Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity
Open accessAbstract
The connection between triglyceride-rich lipoproteins and cardiometabolic multimorbidity, characterized by the concurrence of at least two of type 2 diabetes, ischemic heart disease, and stroke, has not been definitively established. We aim to examine the prospective associations between serum remnant cholesterol, triglycerides, and the risks of progression from first cardiometabolic disease to multimorbidity via multistate modeling in the UK Biobank. We also evaluate the causality of these associations via Mendelian randomization using 13 biologically relevant SNPs as the genetic instruments. Here we show that elevated remnant cholesterol and triglycerides are significantly associated with gradually higher risks of cardiometabolic multimorbidity, particularly the progression of ischemic heart disease to the multimorbidity of ischemic heart disease and type 2 diabetes. These results advocate for effective management of remnant cholesterol and triglycerides as a potential strategy in mitigating the risks of cardiometabolic multimorbidity.
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Mendelian randomization analyses confirm a causal relationship between lifelong TRL elevation and ASCVD.
“Observational cohorts demonstrate that higher TG and remnant cholesterol predict cardiovascular events independently of LDL-C, while Mendelian randomization analyses confirm a causal relationship between lifelong TRL elevation and ASCVD.”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [58]
The Results (Mendelian randomization analysis) report causal associations of genetically predicted remnant cholesterol and triglycerides with ischemic heart disease, supporting the claim for that cardiovascular outcome. The Discussion says MR estimates may indicate life-course effects, but the Results report no causal association with stroke; the paper therefore does not establish the broader claim about ASCVD as a whole. (LLM, conf=0.87)
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Lloyd-Jones, D. M., Hong, Y., Labarthe, D., Mozaffarian, D., Appel, L. J., Van Horn, L., Greenlund, K., Daniels, S., Nichol, G., Tomaselli, G. F., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192703 · Cited by 4,750 · see citing works
Fry, A., Littlejohns, T. J., Sudlow, C., Doherty, N., Adamska, L., Sprosen, T., Collins, R., & Allen, N. E. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx246 · Cited by 3,979 · see citing works
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
Bhatt, D. L., Steg, P. G., Miller, M., Brinton, E. A., Jacobson, T. A., Ketchum, S. B., Doyle, R. T., Juliano, R. A., Jiao, L., Granowitz, C., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812792 · Cited by 3,317 · see citing works
Association of cardiometabolic multimorbidity with mortality
Di Angelantonio, E., Kaptoge, S., Wormser, D., Willeit, P., Butterworth, A. S., Bansal, N., O’Keeffe, L. M., Gao, P., Wood, A. M., Burgess, S., et al. (2015) · JAMA · doi:10.1001/jama.2015.7008 · Cited by 1,155 · see citing works
Nordestgaard, B. G. (2016) · Circulation Research · doi:10.1161/circresaha.115.306249 · Cited by 1,116 · see citing works
Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease
Varbo, A., Benn, M., Tybjærg-Hansen, A., Jørgensen, A. B., Frikke-Schmidt, R., & Nordestgaard, B. G. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.08.1026 · Cited by 1,115 · see citing works
Elliott, P., Peakman, T. C., & Biobank, O. B. O. U. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dym276 · Cited by 996 · see citing works
Ginsberg, H. N., Packard, C. J., Chapman, M. J., Borén, J., Aguilar-Salinas, C. A., Averna, M., Ference, B. A., Gaudet, D., Hegele, R. A., Kersten, S., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab551 · Cited by 979 · see citing works
Loss-of-Function Mutations in <i>APOC3</i> and Risk of Ischemic Vascular Disease
Jørgensen, A. B., Frikke-Schmidt, R., Nordestgaard, B. G., & Tybjærg-Hansen, A. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1308027 · Cited by 919 · see citing works
Global epidemiology of dyslipidaemias
Pirillo, A., Casula, M., Olmastroni, E., Norata, G. D., & Catapano, A. L. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00541-4 · Cited by 882 · see citing works
Mendelian randomization of blood lipids for coronary heart disease
Holmes, M. V., Asselbergs, F. W., Palmer, T. M., Drenos, F., Lanktree, M. B., Nelson, C. P., Dale, C. E., Padmanabhan, S., Finan, C., Swerdlow, D. I., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/eht571 · Cited by 748 · see citing works
Self-citationFerence, B. A., Kastelein, J. J. P., Ray, K. K., Ginsberg, H. N., Chapman, M. J., Packard, C. J., Laufs, U., Oliver-Williams, C., Wood, A. M., Butterworth, A. S., et al. (2019) · JAMA · doi:10.1001/jama.2018.20045 · Cited by 724 · cited 1× · see citing works
“This needs to be mentioned in the Discussion section.”
Mika Kivimaki, B., Kuosma, E., Ferrie, J. E., Luukkonen, R. A., Nyberg, S. T., Alfredsson, L. S., Batty, G. D., Brunner, E. J., Fransson, E. I., Goldberg, M., et al. (2017) · The Lancet Public Health · doi:10.1016/s2468-2667(17)30074-9 · Cited by 695 · see citing works
Varbo, A., Benn, M., Tybjærg-Hansen, A., & Nordestgaard, B. G. (2013) · Circulation · doi:10.1161/circulationaha.113.003008 · Cited by 692 · see citing works
Genome-wide genetic data on ~500,000 UK Biobank participantsPreprint
Bycroft, C., Freeman, C., Petkova, D., Band, G., Elliott, L. T., Sharp, K., Motyer, A., Vukcevic, D., Delaneau, O., O’Connell, J., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/166298 · Cited by 606 · see citing works
Langsted, A., Freiberg, J. J., & Nordestgaard, B. G. (2008) · Circulation · doi:10.1161/circulationaha.108.804146 · Cited by 588 · see citing works
Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease
Castañer, O., Pintó, X., Subirana, I., Amor, A. J., Ros, E., Hernáez, Á., Martínez-González, M. Á., Corella, D., Salas-Salvadó, J., Estruch, R., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.008 · Cited by 540 · see citing works
Inactivating Variants in <i>ANGPTL4</i> and Risk of Coronary Artery Disease
Dewey, F. E., Gusarova, V., O’Dushlaine, C., Gottesman, O., Trejos, J., Hunt, C., Van Hout, C. V., Habegger, L., Buckler, D., Lai, K.-M. V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1510926 · Cited by 497 · see citing works
Lifestyle, cardiometabolic disease, and multimorbidity in a prospective Chinese study
Han, Y., Hu, Y., Yu, C., Guo, Y., Pei, P., Yang, L., Chen, Y., Du, H., Sun, D., Pang, Y., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab413 · Cited by 480 · see citing works
Self-citationHypertriglyceridaemia and risk of coronary artery disease
Reiner, Ž. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.31 · Cited by 386 · see citing works
Palmer, T., Sterne, J. A. C., Harbord, R. M., Lawlor, D. A., Sheehan, N. A., Meng, S., Granell, R., Smith, G. D., & Didelez, V. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr026 · Cited by 326 · see citing works
Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia
Borén, J., Taskinen, M.-R., Björnson, E., & Packard, C. J. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00676-y · Cited by 315 · see citing works
ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors
Gordts, P. L. S. M., Nock, R., Son, N.-H., Ramms, B., Lew, I., Gonzales, J. C., Thacker, B. E., Basu, D., Lee, R. G., Mullick, A. E., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86610 · Cited by 274 · cited 1× · see citing works
“This needs to be mentioned in the Discussion section.”
UK Biobank: Opportunities for cardiovascular research
Littlejohns, T. J., Sudlow, C., Allen, N. E., & Collins, R. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehx254 · Cited by 270 · see citing works
Remnants of the triglyceride-rich lipoproteins, diabetes, and cardiovascular disease
Chait, A., Ginsberg, H. N., Vaisar, T., Heinecke, J. W., Goldberg, I. J., & Bornfeldt, K. E. (2020) · Diabetes · doi:10.2337/dbi19-0007 · Cited by 229 · see citing works
Holmberg, M. J., & Andersen, L. W. (2022) · JAMA · doi:10.1001/jama.2022.1820 · Cited by 229 · see citing works
Wadström, B. N., Pedersen, K. M., Wulff, A. B., & Nordestgaard, B. G. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac822 · Cited by 209 · see citing works
Varbo, A., & Nordestgaard, B. G. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab293 · Cited by 174 · see citing works
The role of remnant cholesterol beyond low-density lipoprotein cholesterol in diabetes mellitus
Hu, X., Liu, Q., Guo, X., Wang, W., Yu, B., Liang, B., Zhou, Y., Dong, H., & Lin, J. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01554-0 · Cited by 158 · see citing works
Self-citationCrowther, M. J., & Lambert, P. C. (2017) · Statistics in Medicine · doi:10.1002/sim.7448 · Cited by 150 · see citing works
Remnant cholesterol and risk of ischemic stroke in 112,512 individuals from the general population
Varbo, A., & Nordestgaard, B. G. (2019) · Annals of Neurology · doi:10.1002/ana.25432 · Cited by 145 · see citing works
Wu, Y., Zhang, S., Qian, S. E., Cai, M., Li, H., Wang, C., Zou, H., Chen, L., Vaughn, M. G., McMillin, S. E., et al. (2022) · BMC Medicine · doi:10.1186/s12916-022-02573-0 · Cited by 132 · see citing works
Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm
Harrison, S. C., Holmes, M. V., Burgess, S., Asselbergs, F. W., Jones, G. T., Baas, A. F., Hof, F. N. G. V. ’., de Bakker, P. I. W., Blankensteijn, J. D., Powell, J. T., et al. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2017.4293 · Cited by 131 · see citing works
Ridker, P. M., Rifai, N., MacFadyen, J., Glynn, R. J., Jiao, L., Steg, P. G., Miller, M., Brinton, E. A., Jacobson, T. A., Tardif, J.-C., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.059410 · Cited by 131 · see citing works
Elevated Remnant Cholesterol Reclassifies Risk of Ischemic Heart Disease and Myocardial Infarction
Doi, T., Langsted, A., & Nordestgaard, B. G. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.03.384 · Cited by 129 · see citing works
Kaltoft, M., Langsted, A., & Nordestgaard, B. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa172 · Cited by 122 · see citing works
What is ‘remnant cholesterol’?
Stürzebecher, P. E., Katzmann, J. L., & Laufs, U. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac783 · Cited by 116 · see citing works
Triglyceride-Rich Lipoprotein Remnants and Cardiovascular Disease
Duran, E. K., & Pradhan, A. D. (2020) · Clinical Chemistry · doi:10.1093/clinchem/hvaa296 · Cited by 108 · see citing works
Huh, J. H., Han, K.-D., Cho, Y. K., Roh, E., Kang, J. G., Lee, S. J., & Ihm, S. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01667-6 · Cited by 106 · see citing works
Silva, N. M. G. D., Freathy, R. M., Palmer, T., Donnelly, L. A., Luan, J., Gaunt, T. R., Langenberg, C., Weedon, M. N., Shields, B. M., Knight, B. A., et al. (2011) · Diabetes · doi:10.2337/db10-1317 · Cited by 91 · see citing works
Zhao, Y., Li, Y., Zhuang, Z., Song, Z., Wang, W., Huang, N., Dong, X. Y., Xiao, W., Jia, J., Liu, Z., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05761-y · Cited by 81 · see citing works
Self-citationLotta, L. A., Stewart, I. D., Sharp, S. J., Day, F. R., Burgess, S., Luan, J., Bowker, N., Cai, L., Li, C., Wittemans, L. B. L., et al. (2018) · JAMA Cardiology · doi:10.1001/jamacardio.2018.2866 · Cited by 78 · see citing works
Risk of cardiovascular disease and loss in life expectancy in NAFLD
Shang, Y., Nasr, P., Widman, L., & Hagström, H. (2022) · Hepatology · doi:10.1002/hep.32519 · Cited by 69 · see citing works
Avoiding collider bias in Mendelian randomization when performing stratified analyses
Coscia, C., Gill, D., Benítez, R., Pérez, T., Malats, N., & Burgess, S. (2022) · European Journal of Epidemiology · doi:10.1007/s10654-022-00879-0 · Cited by 52 · see citing works
Oelrich, B., Dewell, A., & Gardner, C. D. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.06.003 · Cited by 41 · see citing works
Gordillo‐Marañón, M., Zwierzyna, M., Charoen, P., Drenos, F., Chopade, S., Shah, T., Engmann, J., Casas, J. P., Chaturvedi, N., Papacosta, O., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25731-z · Cited by 32 · see citing works
Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity
Innes, H. A., Crooks, C. J., Aspinall, E., Card, T. R., Hamill, V., Dillon, J. F., Guha, I. N., Hayes, P. C., Hutchinson, S. J., West, J., et al. (2021) · Hepatology · doi:10.1002/hep.32123 · Cited by 31 · see citing works
Szili‐Török, T., Sokooti, S., Osté, M. C. J., Neto, A. W. G., Dullaart, R. P. F., Bakker, S. J. L., & Tietge, U. J. F. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01475-y · Cited by 24 · see citing works
Triglyceride Metabolism Modifies Lipoprotein(a) Plasma Concentration
Ramos-Cáceres, M., Lamíquiz-Moneo, I., Cenarro, A., Calmarza, P., Marco-Benedí, V., Bea, A. M., Mateo‐Gállego, R., Puzo, J., Ordovás, J. M., Civeira, F., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac412 · Cited by 19 · see citing works
Lai, C., Parnell, L. D., Lee, Y., Zeng, H., Smith, C. E., McKeown, N. M., Arnett, D. K., & Ordovás, J. M. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1117778 · Cited by 15 · see citing works
Vergara, M., Hauser, M. E., Aronica, L., Rigdon, J., Fielding‐Singh, P., Shih, C. W., & Gardner, C. D. (2021) · Nutrients · doi:10.3390/nu13061935 · Cited by 4 · see citing works
Zhao, Y. (2024) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.10560861 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Lai, H., Tu, Y., Liao, C., Zhang, S., He, L., & Li, J. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02667-y · Cited by 61 · see citing works
Cummings, B. B., Joing, M. P., Bouchard, P. R., Milton, M. N., Moesta, P. F., Ramanan, V., Lane, A., Hirman, J., Trauger, J. W., Maratos-Flier, E., et al. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00825-6 · Cited by 49 · see citing works
Transport functions of intestinal lymphatic vessels
Tso, P., Bernier‐Latmani, J., Petrova, T. V., & Liu, M. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00996-z · Cited by 33 · see citing works
Drugs for dyslipidaemia: the legacy effect of the Scandinavian Simvastatin Survival Study (4S)
Strandberg, T. E., Kovanen, P. T., Lloyd‐Jones, D. M., Raal, F. J., Santos, R. D., & Watts, G. F. (2024) · The Lancet · doi:10.1016/s0140-6736(24)02089-0 · Cited by 29 · see citing works
[Incisional hernia after surgery for abdominal aortic aneurysm].
Augestad, K. M., Wilsgaard, T., & Solberg, S. K. (2002) · PubMed · Cited by 29 · see citing works
Interactions between lipid droplets and mitochondria in metabolic diseases
Wang, G., Sun, B., Liu, H., Hu, M., Xu, H., Li, H., Wang, X., & Tong, M. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02759-4 · Cited by 32 · see citing works
Sidorkiewicz, M. (2024) · Nutrients · doi:10.3390/nu16223937 · Cited by 28 · see citing works
Li, D., Lin, J., Yang, H.-X., Zhou, L.-H., Li, Y.-J., Xu, Z., Sun, L., Zhang, X.-Y., Xu, W.-L., & Wang, Y.-G. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02790-w · Cited by 28 · see citing works
Self-citationDietary medium-chain triacylglycerols in metabolic regulation
Cao, Y., Kanta, J. M., Bishop, C. A., Kiens, B., Fritzen, A. M., & Kleinert, M. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.09.010 · Cited by 25 · see citing works
Wulff, A. B., & Nordestgaard, B. G. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf274 · Cited by 22 · see citing works
Impact of Remnant Cholesterol on Cardiovascular Risk in Diabetes
Elías-López, D., Wadström, B. N., Vedel‐Krogh, S., Kobylecki, C. J., & Nordestgaard, B. G. (2024) · Current Diabetes Reports · doi:10.1007/s11892-024-01555-1 · Cited by 18 · see citing works
Aging and Sex Modify the Risk of Carotid Plaque Thrombosis Related to Dyslipidemic Profile
Servadei, F., Scimeca, M., Palumbo, V., Oddi, F. M., Bonfiglio, R., Giacobbi, E., Menghini, R., Casagrande, V., Cardellini, M., Martelli, E., et al. (2025) · Stroke · doi:10.1161/strokeaha.125.051754 · Cited by 18 · see citing works
Huang, M., Fu, R., Zhao, X., Liu, T., Li, X., & Jiang, W. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf247 · Cited by 15 · see citing works
Yu, G., Liu, L., Ma, Q., & He, H. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02356-x · Cited by 11 · see citing works
Wang, J., Zheng, Y., Jiang, Y., Suo, C., Zhang, T., Chen, X., & Xu, K. (2024) · Preventive Medicine · doi:10.1016/j.ypmed.2024.108211 · Cited by 11 · see citing works
Borén, J., Packard, C. J., Nordestgaard, B. G., & Catapano, A. L. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf214 · Cited by 12 · see citing works
Biomarkers of multimorbidity: A systematic review
Zazzara, M. B., Triolo, F., Biscetti, L., Paparazzo, E., Fiorillo, M., Vetrano, D. L., & Onder, G. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102870 · Cited by 12 · see citing works
He, Q., Yu, W., Rao, X., Lin, D., You, Y., Yan, L., Liang, W., Hua, F., Guan, X., & Wang, X. (2026) · Lipids in Health and Disease · doi:10.1186/s12944-026-02875-9 · Cited by 9 · see citing works
Ma, J., Xu, F., & Zhang, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-75951-8 · Cited by 8 · see citing works
Wang, H., Wang, J., Feng, D., Wang, L., & Zhang, J. (2025) · European journal of medical research · doi:10.1186/s40001-025-02693-2 · Cited by 8 · see citing works
Li, J., Fan, M., Yang, M., Huang, W., Shi, W., Zhang, D., Zhu, W., Liu, C., Xu, N., Zhang, H., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-25958-6 · Cited by 8 · see citing works
Liu, L., Meng, Y., Hu, L., Runa, A., Zhang, Y., & Gao, Z. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1725495 · Cited by 8 · see citing works
Wu, D., Shi, Y., Wang, C., Li, C., Lu, Y., Wang, C., Zhu, W., Sun, T., Han, J., Zheng, Y., et al. (2024) · Archives of Public Health · doi:10.1186/s13690-024-01361-x · Cited by 7 · see citing works
Wang, D., Zhang, Z., Zhang, Y., Chen, S., Qu, N., Li, H., Sun, Y., Tian, X., Han, X., Wu, S., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.038559 · Cited by 7 · see citing works
Zhang, W., Jing, C., Liu, X., & Hou, H. (2026) · Lipids in Health and Disease · doi:10.1186/s12944-025-02850-w · Cited by 7 · see citing works
Hou, X., Wang, G., & Gao, Y. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03191-3 · Cited by 7 · see citing works
Miyake, T., Furukawa, S., Matsuura, B., Yoshida, O., Kanamoto, A., Miyazaki, M., Shiomi, A., Nakaguchi, H., Okazaki, Y., Nakamura, Y., et al. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae597 · Cited by 7 · see citing works
Du, J., Man, Z., Bai, X., Luo, D., Guo, Q., Wang, Y., Yan, Y., Su, X., & Zheng, W. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03151-x · Cited by 6 · see citing works
Feng, X., Liu, Y., Yang, J., Zhou, Z., Yang, S., Zhou, Y., & Guo, Q. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02258-y · Cited by 6 · see citing works
Lin, C., Wen, H., Yu, M., Huang, Q., Wang, Q., Lin, J., Yang, W., Wong, J. M. J., Xia, M., Tang, H., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04329-y · Cited by 5 · see citing works
Muheiyati, G., Wang, J., Chen, X., Guan, X., An, H., & Tao, N. (2025) · Scientific Reports · doi:10.1038/s41598-025-01963-7 · Cited by 5 · see citing works
A cross-sectional analysis of remnant cholesterol-diabetes association in US adults
Li, X., Cui, G., & Xuemin, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-10961-8 · Cited by 5 · see citing works
Vasdev, N., Gupta, T., Bain, A., Mishra, M., Sahu, R., Pawar, B., & Tekade, R. K. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146217 · Cited by 5 · see citing works
Bai, W., Zhou, G., Jiang, H., Li, X., & Shao, J. (2025) · Human Genomics · doi:10.1186/s40246-025-00789-8 · Cited by 4 · see citing works
Xie, X., Li, X., Li, H., Gao, Y., Zhao, F., & Chen, J. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1642358 · Cited by 4 · see citing works
Roh, E., Heo, J. H., Jung, H. N., Han, K., Kang, J. G., Lee, S. J., & Ihm, S. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2024.0406 · Cited by 4 · see citing works
Guo, S., Wang, C., Hu, T., Lan, L., Ge, Z., Huang, J., Chen, S., Wu, S., & Xue, H. (2025) · Journal of Clinical Hypertension · doi:10.1111/jch.70084 · Cited by 4 · see citing works
Li, L., Wang, J., Li, J., Li, M., Wang, J., Long, T., Zhengliu, Y., Tan, X., Peng, Y., & Hong, X. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1522212 · Cited by 4 · see citing works
Li, K., Liu, S., Wang, J., Liu, Z., & Qi, C. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm25739 · Cited by 4 · see citing works
Li, X.-X., Zhang, J.-Y., Chen, S.-Y., Wu, X., Ma, C., & Shen, H. (2025) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-025-07871-y · Cited by 3 · see citing works
Wang, N., Shi, X., Wang, T., Jia, X., Fan, Z., Yang, C., Wang, Y., Fan, J., Zhao, C., Niu, Y., et al. (2025) · Maturitas · doi:10.1016/j.maturitas.2025.108689 · Cited by 3 · see citing works
Li, G., He, L., Bai, X., Chen, S., Dai, H., He, G., Yang, Y., Zhang, X., Cui, J., Li, X., et al. (2025) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2025.101689 · Cited by 3 · see citing works
Shen, C., Yang, R., Zhou, Y., Cheng, Y., Cheng, Y., Yao, Y., Lv, Y., Zeng, R., Zhao, Q., Jia, Y., et al. (2026) · Clinical Research in Cardiology · doi:10.1007/s00392-026-02845-2 · Cited by 3 · see citing works
Shen, F., Liu, H.-Y., Liu, Y., Yang, J., Zhang, L.-W., Li, Q.-M., Liu, L., Gong, T.-T., Wu, Q., & Gao, S. (2026) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2025.11.020 · Cited by 3 · see citing works
Liao, C., Liu, H. T., Xu, S., Ling, Z., Zhuo, Y., Huang, G., Lin, W., & Zhang, Z. (2026) · Nutrients · doi:10.3390/nu18060985 · Cited by 3 · see citing works
Hu, L., & Zhao, Z. (2026) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-05387-z · Cited by 3 · see citing works
Feng, X., Bi, D., Pan, Y., Liu, K., Lei, W., Tang, X., & Xia, J. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03235-8 · Cited by 3 · see citing works
Zhang, M., Chen, J., Xia, W. T., Yu, Z., Zhang, C., Wang, W., Shao, Y., & Wang, B. (2025) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-025-03147-6 · Cited by 3 · see citing works
Self-citationChero‐Sandoval, L., Higuera‐Gómez, A., Martínez‐Urbistondo, M., Castejón, R., Mellor‐Pita, S., Moreno‐Torres, V., de Luis, D. A., Cuevas‐Sierra, A., & Martínez, J. A. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14339 · Cited by 3 · see citing works
He, Q., Wen, Y., Long, C., Lin, D., Lu, F., Zhong, M., Lin, W., Huang, S., Hua, S., Hua, F., et al. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02724-1 · Cited by 3 · see citing works
Gao, Y., Lei, T., Dang, P., & Li, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1512662 · Cited by 2 · see citing works
Self-citationSampath-Kumar, R., Padilla, E., Wilkinson, M. J., Barba, D. T., Aramburo, N., Mahmud, E., Ben‐Yehuda, O., & Taub, P. R. (2025) · JACC Advances · doi:10.1016/j.jacadv.2025.102247 · Cited by 2 · see citing works
Fang, Y., Wu, D., Shi, Z., Shen, J., Liu, E., Wu, X., Hu, W., & Lv, L. (2025) · Journal of Health Population and Nutrition · doi:10.1186/s41043-025-01118-4 · Cited by 2 · see citing works
Huang, M., Fu, R., Zhao, X., Liu, T., Li, X., & Jiang, W. (2026) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2026.101433 · Cited by 2 · see citing works
Wang, L., Li, H., Wang, L., Hao, J., Zhang, Q., Zhou, Q., Wang, J., & Qi, C. (2026) · Archives of Medical Science · doi:10.5114/aoms/218809 · Cited by 2 · see citing works
Consensus Interdisciplinary Positions of the Metabolic Syndrome Supervisory Committee
Shlyakhto, E. V., Arutyunov, G. P., Babenko, A. Y., Boytsov, S. A., Вадимовна, В. С., Dedov, I. I., Drapkina, O. M., Олеговна, Е. С., Звартау, Н. Э., Ivashkin, V. T., et al. (2026) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2026-7130 · Cited by 3 · see citing works
Yue, J., Luo, L., Guo, M., & Xu, C. (2025) · Expert Systems with Applications · doi:10.1016/j.eswa.2025.128816 · Cited by 2 · see citing works
Симонова, Г. И., Щербакова, Л. В., Malyutina, S. K., Каширина, А. П., & Ragino, Y. I. (2024) · Ateroscleroz · doi:10.52727/2078-256x-2024-20-3-326-344 · Cited by 1 · see citing works
Effects of remnant cholesterol on adverse renal outcomes in lupus nephritis
Shi, X., Zhang, X., Lu, Y., Xiang, W., Wang, X., Yu, J., Ye, H., Wu, H., Tang, R., Xia, X., et al. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02503-y · Cited by 1 · see citing works
Esmaeili, S., Fahimfar, N., Esmaeili, B., Rezaei–Tavirani, M., Razi, F., & Bandarian, F. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01692-8 · Cited by 1 · see citing works
Hsieh, H., Tien, N., Lin, C., Wong, W.-H., Lee, W.-Y., Chen, C., Tsai, F., You, B., Fang, Y., & Lim, Y.-P. (2025) · European journal of medical research · doi:10.1186/s40001-025-03130-0 · Cited by 1 · see citing works
Liu, Z., Li, M., Chen, Y., Wang, C., Chen, J., Long, H., Liu, R., Chiou, J. A., & Chen, C. (2025) · Nutrients · doi:10.3390/nu18010112 · Cited by 1 · see citing works
Lu, Z., Dong, B.-Q., Chen, L., Wei, H., & Zhang, H. (2026) · Lipids in Health and Disease · doi:10.1186/s12944-026-02894-6 · Cited by 1 · see citing works
Li, Y., Ling, Y., Wu, H., Luo, S., Luo, J., Tang, X. W., Li, S., Zhuang, X., Wu, B., Xiong, Z., et al. (2026) · Journal of clinical lipidology · doi:10.1016/j.jacl.2026.02.020 · Cited by 1 · see citing works
Self-citationHan, G., Lei, C. L., Shi, Y., Gao, J., Liu, X., Peng, K., Cai, Y., Hoi, P. M., & Yichong, L. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101047 · Cited by 1 · see citing works
Cholesterol metabolism dysregulated by key HBV mutations revealed through multi-omics profiling
Chen, Y., Lin, P., Jin, J., Deng, M., & Wei, D. (2026) · iScience · doi:10.1016/j.isci.2026.115844 · Cited by 1 · see citing works
Lee, M. P., Baca, P., Rivas, F., Zhang, A., Alegre-Díaz, J., Berumen-Campos, J., Kuri-Morales, P., North, K. E., Rodriguez, C. J., Stürmer, T., et al. (2026) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2026.101716 · Cited by 1 · see citing works
Association of pyridoxal 5′-phosphate (PLP) with lipid profiles: a population-based cohort study
Zhang, R., Chen, Y., Yan, X.-Q., Zhang, Y., Zhou, H. K., & Feng, Q. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1545301 · Cited by 1 · see citing works
Liu, J., Xu, Z., Wen, Y., Guo, X., Chen, X., Liu, D., Li, L., & Liu, H. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673374444250901100551 · Cited by 1 · see citing works
Targeting triglycerides for cardiovascular risk reduction
Maiorca, C., Tramontano, D., Di Costanzo, A., & D’Erasmo, L. (2026) · Internal and Emergency Medicine · doi:10.1007/s11739-026-04383-1
Yang, H.-T., Yang, Y., Liu, J., Zhang, J., & Zhang, J. (2024) · Research Square · doi:10.21203/rs.3.rs-4856821/v1
Babiker, M. A., & Elsayir, H. A. (2024) · Nanotechnology Perceptions · doi:10.62441/nano-ntp.vi.3670
Wu, L., Su, Z., Chen, X., Hu, H., & Wan, Q. (2024) · Research Square · doi:10.21203/rs.3.rs-5638991/v1
Demystifying the nuances of the lipid patient: a guide for primary care providers
Myerson, M. L., Gillett, K., O’Hara, J., Potter, R., & SKOLNIK, N. (2025) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2025.101070
Liu, Y., Zhang, F., Zhang, P., & Chen, L. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1648807
Vaquero, M. P., Álvarez, M. D., Zapatera, B., Saiz, A., & Cofrades, S. (2025) · Food & Function · doi:10.1039/d5fo00973a
Wang, N., Zhang, J., Wang, Y., Zhang, X., Shi, Y., Zhang, L., Xing, Y., & Lv, Q. (2025) · medRxiv · doi:10.1101/2025.09.26.25336774
Huang, X., Guo, X., Gan, Y., Xu, A., Sun, K., Shen, H., Niu, Z., Zhang, Y., Guo, Y., Ma, Y., et al. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2569988
Jiang, M., Li, X., & Lu, Y. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106157
Du, S., & Liu, Z. (2025) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2025.108582
Beyond cardiovascular disease: remnant cholesterol as a novel risk factor for osteoarthritis
Xie, R., Chen, Z., Zhang, G., & Zhao, W. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1692833
Ren, X., Yang, M., Tian, J., Chang, X., Wang, G., & Liu, J. (2025) · International Journal of Cardiology Cardiovascular Risk and Prevention · doi:10.1016/j.ijcrp.2025.200548 · Cited by 1 · see citing works
Association between multimorbidity and young-onset dementia: a prospective study
Chen, D., Zhang, M., Wen, Y., Han, H., Qin, Y., Zhang, R., Cao, H., & Yu, H. (2025) · BMC Public Health · doi:10.1186/s12889-025-25633-5
Mu, Y., Lu, Y., & Fu, W. (2026) · Brazilian Journal of Otorhinolaryngology · doi:10.1016/j.bjorl.2025.101747
Association between remnant cholesterol and cardiac conduction block: A prospective cohort study
Li, X., Li, M., Cao, L., Shi, S., Zheng, N., Peng, S., Guan, B., Jiang, T., Liu, S., Tse, G., et al. (2026) · Heart Rhythm · doi:10.1016/j.hrthm.2026.01.019
Xie, Y., Li, H., Xu, Y., Lv, D., Chu, J., Ye, J., & Huang, K. (2026) · BMC Gastroenterology · doi:10.1186/s12876-026-04623-w
Wulff, A. B., Varbo, A., Nordestgaard, A. G., & Nordestgaard, B. G. (2026) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2026.2639678 · Cited by 2 · see citing works
Owusu, F. M., Nawa, N., Khin, Y. P., Nishimura, H., Doi, S. K., Isumi, A., & Fujiwara, T. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1745206
Qi, M., Wang, M., Li, Y., & Cai, X. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.117170
Self-citationLiu, S. M., Zhang, Y., Zhao, H., Liu, J., & Hou, C. (2026) · Microchimica Acta · doi:10.1007/s00604-026-08055-x
Masrouri, S., Ebrahimi, N., Molavizadeh, D., Esmaeili, F., Azizi, F., & Hadaegh, F. (2026) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2026.104805
Li, S., Tao, L., Wu, D., F, X., & Luo, X. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1835874
王, 一. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1652171
Li, Y., Chen, Z.-Y., Shang, L., Wang, Y.-H., Liu, X.-Y., Yang, Y.-H., & He, L. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1770876
Self-citationRong, L., Fan, H.-D., Fang, Q., Li, X., Tan, J., & Huang, J. (2026) · Medicine · doi:10.1097/md.0000000000049157
Jiang, Y., Qian, A., Chen, S. H., Wu, Q., Xu, H., Zheng, C., Zhang, F., Xing, W., & He, J. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1874711
Li, Y., Zou, Z., Yi, S., Yang, Y., Yuan, G., & Xu, J. (2026) · PLoS ONE · doi:10.1371/journal.pone.0350895
Self-citationWu, X.-F., S, C., Zhang, Y.-C., Liu, S., Yan, B., & Li, X. G. (2026) · BMC Cardiovascular Disorders · doi:10.1186/s12872-026-06008-z
Zhou, Q., Liu, M., Wang, L., Wang, P., Qin, Y., Zhao, M., Wanyan, T., Yu, J., Wan, Y., Zhang, Q. X., et al. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1864976
Tang, S., & Tao, Y. (2026) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2026.104862
- Authors
- Zhao, Y., Zhuang, Z., Li, Y., Xiao, W., Song, Z., Huang, N., Wang, W., Dong, X., Jia, J., Clarke, R., & Huang, T.
- Affiliations
- Peking University (CN)
- University of Oxford (GB)
- Ministry of Education of the People's Republic of China (CN)
- Corresponding author
- Huang, Tao
- ORCID
- Venue
- Nature Communications
- Published
- 2024-03-19
- Volume
- 15
- Issue
- 1
- Pages
- 2451-2451
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC10951224
- OpenAlex
- W4392954776
- Cited by
- 117
- References
- 53
- Citations by year
- 2026: 52 · 2025: 47 · 2024: 17
- FWCI
- 38.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82173499, 82204026)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Keywords
- remnant cholesterol, triglycerides, cardiometabolic multimorbidity, type 2 diabetes, ischemic heart disease, stroke, triglyceride-rich lipoproteins, disease progression, multi-state models, Mendelian randomization, genetic instruments, causal inference
- MeSH terms
- Multimorbidity, Cholesterol, Diabetes Mellitus, Type 2, Humans, Hypercholesterolemia, Risk Factors, Triglycerides, Myocardial Ischemia
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