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SARS-CoV-2–Specific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women
Open accessAbstract
This study found robust secretion of SARS-CoV-2 specific IgA and IgG antibodies in breast milk for 6 weeks after vaccination.IgA secretion was evident as early as 2 weeks after vaccination followed by a spike in IgG after 4 weeks (a week after the second vaccine).A few other studies have shown similar findings in women infected with COVID-19.5 Antibodies found in breast milk of these women showed strong neutralizing effects, suggesting a potential protective effect against infection in the infant.The study has limitations.First, no functional assays were performed.However, previous studies have showed neutralizing capacities of the same antibodies as measured for this study.Second, serum antibody testing or SARS-CoV-2 real-time reverse-transcriptase polymerase chain reaction testing were not performed, which would have provided interesting correlates.
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“Importantly, functional neutralizing antibodies against SARS-CoV-2 were found in infant cord blood and in the breast milk of vaccinated pregnant women”
From COVID-19 mRNA vaccines: Platforms and current developments (2022) · cites this paper as [118]
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“suggesting that there is a protective effect for newborns.116, 117, 118”
From COVID-19 mRNA vaccines: Platforms and current developments (2022) · cites this paper as [118]
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Metadata
- Authors
- Perl, S. H., Uzan-Yulzari, A., Klainer, H., Asiskovich, L., Youngster, M., Rinott, E., & Youngster, I.
- Affiliations
- Assaf Harofeh Medical Center (IL)
- Ben-Gurion University of the Negev (IL)
- Tel Aviv University (IL)
- Corresponding author
- Youngster, Ilan
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2021-05-18
- Volume
- 325
- Issue
- 19
- Pages
- 2013
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC8042567
- OpenAlex
- W3155604755
- Cited by
- 285
- References
- 3
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 19 · 2023: 57 · 2022: 102 · 2021: 85
- FWCI
- 20.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- SARS-CoV-2, COVID-19 vaccination, breastfeeding, breast milk, IgA, IgG, maternal antibodies, infant protection, neutralizing antibodies, vaccine response
- MeSH terms
- COVID-19, COVID-19 Vaccines, Adult, Antibodies, Viral, Breast Feeding, Female, Humans, Immunoglobulin A, Immunoglobulin G, Milk, Human, Prospective Studies
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