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Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination
Open accessAbstract
Serum neutralizing antibodies rapidly appear after SARS-CoV-2 infection 1 and vaccination 2 and are maintained for several months.3,4 The emergence of SARS-CoV-2 variants has raised concerns about the breadth of neutralizingantibody responses.We compared the neutralizing-antibody response to 4 variants in infected and vaccinated individuals to determine how mutations within the spike protein are associated with virus neutralization.
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“By contrast, using the live-virus FRNT neutralization assay (Fig. 1B and Fig. 2B), titers to WA1 were higher than those to D614G, consistent with previous studies of that assay (19).”
From Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants (2021) · cites this paper as [19]
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An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Jackson, L. A., Anderson, E. J., Rouphael, N. G., Roberts, P. C., Makhene, M., Coler, R. N., McCullough, M. P., Chappell, J. D., Denison, M. R., Stevens, L. J., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2022483 · Cited by 3,237
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Self-citationNeutralizing Activity of BNT162b2-Elicited Serum
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Self-citationRapid Generation of Neutralizing Antibody Responses in COVID-19 Patients
Suthar, M. S., Zimmerman, M. G., Kauffman, R. C., Mantus, G., Linderman, S. L., Hudson, W. H., Vanderheiden, A., Nyhoff, L., Davis, C. W., Adekunle, O., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100040 · Cited by 508
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Metadata
- Authors
- Edara, V. V., Hudson, W. H., Xie, X., Ahmed, R., & Suthar, M. S.
- Affiliations
- Emory University (US)
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Suthar, Mehul S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2021-05-11
- Volume
- 325
- Issue
- 18
- Pages
- 1896
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC7980146
- OpenAlex
- W3136247297
- Cited by
- 150
- References
- 7
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 9 · 2023: 20 · 2022: 55 · 2021: 51
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Emory University
- Children's Healthcare of Atlanta
- National Institutes of Health (COVID-19, P51OD011132)
- National Institute on Aging (R00AG049092)
- National Institute of Allergy and Infectious Diseases (COVID-19, R24AI120942, K99AI153736, U19AI090023, R01AI148378, U01AI150747, R01AI127799, UM1AI148684, U19AI057266)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, neutralizing antibodies, SARS-CoV-2 variants, spike protein mutations, vaccine-induced immunity, natural infection, antibody breadth, virus neutralization
- MeSH terms
- Immunogenicity, Vaccine, COVID-19, SARS-CoV-2, COVID-19 Vaccines, COVID-19 Serological Testing, Antibodies, Viral, Humans, Antibodies, Neutralizing
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