Age-Dependent Neutralization of SARS-CoV-2 and P.1 Variant by Vaccine Immune Serum Samples
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95% protection from COVID-19. 1 However, patient age is known to contribute to the risk of COVID-19 inc idence and severity.2 We examined the relationship between age and neutralizing antibody titers against the early SARS-CoV-2 USA-WA1/2020 strain and the P.1 variant of concern after 2 doses of the BNT162b2 vaccine.
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In both peak and 6-month periods, antibody levels were higher in women than men and declined with older age.
“We found that antibody levels in both periods were higher in women than in men and decreased with age, as has been previously shown for the first month after receipt of the second dose.7,16”
From Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months (2021) · cites this paper as [16]
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- Authors
- Bates, T. A., Leier, H. C., Lyski, Z. L., Goodman, J. R., Curlin, M. E., Messer, W. B., & Tafesse, F. G.
- Affiliations
- Oregon Health & Science University (US)
- Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland
- Corresponding author
- Tafesse, Fikadu G.
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2021-09-07
- Volume
- 326
- Issue
- 9
- Pages
- 868
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC8295896
- OpenAlex
- W3183923345
- Cited by
- 99
- References
- 7
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 11 · 2023: 22 · 2022: 45 · 2021: 10
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- M.J. Murdock Charitable Trust
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI145835)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Keywords
- SARS-CoV-2, P.1 variant, neutralizing antibodies, BNT162b2, age, vaccine response, COVID-19 pandemic, vaccine efficacy, antibody titers
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