Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

Into the Eye of the Cytokine Storm

Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940 · see citing works

Is a “Cytokine Storm” Relevant to COVID-19?

Sinha, P., Matthay, M. A., & Calfee, C. S. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.3313 · Cited by 718 · see citing works

Multiplex bead array assays for detection of soluble cytokines: Comparisons of sensitivity and quantitative values among kits from multiple manufacturers

Khan, S. S., Smith, M. S., Reda, D., Suffredini, A. F., & McCoy, J. P. (2004) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20021 · Cited by 357 · see citing works

Cytometry

Özgen, Ü., Savaşan, S., Buck, S. A., & Ravindranath, Y. (2010) · Cytometry · doi:10.1002/(issn)1097-0320 · Cited by 211 · see citing works

Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients

Timmermans, K., Kox, M., Vaneker, M., van den Berg, M. P., John, A. T., van Laarhoven, A., van der Hoeven, H., Scheffer, G. J., & Pickkers, P. (2016) · Intensive Care Medicine · doi:10.1007/s00134-015-4205-3 · Cited by 184 · see citing works

Norepinephrine Contributes to Enterocyte Damage in Septic Shock Patients: A Prospective Cohort Study

Habes, Q. L. M., van Ede, L., Gerretsen, J., Kox, M., & Pickkers, P. (2017) · Shock · doi:10.1097/shk.0000000000000955 · Cited by 32 · see citing works

The Involvement of Danger-Associated Molecular Patterns in the Development of Immunoparalysis in Cardiac Arrest Patients

Timmermans, K., Kox, M., Gerretsen, J., Peters, E., Scheffer, G. J., van der Hoeven, J. G., Pickkers, P., & Hoedemaekers, C. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001204 · Cited by 30 · see citing works

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Karki, R., Sharma, B. R., Tuladhar, S., Williams, E. P., Zalduondo, L., Samir, P., Zheng, M., Sundaram, B., Banoth, B., Malireddi, R. K. S., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.025 · Cited by 1,734 · see citing works

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Bonaventura, A., Vecchié, A., Dagna, L., Martinod, K., Dixon, D. L., Tassell, B. W. V., Dentali, F., Montecucco, F., Maßberg, S., Levi, M. M., et al. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00536-9 · Cited by 1,010 · see citing works

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

Grant, R. A., Morales‐Nebreda, L., Markov, N. S., Swaminathan, S., Querrey, M., Rios-Guzman, E., Abbott, D. A., Donnelly, H. K., Donayre, A., Goldberg, I. A., et al. (2021) · Nature · doi:10.1038/s41586-020-03148-w · Cited by 703 · see citing works

COVID-19 and the human innate immune system

Schultze, J. L., & Aschenbrenner, A. C. (2021) · Cell · doi:10.1016/j.cell.2021.02.029 · Cited by 714 · see citing works

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

Osuchowski, M., Winkler, M., Skirecki, T., Cajander, S., Shankar-Hari, M., Lachmann, G., Monneret, G., Venet, F., Bauer, M., Brunkhorst, F., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00218-6 · Cited by 396 · see citing works

Pathophysiology of COVID-19-associated acute kidney injury

Legrand, M. M., Bell, S., Forni, L. G., Joannidis, M., Koyner, J. L., Liu, K. D., & Cantaluppi, V. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00452-0 · Cited by 508 · see citing works

Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial

Lenze, E. J., Mattar, C., Zorumski, C. F., Stevens, A., Schweiger, J., Nicol, G. E., Miller, J. P., Yang, L., Yingling, M., Avidan, M. S., et al. (2020) · JAMA · doi:10.1001/jama.2020.22760 · Cited by 495 · see citing works

Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial

Lanzoni, G., Linetsky, E., Correa, D., Messinger, S., Alvarez, R. A., Kouroupis, D., Gil, A. A., Poggioli, R., Ruiz, P., Marttos, A., et al. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.20-0472 · Cited by 404 · see citing works

Vitamin D and cardiovascular health

de la Guía-Galipienso, F., Martínez‐Ferrán, M., Vallecillo, N., Lavie, C. J., Sanchis‐Gomar, F., & Pareja-Galeano, H. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.025 · Cited by 348 · see citing works

The role of co-infections and secondary infections in patients with COVID-19

Feldman, C. H., & Anderson, R. (2021) · Pneumonia · doi:10.1186/s41479-021-00083-w · Cited by 317 · see citing works

SARS CoV‐2 related microvascular damage and symptoms during and after COVID‐19: Consequences of capillary transit‐time changes, tissue hypoxia and inflammation

Østergaard, L. (2021) · Physiological Reports · doi:10.14814/phy2.14726 · Cited by 319 · see citing works

Cytokine Storm—Definition, Causes, and Implications

Jarczak, D., & Nierhaus, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911740 · Cited by 317 · see citing works

Biomarkers in COVID-19: An Up-To-Date Review

Samprathi, M., & Jayashree, M. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2020.607647 · Cited by 297 · see citing works

Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity

Mercola, J. M., Grant, W. B., & Wagner, C. L. (2020) · Nutrients · doi:10.3390/nu12113361 · Cited by 268 · see citing works

Monocytes and Macrophages in COVID-19

Knoll, R., Schultze, J. L., & Schulte-Schrepping, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720109 · Cited by 269 · see citing works

Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

Lescure, F.-X., Honda, H., Fowler, R., Lazar, J. S., Shi, G., Wung, P. K., Patel, N. R., HAGINO, O. R., Bazzalo, I. J., Casas, M. M., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00099-0 · Cited by 247 · see citing works

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Thwaites, R. S., Uruchurtu, A. S. S., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., Fairfield, C. J., Carter, E., Abrams, S. T., Short, C.-E. S., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abg9873 · Cited by 227 · see citing works

The Pathophysiology of Sepsis-Associated AKI

Kuwabara, S., Goggins, E. S., & Okusa, M. D. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00850122 · Cited by 232 · see citing works

Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial

Supady, A., Weber, E., Rieder, M., Lother, A., Niklaus, T., Zahn, T., Frech, F., Müller, S., Kuhl, M., Benk, C., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00177-6 · Cited by 205 · see citing works

Essential Fatty Acids and Their Metabolites in the Pathobiology of Inflammation and Its Resolution

Das, U. N. (2021) · Biomolecules · doi:10.3390/biom11121873 · Cited by 183 · see citing works

Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis*

Karakike, E., Giamarellos‐Bourboulis, E. J., Kyprianou, M., Fleischmann-Struzek, C., Pletz, M. W., Netea, M. G., Reinhart, K., & Kyriazopoulou, E. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005195 · Cited by 182 · see citing works

The Role of Interleukin-8 in Lung Inflammation and Injury: Implications for the Management of COVID-19 and Hyperinflammatory Acute Respiratory Distress Syndrome

Cesta, M. C., Zippoli, M., Marsiglia, C., Gavioli, E. M., Mantelli, F., Allegretti, M., & BALK, R. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.808797 · Cited by 169 · see citing works

Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

Kyriazopoulou, E., Huet, T., Cavalli, G., Gori, A., Kyprianou, M., Pickkers, P., Eugen‐Olsen, J., Clerici, M., Veas, F., Châtellier, G., et al. (2021) · The Lancet Rheumatology · doi:10.1016/s2665-9913(21)00216-2 · Cited by 160 · see citing works

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Karagiannis, F., Peukert, K., Surace, L., Michla, M., Nikolka, F., Fox, M., Weiss, P., Feuerborn, C., Maier, P., Schulz, S., et al. (2022) · Nature · doi:10.1038/s41586-022-05128-8 · Cited by 146 · see citing works

COVID-19: Rethinking the Lockdown Groupthink

Joffe, A. R. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.625778 · Cited by 153 · see citing works

The role of IL-6 and IL-6 blockade in COVID-19

Potere, N., Batticciotto, A., Vecchié, A., Porreca, E., Cappelli, A., Abbate, A., Dentali, F., & Bonaventura, A. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1919086 · Cited by 124 · see citing works

SARS‐CoV‐2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage

Ma, J., Zhu, F., Shao, F., Shao, F., Yu, D., Ma, J., Zhang, X., Li, W., Qian, Y., Zhang, Y., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108249 · Cited by 113 · see citing works

COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

Rysz, S., Al-Saadi, J., Sjöström, A., Farm, M., Campoccia Jalde, F., Plattén, M., Eriksson, H., Klein, M., Vargas-Paris, R., Nyrén, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22713-z · Cited by 111 · see citing works

Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes

de Nooijer, A., Grondman, I., Janssen, N. A. F., Netea, M. G., Willems, L., van de Veerdonk, F. L., Giamarellos‐Bourboulis, E. J., Toonen, E. J. M., Joosten, L. A. B., RCI-COVID-19 study group, et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa646 · Cited by 114 · see citing works

Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic Suggestions

Root-Bernstein, R. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042108 · Cited by 110 · see citing works

Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody

Gebremeskel, S., Schanin, J., Coyle, K. M., Butuci, M., Luu, T. T., Brock, E. C., Xu, A., Wong, A., Leung, J., Korver, W., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.650331 · Cited by 111 · see citing works

Echocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study (the ECHO-COVID study)

Huang, S., Vignon, P., Dessap, A. M., Tran, S., Prat, G., Chew, M. S., Balík, M., Sanfilippo, F., Banauch, G., Clau-Terré, F., et al. (2022) · Intensive Care Medicine · doi:10.1007/s00134-022-06685-2 · Cited by 107 · see citing works

COVID-19 symptoms over time: comparing long-haulers to ME/CFS

Jason, L. A., Islam, M. F., Conroy, K. E., Cotler, J. H., Torres, C., Johnson, M., & Mabie, B. (2021) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2021.1922140 · Cited by 100 · see citing works

Letter to the Editor: Vitamin D deficiency in COVID-19: Mixing up cause and consequence

Smolders, J., van den Ouweland, J., Geven, C., Pickkers, P., & Kox, M. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154434 · Cited by 96 · see citing works

Endothelial Cells in Emerging Viral Infections

Fosse, J. H., Haraldsen, G., Falk, K., & Edelmann, R. J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.619690 · Cited by 94 · see citing works

The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness

Coopersmith, C. M., Antonelli, M. M., Bauer, S. R., Deutschman, C. S., Evans, L., Ferrer, R., Hellman, J., Jog, S., Kesecioğlu, J., Kissoon, N. “., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000004895 · Cited by 93 · see citing works

Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19

Jørgensen, M. J., Holter, J. C., Christensen, E. E., Schjalm, C., Tonby, K., Pischke, S. E., Jenum, S., Skeie, L. G., Nur, S., Lind, A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-78710-7 · Cited by 87 · see citing works

Excessive Matrix Metalloproteinase-1 and Hyperactivation of Endothelial Cells Occurred in COVID-19 Patients and Were Associated With the Severity of COVID-19

Syed, F., Li, W., Relich, R. F., Russell, P. M., Zhang, S., Zimmerman, M. K., & Yu, Q. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab167 · Cited by 88 · see citing works

Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients

Anderberg, S. B., Luther, T., Berglund, M., Larsson, R. L., Rubertsson, S., Lipcsey, M., Larsson, A. O., Frithiof, R., & Hultström, M. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155389 · Cited by 87 · see citing works

Autoimmunity to annexin A2 predicts mortality among hospitalised COVID-19 patients

Zuniga, M., Gomes, C., Carsons, S. E., Bender, M. T., Cotzia, P., Miao, Q., Lee, D. C., & Rodrı́guez, A. (2021) · European Respiratory Journal · doi:10.1183/13993003.00918-2021 · Cited by 86 · see citing works

Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity

Li, S., Ma, F., Yokota, T., Garcia, G., Palermo, A., Wang, Y., Farrell, C. P., Wang, Y.-C., Wu, R., Zhou, Z., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.145027 · Cited by 84 · see citing works

Distinctive features of severe SARS-CoV-2 pneumonia

Budinger, G. R. S., Misharin, A. V., Ridge, K. M., Singer, B. D., & Wunderink, R. G. (2021) · Journal of Clinical Investigation · doi:10.1172/jci149412 · Cited by 85 · see citing works

COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?

Ombrello, M. J., & Schulert, G. S. (2021) · Translational research · doi:10.1016/j.trsl.2021.03.002 · Cited by 83 · see citing works

Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients

DeKosky, S. T., Kochanek, P. M., Valadka, A. B., Clark, R. S. B., Chou, S., Au, A. K., Horvat, C. M., Jha, R. M., Mannix, R., Wisniewski, S. R., et al. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7332 · Cited by 83 · see citing works

Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis

Gorham, J., Moreau, A., Corazza, F., Peluso, L., Ponthieux, F., Talamonti, M., Izzi, A., Nagant, C., Djangang, N. N., Garufi, A., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244628 · Cited by 79 · see citing works

Serum ferritin at admission in hospitalized COVID-19 patients as a predictor of mortality

Lino, K., Guimarães, G. M. C., Alves, L. S., Oliveira, A. C., Faustino, R. D. S., Souza, C. F., Tupinambá, G., Medeiros, T., Silva, A. A., & Almeida, J. R. (2021) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2021.101569 · Cited by 79 · see citing works

Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial

Arnardottir, H. H., Pawelzik, S., Öhlund‐Wistbacka, U., Artiach, G., Hofmann, R., Reinholdsson, I., Braunschweig, F., Tornvall, P., Religa, D., & Bäck, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.624657 · Cited by 75 · see citing works

Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein

Yalçınkaya, M., Liu, W., Islam, M. N., Kotini, A. G., Gusarova, G. A., Fidler, T. P., Papapetrou, E. P., Bhattacharya, J., Wang, N., & Tall, A. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-04133-7 · Cited by 72 · see citing works

Attributable Mortality of Ventilator-associated Pneumonia Among Patients with COVID-19

Vacheron, C., Lepape, A., Savey, A., Machut, A., Timsit, J., Comparot, S., Courno, G., Vanhems, P., Landel, V., Lavigne, T., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202202-0357oc · Cited by 70 · see citing works

Lenzilumab in hospitalised patients with COVID-19 pneumonia (LIVE-AIR): a phase 3, randomised, placebo-controlled trial

Temesgen, Z., Burger, C. D., Baker, J., Polk, C. M., Libertin, C. R., Kelley, C. F., Marconi, V. C., Orenstein, R., Catterson, V. M., Aronstein, W. S., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00494-x · Cited by 68 · see citing works

Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19

Pongrácz, T., Nouta, J., Wang, W., van Meijgaarden, K. E., Linty, F., Vidarsson, G., Joosten, S. A., Ottenhoff, T. H. M., Hokke, C. H., de Vries, J. J. C., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103957 · Cited by 64 · see citing works

Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying miRNA as a Potential Multi Target Therapy to COVID-19: an In Silico Analysis

Schultz, I. C., Bertoni, A. P. S., & Wink, M. R. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10122-0 · Cited by 62 · see citing works

Identification of serum prognostic biomarkers of severe COVID-19 using a quantitative proteomic approach

Kimura, Y., Nakai, Y., Shin, J., Hara, M., Takeda, Y., Kubo, S., Jeremiah, S. S., Ino, Y., Akiyama, T. H., Moriyama, K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-98253-9 · Cited by 61 · see citing works

Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients

Youngs, J., Provine, N. M., Lim, N. T. Y., Sharpe, H., Amini, A., Chen, Y., Luo, J. F., Edmans, M. D., Zacharopoulou, P., Chen, W., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009804 · Cited by 57 · see citing works

The immunology of sepsis: translating new insights into clinical practice

Kox, M., Bauer, M. W., Bos, L. D. J., Bouma, H. R., Calandra, T., Calfee, C. S., Chousterman, B. G., Derde, L. P. G., Giamarellos‐Bourboulis, E. J., Gómez, H., et al. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-01004-6 · Cited by 68 · see citing works

Clinical phenotypes and outcomes of SARS-CoV-2, influenza, RSV and seven other respiratory viruses: a retrospective study using complete hospital data

Hedberg, P., Valik, J. K., van der Werff, S. D., Tanushi, H., Requena‐Méndez, A., Granath, F. N., Bell, M., Mårtensson, J., Dyrdak, R., Hertting, O., et al. (2021) · Thorax · doi:10.1136/thoraxjnl-2021-216949 · Cited by 56 · see citing works

Single-cell analysis of COVID-19, sepsis, and HIV infection reveals hyperinflammatory and immunosuppressive signatures in monocytes

Liu, N., Jiang, C., Cai, P., Shen, Z., Sun, W., Xu, H. Y., Fang, M., Yao, X., Zhu, L., Gao, X., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109793 · Cited by 53 · see citing works

COVID-19-Related ARDS: Key Mechanistic Features and Treatments

Selickman, J., Vrettou, C. S., Mentzelopoulos, S. D., & Marini, J. J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11164896 · Cited by 57 · see citing works

Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19

Matsuyama, T., Yoshinaga, S. K., Shibue, K., & Mak, T. W. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00892-y · Cited by 52 · see citing works

Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine - a review

Crapnell, R. D., Dempsey‐Hibbert, N., Sigley, E., Tridente, A., & Banks, C. E. (2022) · Microchimica Acta · doi:10.1007/s00604-022-05186-9 · Cited by 52 · see citing works

Precision Medicine for COVID-19

DeMerle, K. M., Angus, D., & Seymour, C. W. (2021) · JAMA · doi:10.1001/jama.2021.5248 · Cited by 49 · see citing works

Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury

Lassarén, P., Lindblad, C., Frostell, A., Carpenter, K. L. H., Guilfoyle, M. R., Hutchinson, P. J., Helmy, A. E., & Thelin, E. P. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02264-2 · Cited by 51 · see citing works

The anti-inflammatory cytokine response characterized by elevated interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro-inflammatory cytokine response in coronavirus disease 2019 (COVID-19)

Henry, B. M., Benoit, S. W., Vikse, J., Berger, B. A., Pulvino, C., Hoehn, J. M., Rose, J., de Oliveira, M. H. S., Lippi, G., & Benoit, J. L. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2020-1284 · Cited by 49 · see citing works

COVID-19 and immunothrombosis: Pathophysiology and therapeutic implications

Lim, M. S., & McRae, S. J. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103529 · Cited by 50 · see citing works

Differential Cytokine Signatures of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Influenza Infection Highlight Key Differences in Pathobiology

Karaba, A. H., Zhou, W., Hsieh, L. L., Figueroa, A., Massaccesi, G., Rothman, R. E., Fenstermacher, K. Z. J., Sauer, L. M., Shaw‐Saliba, K., Blair, P. W., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab376 · Cited by 49 · see citing works

MR-proADM as prognostic factor of outcome in COVID-19 patients

Sozio, E., Tascini, C., Fabris, M., D’Aurizio, F., Carlo, C. D., Graziano, E., Bassi, F., Sbrana, F., Ripoli, A., Pagotto, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-84478-1 · Cited by 49 · see citing works

Cytokine and Chemokine Levels in Coronavirus Disease 2019 Convalescent Plasma

Bonny, T. S., Patel, E. U., Zhu, X., Bloch, E. M., Grabowski, M. K., Abraham, A. G., Littlefield, K. E., Shrestha, R., Benner, S. E., Laeyendecker, O. B., et al. (2020) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaa574 · Cited by 49 · see citing works

Profile of Immunoglobulin G N-Glycome in COVID-19 Patients: A Case-Control Study

Hou, H., Yang, H., Liu, P., Huang, C., Wang, M., Li, Y., Zhu, M., Wang, J., Xu, Y., Wang, Y., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.748566 · Cited by 50 · see citing works

The role of extracellular histones in COVID‐19

de Vries, F., Huckriede, J., Wichapong, K., Reutelingsperger, C. P. M., & Nicolaes, G. A. F. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13585 · Cited by 47 · see citing works

Immunometabolic signatures predict risk of progression to sepsis in COVID-19

Oostdam, A. S. H.-V., Castañeda‐Delgado, J. E., Oropeza-Valdez, J. J., Borrego-Moreno, J. C., Monárrez‐Espino, J., Zheng, J., Mandal, R., Zhang, L., Soto-Guzmán, E., Fernández-Ruiz, J. C., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256784 · Cited by 46 · see citing works

A digital protein microarray for COVID-19 cytokine storm monitoring

Song, Y., Ye, Y., Su, S., Stephens, A., Cai, T., Chung, M. T., Han, M. K., Newstead, M. W., Yessayan, L., Frame, D. G., et al. (2020) · Lab on a Chip · doi:10.1039/d0lc00678e · Cited by 45 · see citing works

Status of mannose-binding lectin (MBL) and complement system in COVID-19 patients and therapeutic applications of antiviral plant MBLs

Gupta, A., & Gupta, G. S. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04107-3 · Cited by 45 · see citing works

Immunomodulation as Treatment for Severe Coronavirus Disease 2019: A Systematic Review of Current Modalities and Future Directions

Meyerowitz, E. A., Sen, P., Schoenfeld, S. R., Neilan, T. G., Frigault, M. J., Stone, J. H., Kim, A. Y., & Mansour, M. K. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1759 · Cited by 44 · see citing works

Cytokine profiles dynamics in COVID-19 patients: a longitudinal analysis of disease severity and outcomes

Ghaffarpour, S., Ghazanfari, T., Ardestani, S. K., Naghizadeh, M. M., Mahdavi, M. R. V., Salehi, M., Majd, A. M. M., Rashidi, A., Chenary, M. R., Mostafazadeh, A., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-98505-y · Cited by 44 · see citing works

Pulmonary Procoagulant and Innate Immune Responses in Critically Ill COVID-19 Patients

Nossent, E. J., Schuurman, A. R., Reijnders, T. D. Y., Saris, A., Jongerius, I., Blok, S. G., de Vries, H. J., Duitman, J., Noordegraaf, A. V., Meijboom, L. J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.664209 · Cited by 43 · see citing works

Review of the COVID-19 Risk in Multiple Sclerosis

Chaudhry, F., Jageka, C., Levy, P. D., Cerghet, M., & Lisak, R. P. (2021) · Journal of Cellular Immunology · doi:10.33696/immunology.3.080 · Cited by 42 · see citing works

Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier

Faist, A., Schloer, S., Mecate‐Zambrano, A., Janowski, J., Schreiber, A., Boergeling, Y., Conrad, B. C. G., Kumar, S., Toebben, L., Schughart, K., et al. (2022) · Antiviral Research · doi:10.1016/j.antiviral.2022.105475 · Cited by 42 · see citing works

Impact of early corticosteroids on 60-day mortality in critically ill patients with COVID-19: A multicenter cohort study of the OUTCOMEREA network

Dupuis, C., de Montmollin, É., Buetti, N., Goldgran-Tolédano, D., Reignier, J., Schwebel, C., Domitile, J., Neuville, M., Ursino, M., Siami, S., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255644 · Cited by 39 · see citing works

Comprehensive Immunologic Evaluation of Bronchoalveolar Lavage Samples from Human Patients with Moderate and Severe Seasonal Influenza and Severe COVID-19

Reynolds, D., Guillamet, C. V., Day, A., Borcherding, N. C., Guillamet, R. V., Choreño-Parra, J. A., House, S. L., O’Halloran, J. A., Zúñiga, J., Ellebedy, A. H., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100294 · Cited by 41 · see citing works

Covid-19: It's All About Sepsis

Vincent, J. (2021) · Future Microbiology · doi:10.2217/fmb-2020-0312 · Cited by 41 · see citing works

Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.Preprint

Karki, R., Sharma, B. R., Tuladhar, S., Williams, E. P., Zalduondo, L., Samir, P., Zheng, M., Sundaram, B., Banoth, B., Malireddi, R. K. S., et al. (2020) · PubMed · doi:10.1101/2020.10.29.361048 · Cited by 40 · see citing works

Vitamin D and Cardiovascular Diseases: An Update

Haider, F., Ghafoor, H., Hassan, O. F., Farooqui, K. J., Khair, A. O. M. B., & Shoaib, F. (2023) · Cureus · doi:10.7759/cureus.49734 · Cited by 39 · see citing works

Pathophysiology of the Acute Respiratory Distress Syndrome

Sinha, P., & Bos, L. D. J. (2021) · Critical Care Clinics · doi:10.1016/j.ccc.2021.05.005 · Cited by 41 · see citing works

IgG N-glycome changes during the course of severe COVID-19: An observational study

Petrović, T., Vijay, A., Vučković, F., Trbojević‐Akmačić, I., Ollivere, B. J., Marjanović, D., Bego, T., Prnjavorac, B., Đerek, L., Markotić, A., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104101 · Cited by 37 · see citing works

A comprehensive review on sarilumab in COVID-19

Khiali, S., Rezagholizadeh, A., & Entezari‐Maleki, T. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2021.1847269 · Cited by 38 · see citing works

Lung Protection vs. Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19

Lindner, H. A., Velásquez, S. Y., Thiel, M., & Kirschning, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.602130 · Cited by 38 · see citing works

Evolution of the nutritional status of COVID-19 critically-ill patients: A prospective observational study from ICU admission to three months after ICU discharge

Rives‐Lange, C., Zimmer, A., Merazka, A., Carette, C., Martins-Bexinga, A., Hauw‐Berlemont, C., Guérot, E., Jannot, A., Diehl, J., Czernichow, S., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.05.007 · Cited by 38 · see citing works

COVID-19 Coagulopathy: From Pathogenesis to Treatment

Alnima, T., Mulder, M. M. G., van Bussel, B. C. T., & Cate, H. T. (2022) · Acta Haematologica · doi:10.1159/000522498 · Cited by 37 · see citing works

Clinical efficacy and safety of interleukin-6 receptor antagonists (tocilizumab and sarilumab) in patients with COVID-19: a systematic review and meta-analysis

Yu, S., Koh, D.-H., Choi, M., Ryoo, S., Huh, K., Yeom, J., & Yoon, Y. K. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2059405 · Cited by 37 · see citing works

SARS-CoV-2: Immune Response Elicited by Infection and Development of Vaccines and Treatments

Canedo-Marroquín, G., Saavedra, F., Andrade, C. A., Berríos-Rojas, R. V., Rodríguez‐Guilarte, L., Opazo, M. C., Riedel, C. A., & Kalergis, A. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.569760 · Cited by 38 · see citing works

An Immune Epigenetic Insight to COVID-19 Infection

Jit, B. P., Qazi, S., Arya, R. K., Srivastava, A., Gupta, N., & Sharma, A. K. (2021) · Epigenomics · doi:10.2217/epi-2020-0349 · Cited by 37 · see citing works

COVID-19 Sepsis: Pathogenesis and Endothelial Molecular Mechanisms Based on “Two-Path Unifying Theory” of Hemostasis and Endotheliopathy-Associated Vascular Microthrombotic Disease, and Proposed Therapeutic Approach with Antimicrothrombotic Therapy

Chang, J. C. (2021) · Vascular Health and Risk Management · doi:10.2147/vhrm.s299357 · Cited by 37 · see citing works

Mechanistic Insights Into the Immune Pathophysiology of COVID-19; An In-Depth Review

Shafqat, A., Shafqat, S., Alsalameh, S., Kashir, J., AlKattan, K. M., & Yaqinuddin, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.835104 · Cited by 36 · see citing works

Lung compartmentalization of inflammatory biomarkers in COVID-19-related ARDS

Jouan, Y., Baranek, T., Si‐Tahar, M., Paget, C., & Guillon, A. (2021) · Critical Care · doi:10.1186/s13054-021-03513-9 · Cited by 36 · see citing works

Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection

Yatim, N., Boussier, J., Tétu, P., Smith, N., Bruel, T., Charbit, B., Barnabei, L., Corneau, A., Meda, L. D., Allayous, C., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg4081 · Cited by 35 · see citing works

Extracorporeal Blood Purification in Moderate and Severe COVID-19 Patients: A Prospective Cohort Study

Rosalia, R. A., Ugurov, P., Neziri, D., Despotovska, S., Kostoska, E., Veljanovska-Kiridjievska, L., Kuzmanov, D., Trifunovski, A., Villa, G., Popevski, D., et al. (2021) · Blood Purification · doi:10.1159/000515627 · Cited by 33 · see citing works

COVID-19: Lung-Centric Immunothrombosis

Kvietys, P. R., Fakhoury, H. M. A., Kadan, S., Yaqinuddin, A., Mutairy, E. A., & AlKattan, K. M. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.679878 · Cited by 33 · see citing works

Kidney Injury in COVID-19: Epidemiology, Molecular Mechanisms and Potential Therapeutic Targets

Teixeira, J. P., Barone, S., Zahedi, K. A., & Soleimani, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042242 · Cited by 33 · see citing works

LENZILUMAB EFFICACY AND SAFETY IN NEWLY HOSPITALIZED COVID-19 SUBJECTS: RESULTS FROM THE LIVE-AIR PHASE 3 RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIALPreprint

Temesgen, Z., Burger, C. D., Baker, J. V., Polk, C. M., Libertin, C. R., Kelley, C. F., Marconi, V. C., Orenstein, R., Durrant, C., Chappell, D. B., et al. (2021) · medRxiv · doi:10.1101/2021.05.01.21256470 · Cited by 32 · see citing works

Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study)

Lumlertgul, N., Hall, A., Camporota, L., Crichton, S. L., & Ostermann, M. (2021) · Critical Care · doi:10.1186/s13054-021-03476-x · Cited by 32 · see citing works

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

Leisman, D. E., Ronner, L., Pinotti, R., Taylor, M. D., Sinha, P., Calfee, C. S., Hirayama, A. V. V., Mastroianni, F., Turtle, C. J., Harhay, M. O., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30404-5 · Cited by 849 · see citing works

Selection of the Appropriate Control Group Is Essential in Evaluating the Cytokine Storm in COVID-19

Vassiliou, A. G., Dimopoulou, I., Jahaj, E., Keskinidou, C., Mastora, Z., Orfanos, S. E., & Kotanidou, Α. (2021) · In Vivo · doi:10.21873/invivo.12381 · Cited by 4 · see citing works

Covid-19 and Cytokine Storm

Vergara, L. L., Torralba, L., Diego, C. D., Lasierra, A., Lahoz, R., Abadía, C., de Gopegui, P. R., Godino, J., Cebollada, A., Jimeno, B., et al. (2022) · 10.01 - Respiratory infections and bronchiectasis · doi:10.1183/13993003.congress-2022.3255

COVID 19: in the eye of the cytokine storm

Liuzzo, G., & Patrono, C. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa1005 · Cited by 29 · see citing works

Drastically elevated levels of Interleukin-6 and its soluble receptor complex in COVID-19 patients with acute respiratory distress

Spigna, G. D., Cernia, D. S., Vargas, M., Buonavolontà, L., Servillo, G., & Postiglione, L. (2020) · Clinical and Medical Investigations · doi:10.15761/cmi.1000211 · Cited by 15 · see citing works