechanism in Sound Therapies for Tinnitus

Li, J., Tong, Z., Cai, W., Xu, Q., Huang, X., Xiong, B., Ye, W., Fang, C., Chen, X., Deng, C., et al. (2026) · Otolaryngology · doi:10.1002/ohn.70210

An Open Comparative Study on the Effectiveness of Customized and Non-Customized Sound Therapy for Tinnitus Patients

Xie, H., Liu, Y., Yang, S. Y., Ni, T., Ruan, J., Jiang, Y., Lin, Z., Zhou, L., He, S., & Han, Z. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15124431

Efficacy and Safety of Acupuncture for Idiopathic Tinnitus: A Randomized Controlled Clinical Trial

Huang, L., Man, J., Gu, Y., Zhao, X., Cheng, M., Ming, S.-R., Chen, B., Wang, Y.-N., & Hou, W.-G. (2026) · International journal of clinical practice · doi:10.1155/ijcp/5489240

Periodontal Procedure Intensity and Incident Tinnitus in Korean Adults: A Nationwide Cohort Study

Kim, Y., Son, M., Kim, S., & Cho, B.-J. (2026) · Medicina · doi:10.3390/medicina62081578

Cannabis and Tinnitus in People with and without HIV

Okafor, C. N., Ware, D., Edmonds, A., Sharma, A., Gustafson, D. R., Lahiri, C. D., Brown, T. T., Springer, G., Torre, P., Abraham, A. G., et al. (2026) · Open AIDS Journal · doi:10.2174/0118746136457303260813073100

Modeling psychological processes in tinnitus disorder: Comparison of quantitative methods

Rodebaugh, T. L., Lee, C., Gates, K. M., Frumkin, M. R., Shin, J., Dizdar, K., Kallogjeri, D., & Piccirillo, J. (2026) · Methodological Innovations · doi:10.1177/20597991261488303

Chronic Tinnitus

Kreuzer, P. M., Vielsmeier, V., & Langguth, B. (2013) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2013.0278 · Cited by 61 · see citing works

A behavioural treatment approach to tinnitus

Scott, B. (1989) · Cited by 2 · see citing works

Sinnvoller Zeitpunkt medizinischer Rehabilitation bei Tinnitus

Brüeggemann, P., Kastellis, G., Hesse, G., & Mazurek, B. (2024) · HNO · doi:10.1007/s00106-024-01473-4

Current and Emerging Therapies for Chronic Subjective Tinnitus

Park, K. W., Kullar, P., Malhotra, C., & Stanković, K. M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206555 · Cited by 29 · see citing works

[Current diagnostics and treatment options for tinnitus].

Smit, J. V., Janssen, M. L. F., & de Kleine, E. (2023) · PubMed