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Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions
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This study compares levels of tumor necrosis factor α, IL-6, and IL-8 in critically ill patients with coronavirus disease 2019 (COVID-19) vs those with other critical illness to better characterize the contribution of cytokine storm to COVID-19 pathophysiology.
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“observed elevated IL-6 levels are considerably lower than e.g., in septic shock or CRS due to other causes”
From COVID-19 and the human innate immune system (2021) · cites this paper as Kox et al., 2020
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Self-citationNorepinephrine Contributes to Enterocyte Damage in Septic Shock Patients: A Prospective Cohort Study
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Metadata
- Authors
- Kox, M., Waalders, N. J. B., Kooistra, E. J., Gerretsen, J., & Pickkers, P.
- Affiliations
- Radboud University Medical Center (NL)
- Corresponding author
- Pickkers, Peter
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2020-10-20
- Volume
- 324
- Issue
- 15
- Pages
- 1565
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC7489366
- OpenAlex
- W3082201689
- Cited by
- 333
- References
- 8
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 27 · 2023: 32 · 2022: 74 · 2021: 135 · 2020: 43
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- JAMA (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- COVID-19 pandemic, cytokine storm, TNF-α, interleukin-6, interleukin-8, critically ill patients, cytokine levels, SARS-CoV-2, critical illness
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